DEDICATION

This project is solely dedicated to God Almighty for his goodness, mercy, protection and blessing. I also dedicated this project to my Parent, siblings, and my uncle Michael Oyebanjo Paul and his family for their love, support and encouragement before, during and after the completion of this programme.

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ACKNOWLEDGEMENT Im very grateful to the Almighty God for making this work a success in all ramifications. A special appreciation to the family of Mr. & Mrs. Paul Oyebanjo without whose love, care, and all-round support this training would have been a disaster. I'm indebted to your family, may the Lord reward your family abundantly. Im indeed grateful to my elder brother Mr. Adebowale Adebanjo for his fatherly & brotherly support in my life and a special thanks to his lovely wife Mrs. Adebanjo Esther. I would not do without thanking the management of MOPSON PHARMACEUTICALS for giving me the privilege to observe my industrial training in their establishment. It was great working with you. I was able to run a successful industrial training under the aegis of my industry-based supervisor, Mr. Abdullahi wasiu (Mopson Q.C. manager) and also the member of staffs, Mr. Kolawole, Mr.Nnamdi, Mrs Victoria and Alhaja. Im very happy you all have shared in your experience with me. I am very grateful to you all. The support & love I got from my fellow I.T students, the teams formed in order to achieved common tasks must also not go without mentioning some few name for memorial, Mariam, John, Williams, Rose, Nneoma, Aderonke, Norah,Prisca,Zainab and others. Im happy we partnered to great usefulness, thank you all, I have also gained a lot from you. The last of my thanks goes to the rest of the people that have contributed in one way or another, but whose names I cannot mention due to different reasons, your efforts is greatly appreciated.

ABSTRACT ~
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The pharmaceutical industry develops, produces and markets drugs or pharmaceuticals licensed for use as medications. Pharmaceutical companies are allowed to deal in generic and/or brand medications and medical devices. Products are formulated into various dosage forms e.g. syrup, tablets, capsules, suspensions etc. The dosage forms in which the medications would be administered determine the type of processing with the raw materials will undergo. In this report, the various processes that raw materials undergo to produce the desired finished goods are outlined and properly defined. However the operating conditions of the processes are determined by the specifications for an individual drug. This report is therefore only good as a general pointer rather than drug-specific process definition. This report also briefly describes the way water is treated before use for production, procedures that include filtration, deionization, chlorination and UV sterilization. There are various analyses used in the laboratory to determine the purity of water, chloride test, sulphate test and others.

LIST OF ACRONYMS.

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API BP DNA ECOWAS EDTA ITF MD MOPSON NAFDAC NUC PCN PMG-MAN Nigeria SIC SIWES SON USD UV QC QA

Active Pharmaceutical Ingredients British Pharmacopeia Deoxyribonucleic Acid Economic Community of West African States EthyleneDiamineTetracetic Acid Industrial Training Fund Managing Director Micheal Oyebanjo Paul &.Sons. National Agency for Food and Drug Administration and Control National Universities Commission Pharmacists Council of Nigeria Pharmaceutical Manufacturing Group of the Manufacturers Association of Standard Industrial Classification Student Industrial Work Experience Scheme Standards Organization of Nigeria United States Dollars Ultra Violet Quality Control Quality Assurance

TABLE OF CONTENTS
PAGES Front page

iv

Dedications . Acknowledgement .. Abstract... List of acronyms . Table of contents . CHAPTER ONE 1.0. Introduction
1.1. 1.2. 1.3. 1.4. 1.5.

i ii iii iv v

Aims and objectives of industrial training scheme Objectives of siwes Background knowledge on pharmaceutical industries .. An introduction to Mopson Pharmaceutical .. Brand products and their dosage forms .

1 2 2 3 3

CHAPTER TWO

2.0.

Departments and duties .

2.1.1. Administrative department 2.1.2. Accounting department . 2.1.3. Marketing department ... 2.1.4. Store ... 2.1.5. Maintenance department 2.1.6. Production department ... 2.1.6.1. 2.1.6.2. 2.1.6.3.

6 6 6 6 6 6 7 7 7 7

Tablet production section ... Liquid syrup section ... Dry syrup section

2.1.7. Quality Assurance department ....

7 8 8 9 10 10

2.1.7.1. Quality Control .. 2.1.7.2. The chemistry unit . 2.1.7.3. The Microbiology Unit .. 2.1.7.4. In process Unit . 2.2. Some laboratory equipment and their uses CHAPTER THREE
3.0.

PRODUCTION MATERIALS
3.1. Water . 3.1.1. Regeneration of water 3.1.2. Water treatment flow chart 3.1.3. Primary water Treatment plant .. 3.1.4. Secondary water Treatment plant .. 3.1.5. Water Analysis ... 3.2. 3.3.

15 15 15 16 17 17 17 19 20

Raw Materials Packaging materials

CHAPTER FOUR

4.0. 4.1. 4.2.

FINISHED PRODUCTS ANALYSIS .. Method of analysis Supermag antacid . Method of analysis of Micpol tablets ..

CHAPTER FIVE

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5.0. Product stability and environment control 5.1. Product stability testing . 5.1.1. Factors that affect the stability of a pharmaceutical drug ... 5.1.2. Stability testing . 5.1.3. Definition of Terms ... 5.2. Environmental control

5.2.1. General hygienic control and environmental inspection 5.2.2. 5.3. Frequency of inspection . Challenges encountered ...

5.4. Contributions CHAPTER SIX

6.0.

Conclusion .
6.1.

Recommendations ..

References ...

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