Curriculum Vitae

What you are is Gods gift to you, what you make yourself is your gift to God.

Personal
Name Fathers Name Husbands Name Date & Place of Birth Nationality Occupation Present Position Mailing Address Dr. Farzana Latif Ansari (TI) Mohammad Latif Qureshi (Late) Javed Siraj Ansari 20-02-1951, Rawalpindi. Pakistani University Teaching and Research Professor (TTS) Department of Chemistry, Quaid-i-Azam University (QAU) Islamabad, Pakistan. Phone Fax: E-mail: Permanent Address 051-90642109, 4833745 (R), 051-90642241 <fla_qau@yahoo.com> 03335122265 (M)

180-C, Sector 1, Khayaban-e-Sirsyed, Rawalpindi, Pakistan.

Academic Qualifications
Examination Ph.D. Period Sep. 1986 Board/University Eberhard-Karls University, Tubingen,Germany. Quaid-i-Azam University Islamabad University Punjab University Sargodha Board Sargodha Board Division/Grade Magna cum laude (very good) 1st 1st 2nd 1st 1st

M.Phil. M.Sc. B.Sc. F.Sc. SSC

May 1978 Jan. 1976 Dec. 1973 Sep. 1971 Sep. 1968

Titles of Theses
M.Phil. Studies on the Influence of Substituents on the Stability of Five-Membered Lactone Rings. Ph.D. Ein Topf Weg Zur Darstellung von Flour-, Amin-, Cyan, Nitrat und Sulfat Zuckern. (One Pot Route to the Synthesis of Fluoro-, Amino-, Cyano-, Nitrate and Sulfate Sugars).

German Language Examinations

1. 2. 3. 4. Grundstuffe I Grundstuffe II Mittelstuffe I Comprehensive Examination. April - May 1983 June - July 1983 Aug. - Sep. 1983 Nov. 1983 Gthe Institute, Mannheim, Germany. Gthe Institute, Mannheim, Germany. Gthe Institute, Mannheim, Germany. Eberhand Karls University, Tbingen, Germany

Languages
English, German, Arabic, Urdu

Distinctions
3rd position (M.Sc.) 2nd position (M.Phil.)

Honors and Awards

International IUPAC Prize (Poster Competition), 2004 Shield from SAARC for displaying Instructional Material for Secondary School Students (1996). DAAD Scholarship (Apr. 1983 - Dec. 1985). Scholarship from Ministry of Science and Arts, Germany (Jan. 1986 to Sep. 1986). DAAD-Fellowship (Jun - Aug. 1991). DAAD-Fellowship (Jan. 19 Apr. 1996). DAAD Fellowship (Aug.12-Sep.22, 2010) Woman of the Year, 1998, nomination by American Biographical Institute (ABI). 2000 Millennium Medal of Honor, nomination by ABI.

National Tamgha-i-Imtiaz, 2000 Salam Prize Chemistry, 1990 3rd. Prize, All Pakistan Software Competition, 1994 1st Prize, Poster Competition, 2010 Merit Scholarship from Matric -Ph.D. 2

Shield from Pakistan Science Foundation for displaying Educational Software in Science and Technology Fair-92. Shield from Pakistan Science Foundation for displaying Computer Aided Lessons on Pericyclic Reactions in Science and Technology Expo-93.

As External Examiner
All national universities (public and private)

As Subject Specialist in Selection Boards

DAAD Selection Committee Federal Public Service Commission Allama Iqbal Open University

Membership of Learned Bodies

IUPAC Fellow Member Chartered Chemist (MRACI C Chem), The Royal Australian Chemical Institute Inc. National Representative, IUPAC Chemical Nomenclature & Structure Representation Division Fellow, The Chemical Society of Pakistan , CSP Life Member, CSP Whole Time Member, Third World Organization for Women in Science (TWOWS) Honorary Member, Professional Womens Advisory Board of American Biographical Institute (ABI). Member, Tbingen University Alumni (TUA). Member, German Alumni Forum Pakistan (GAFP)

Teaching and Research Experience

Post-Graduate/Post-Doctoral June 77 - June 78 June 78 - Dec. 78 May 78 June 78 Sep. 79 - Jan. 83 July 80 - Jan. 82 April 83 - Dec. 85 Jan. 86 - Sep. 86 Sep. 85 - April 86 Dec. 86 Dec 88 Research Officer (BPS 17), Pakistan Science Foundation (PSF) funded Project, Department of Chemistry, Quaid-i-Azam University, Islamabad. Lecturer (BPS 17), Govt. College for Women, Rawalpindi (appointed by the Punjab Public Service Commission). Completed M.Phil. Ph.D. Scholar Teaching Research Associate (BPS 17), Department of Chemistry, Quaid-iAzam University, Islamabad. Research Fellow (Honorary) in University Research Project. DAAD-Fellow, West Germany. Ph.D. Scholar Scientific Assistant conducted Biochemistry practicals (M.B.B.S. students) at Physiologisch-chemisches Institut, Universitt Tbingen, W. Germany. Post-Doctoral Fellow, Quaid-i-Azam University, Islamabad, Pakistan. Jan, 89-Jan 90 Post-Doctoral Fellow, University Grants Commission, 3

Islamabad 04.02.1990 03.03.1994 27.11.1999 10.01.2004 May 2006 31.05.2008 Dec. 86 Dec. 88 Lecturer (BPS 17), Quaid-i-Azam University, Islamabad. Assistant Professor (BPS 18), Quaid-i-Azam University Associate Professor (BPS 19), Quaid-i-Azam University Professor (BPS-20), Quaid-i-Azam University Professor (BPS 21), Quaid-i-Azam University Professor (TTS), Quaid-i-Azam University Post-Doctoral Fellow, Quaid-i-Azam University, Islamabad, Pakistan. Jan, 89-Jan 90 Post-Doctoral Fellow, University Grants Commission, Islamabad June Aug. 91 Jan. April 1996 Post-Doc Fellow (DAAD), University of Tbingen, Germany. Post-Doc Fellow (DAAD), University of Tbingen, Germany.

Aug. Sep, 2010

Post-Doc Fellow (DAAD), FMP, Berlin, Germany.

Research Guidance
Report/Thesis M.Sc. M.Phil. Ph.D. Completed 34 26 2+1 In Progress 3 5

Postgraduate Teaching
M.Sc. M.Phil. / Ph.D. Medicinal Chemistry Pericyclic Reactions Physical Organic Chemistry including Theoretical and Computational Chemistry & CADD. Introduction to organic chemistry as a fascinating science Reaction Mechanism Chemistry of Heterocycles Biochemistry Lab. courses involving analytical techniques Multistep organic synthesis of pharmaceutically important compounds

Undergraduate Teaching
The following lectures were delivered at different schools and colleges for introducing chemistry as an interesting and fascinating science: 4

Questions Children Often Ask Frontiers of Chemistry Low Cost Activity in Chemistry Hands-on-Chemistry OHP Laboratory Chemistry for Kids The Quran and Chemistry

Experience in Software Development

A software comprising a number of Computer Aided Lessons (CALS) on Pericyclic Reactions has been developed. These lessons are a supplement to the book Electrocyclic Reactions from Fundamentals to Research, which is published by Wiley-VCH. The developed CALS are being used in the department as teaching aid which has greatly facilitated the comprehension of the seemingly cumbersome subject of pericyclic reactions.

Computer Assisted Drug Designing (CADD)

Work has also been carried out in the direction of Computer Assisted Drug Designing (CADD) and a CADD lab has been established. A number of software namely Molecular Operating Environment (MOE) VMD, Accelrys etc. are being used for carrying out in silico design and synthesis of small drug like molecules of potential pharmacological interest.

Medicinal Chemistry
Various facets of medicinal chemistry are being explored both in wet and dry labs by synthesizing pharmacologically active compounds (solution and solid phase). Positional scanning protocol is used for the identification of leads in different combinatorial libraries of small drug like molecules. These concepts are also used in class room teaching by offering a course on medicinal to M.Phil/Ph.D. students.

Dissemination of Chemical Knowledge

National Level Extensive efforts have been made to popularize chemistry by delivering lectures at different schools and colleges on topics ranging from introducing chemistry as a fascinating science, building molecular models for facilitating comprehension of difficult concepts, low cost activity and demonstration of difficult concepts on Overhead Projector (OHP). The OHP demonstrations in the classroom, quite common in the western world, have not yet been practiced in Pakistan. These activities have helped in developing scientific attitudes and logical thinking in students both at undergraduate and postgraduate level. Efforts have been made to exploit Computer Assisted teaching by developing computer aided lessons and their display in different workshops, science exhibitions and in different universities of Pakistan and by writing chemistry books and reports on state of science education in Pakistan. International level As part of a six-member delegation of scientists, visited different German universities and research institutions with a view to strengthen the existing, and establishing new linkages, in the field of Medicinal Chemistry, Bioinformatics and Molecular Biology. The visit was jointly sponsored by the Higher Education Commission (HEC) and the Deutscher Forschungs Gemeinschaft (DFG). As a result thereof, MoUs were signed with University of Hamburg, University of Gttingen and Free University, Berlin to promote mutual collaboration with the scientists at both ends. In continuation to these efforts, the visit of a German professor-a reputed Medicinal Chemist ( Prof. Rademann from Berlin) was organized under FFHP of HEC and a workshop in combinatorial chemistry was organized. This workshop paved the way to the establishment of medicinal chemistry at QAU. Further, the visit of a well-known organic chemist (Prof. Langer from University of Rostock) was organized and preliminary work was carried out for 5

establishing a Center for Synthetic and Medicinal Chemistry at QAU with support from DAAD and HEC. In this connection a mega proposal has already been submitted to DAAD. The proposal is still in its infancy.

Organization of Conferences/Seminars/Workshops
2nd DAAD Follow-up Seminar held in Islamabad (Mar.11-13, 1991), Organizing Secretary. 3rd DAAD Follow-up Seminar held in Islamabad (Sep. 29-Oct.2, 1991), Member, Organizing Committee. 4th DAAD Follow-up Seminar, held in Islamabad (April 28-May 1, 1999), Organizing Secretary. 10th National Chemistry Conference, held in Islamabad (Oct. 28 23, 1999), Member, Organizing Committee. National Seminar on Frontiers of Chemistry held at Islamabad (Dec. 12, 2002), Organizing Secretary. Annual Day Celebration in the years 2007, 2008, 2009, Organizing Secretary. 1st Chemistry Alumni Meeting & One Day Seminar on Frontiers of Chemistry (May 15-16, 2009), Organizing Secretary. Workshop on Combinatorial Chemistry held in Islamabad (May 07-13, 2004) Coordinator. 5th International & 15th National Chemistry Conference held in Islamabad (Nov, 2004), Organizing Secretary. 8th International and 20th National Chemistry Conference (February 15-17, 2010), Organizing Secretary. DAAD Alumni Seminar, Islamabad, Oct. 29 31, 2010, Member, Organizing Committee.

Collaboration
Prof.Dr.K.Koehler Abteilung Anorganische Chemie Technische Universitt Mnchen Lichtenbergstrae 4 85747 Garching, Germany Prof. Dr. J. Rademann, Universitt Leipzig, Medicinal Chemistry, Institute of Pharmacy Brderstr. 34, 04103 Leipzig, Germany Prof. Dr. P. Langer Institt fr Chemie, Universitt Rostock Albert-Einstein Strae 9a , 18059 Rostock, Germany

Co-curricular activities
Convener, Seminar Committee Member , Ph.D. Admission Committee Member, Maintenance Committee Member, University Discipline Committee Member, Academic Council Member, Board of Faculty Chairperson, Girls Hostel Discipline Committee

Extra-curricular activities:
Compilation of the following books Science magazine Illustrative Thesaurus Echoes of a mother A star is born 6

Kids chemistry Yeh Batee kis ki Baytee hay (Whose daughter is she)?

References
Prof. Dr. Dr. W. Vlter, Leiter der Abteilung fr Physikalische Biochemie Physiologisch-chemisches Institut der Universitt Tbingen, Hoppe-Seyler Str. 4 Germany Tubingen 72706. Prof. Dr. J. Rademann, Universitt Leipzig, Medicinal Chemistry, Institute of Pharmacy, Brderstr. 34, 04103 Leipzig, Germany

Ph.D. Theses Supervised

Name Title Palladium leaching dependent on reaction parameters in SuzukiMiyaura coupling reactions catalyzed by Palladium supported on alumina Design, synthesis, bio-evaluation and computational studies on small drug-like molecules. Dihydropyrimidines as potential drug candidates-Design, synthesis, bioevaluation and computational studies. Solution and solid phase synthesis of some chalcones and the derived heterocycles of pharmacological significance. Year 2009

Saeeda Shahid Soomro (as CoSupervisor) Samina Nazir Umer Rashid

2010

Thesis under evaluation

Maj.Baseer Khan

(public defense already done)

M.Phil. Theses Supervised (1-21 as Supervisor, 22-24 as Co-Supervisor)

S.No. 1. 1. 2. 2. 3. 3. Sajid H. Awan Different methods for the coupling sugars with heterocyclic bases. Synthesis of some sugar substrates and their coupling with heterocycles. Synthesis and characterization of chiral sugar substrates. 1994 Nasir A. Kazmi Synthesis of nucleoside analogs. 1994 Name Ijaz-ur-Rehman Title A triflate mediated coupling of sugars with aza-heterocycles. Year 1992

4.
4.

Muhammad Naeem

2000

5.
5.

Naveeda Shaheen

2000

6. 6.

Sumera Umbreen

Synthesis and reactions of pharmaceutically important heterocycles. Synthesis and reactions of carbohydrates and benzothiazepine derivatives as potential surfactants. Synthesis and characterization of glycosylamides as potential surfactants. Combinatorial synthesis and pharmacological screening of 7membered benzothiazepines. Synthesis and characterization of small drug-like heterocycles Synthesis of some sugar substrates and their reactions with azaheterocycles, anilines and phenols. Combinatorial solution phase synthesis of molecular libraries of chalcones as potential antibacterial and cytotoxic agents. Synthesis and biological screening of combinatorial libraries of small drug like molecules .to establish structure activity relationship. Combinatorial synthesis and biological screening of small druglike molecules. Solution and solid phase synthesis of small drug like molecules. Design and synthesis of some novel semicarbazones as potential anticancer and anticonvulsant agents. Design, synthesis and theoretical & computational studies on heteroazepinone semicarbazones as potential anticonvulsants and antioxidants. Synthesis, bioevaluation and computational studies on 3,4dihydropyrimidines Design and synthesis of triazoles based on 1,3-dipolar cycloadditions

2000

7.
7. 8. 8

Shazia Saghir

2001

Shahid Ameen

2003

9.
9.

Latif Hussain Saima Nasir Sajida Sultana Samina Nazir Ihsan ullah

2003 2004 2005 2005 2006

10.
10.

11.
11.

12.
12.

13.
13.

14.
14.

Rasheed Ahmed Khera Fatima Iftikhar Sana Qureshi Saima Kalsoom

2006 2007 2007 2008

15.
15.

16.
16.

17.
17.

18.
18.

Iram Batool Sobia Shaheen

2008 2009

19.
19.

20.
20. 21. 22.

S. Aaliya Shehzadi

Triazoles at a click-synthesis, bio-evaluation and computational studies.

2009

Zahra Ali

Click synthesis and characterization of pharmaceutically significant mono-& bis-triazoles. Synthesis and characterization of biologically significant nucleosides and their derivatives (in collaboration). Preparations and reactions of some medicinally important azaheterocycles (in collaboration). Biological activities of chalcones and their libraries (in collaboration).

2010

Shahida Shujat

1995

23.

Humaira Y. Gondal Humaira Noureen

1999 2006

24.

Research Projects
No. Title Funding Agency URF Duration Designation

1.
1.

Synthesis of Benzimidazole-glycosides.

Dec. 86 to Dec. 87

Principal Investigator

2.
2. 3.

A Triflate-mediated Approach to Synthesis of Nucleoside Analogs.

URF

Dec. 87 - Dec. 88

Principal Investigator

4.
3.

On the Writing of a Book entitled Pericyclic Reactions-Fundamentals to Research (Part-I). On the writing of a Book entitled Pericyclic Reactions-Fundementals to Research (Part-II). Fluorocarbohydrates in the Synthesis of Anti-AIDS Nucleosides. Phase Transfer Catalysis of Glycosides.

URF

Jan. 92 - Dec. 92

Principal Investigator

5.
4.

URF

Apr. 93- Dec. 93

Principal Investigator

6.
5.

URF URF URF URF URF DAAD Germany

(4060.11 DM)

Feb. 94 - Jan. 95 1995 1996 1997-98 1998-99 1998-2002

Principal Investigator Principal Investigator Principal Investigator Principal Investigator Principal Investigator Principal Investigator

7.
6. 8. 7

Epoxysugars as substrates for the synthesis of Nucleosides Synthesis of Carbohydrate Building Blocks and Bioactive Natural Products. Epoxy sugars as Chiral Building Blocks. Synthesis of Carbohydrate Building Blocks. Synthesis and Reactions of Carbohydrate Building Blocks. Synthesis of Carbohydrate derived Surfactants and Studies on their Liquid Crystal Properties. Enantioselective Synthesis of Carbohydrate Building Blocks and Bioactive Natural Products. Synthesis and biological screening of combinatorial libraries of small druglike molecules to establish structure activity relation and drug development. Synthesis and bioevaluation of some novel anthraquinone sulfonamides

9.
9.

10.
90.

11.
10.

12.
11.

URF URF

2000-01 2001

Principal Investigator Principal Investigator

13.
12.

14.
13

PSF
(Rs.1,900,000)

2001 -6

Principal Investigator

15.
14.

HEC
(Rs.1,693,000)

2004 -6

Principal Investigator

16.

URF

2010

Principal Investigator

17.
15.

Computer Assisted Drug Designing

HEC
(Rs. 868,185)

2007

Principal Investigator

18.
16.

Computer aided design and synthesis of IL2 inhibitors as immunomodulating

HEC
(Rs.3,558,295)

2010 -2012

Principal Investigator

agents.

19.
17.

Computer aided identification and synthesis of -glucosidase inhibitors.

PSF
(Rs.1,978,882)

2010 -2012

Principal Investigator

Scientific Meetings
Conferences/Seminars (with presentations) 1. 19th. All Pakistan Science Conference held in Islamabad (Sep. 1-6, 1979). Title of paper presented: Synthesis of Benzimidazoles as Potential Therapeutic 2. 3. 4. Agents-I

20th. All Pakistan Science Conference held in Karachi (Aug. 21-27, 1981). Title of paper presented: Synthesis of Benzimidazoles as Potential Therapeutic Agents-II. 21st. All Pakistan Science Conference held in Bahawalpur (Dec. 31, 1982-Jan. 4, 1983). Title of paper presented: Studies on the Influence of Substituents on the Mechanism of Hydrolysis of -Lactones. 3rd. International Symposium and Pakistan-US Bi-national Workshop on Natural Products Chemistry held in Karachi (Jan. 9-14, 1988). Titles of papers presented: Some Recent Synthetic, Isolation and Structural Studies in Natural Products. Synthesis of 3,4-Dideoxy-3,4-cynomethylene pyranosides.

5.

4th. International Symposium on Natural Products Chemistry held in Karachi (Jan. 26-Feb. 3, 1990). Titles of papers presented. Synthesis of some Sugar Derivatives of potential Biochemical Interest. Synthesis and Spectroscopic Studies on some Aza-Heterocycles.

6. 7. 8. 9.

2nd. DAAD Follow-up Seminar held in Islamabad (Mar. 11-13, 1990). Title of paper presented: One pot Route to the Synthesis of Sugar Derivatives through Nucleophilic Substitution Reactions. 2nd. National Chemistry Conference held in Karachi (Dec. 28-31, 1990). Title of paper presented: Synthesis and Spectral Studies of some Sugar Sulphates. 4th. International Conference on CD held in Germany. Title of paper presented: Circular Dichorism of Carbohyrate-Metal Complexes. 5th. National Chemistry Conference (Oct. 27-29, 1993) held in Islamabad. Title of papers presented: A Triflate mediated Coupling of Sugars with Aza-Heterocycles. Computer Aided Lessons on Pericyclic Reactions.

10.

19th. IUPAC Symposium on the Chemistry of Natural Products organized by HEJ Research Institute of Chemistry, Karachi (Jan. 16-20, 1994). Title of Poster/Software displayed: Computer Aided Lessons on Pericyclic Reactions. Spectroscopy for Material Analysis, 2nd. National Symposium on Modern Trends in Contemporary Chemistry, Islamabad (April 4-6, 1995). Title of presentation Synthesis and NMR Spectral Studies of some Nucleosides and their Analogs. 8th. National Chemistry Conference held in Lahore (Sep. 2-4, 1997). Title of paper presented: Regio-, and Stereoselective Ring Opening of some Epoxypranosides through Titanium Isopropoxide and Sm I 2- A facile Route to Iododeoxy Sugars. 9th National Chemistry Conference held in Karachi (Dec. 6-8, 1998). Title of paper presented A Convenient Regioselective Synthesis of 3-Deoxy-3-Chloro and 3-Deoxy-3-allylhexapyranosides. 4th DAAD Follow-up Seminar, held in Islamabad (April 28-May 1, 1999). Title of paper presented Synthesis of 3-C-Alkyl Derivatives of some Hexopyranosides. 1st International and 11th National Chemistry Conference held in Peshawar (April 10-14, 2001). 10

11.

12.

13. 14. 15.

 16. 17.
nd

Synthesis of Aryl C-glycosides. Hands on Chemistry OHP Laboratory.

2 International & 12th National Chemistry Conference held in Jamshoro (Feb.4-6, 2002). Title of paper presented: Synthesis, Separation and Conformational Analysis of Diastereomeric Benzothiazepines. 7th Eurasia Conference on Chemical Sciences held at HEJ, Karachi (Mar.9-12, 2002). Title of paper presented: Pharmaceutically important Benzothiazepines, Synthesis, Separation and XRD analysis of Diastereomeric 1,5-Benzothiazepines. National Seminar on Frontiers of Chemistry held at Islamabad (Dec. 12, 2002), Title of paper presented, Computational Chemistry - Trends in Education and Research. Plenary Lecture delivered at 3rd International & 13th National Chemistry Conference held in Karachi (Dec.28-31, 2002). Title of paper: Computational Chemistry and Mechanism of No-Mechanism Reactions. Plenary Lecture delivered at 4th International & 14th National Chemistry Conference held in Lahore (May 16-18, 2004). Title of paper: Pericyclic Reactions on the Road to Computational Chemistry. 5th International & 15th National Chemistry Conference held in Islamabad, (Nov, 2004). Titles of presentations Combinatorial Synthesis of Chalcone Libraries as Potential Antibacterial agents (IUPAC Poster Prize in Organic Chemistry). Regiocontrolled Synthesis of Benzyl 3-Deoxy-3-Halo-and Benzyl 3-Deoxy-3-C-Allyl Pentopyranosides (Poster). Discovery of New Nickel Metalocentre spanning Inhibitors of Urease (Oral).
th

18. 19. 20. 21.

22.

11 Asian Chemical Congress and 13th General Assembly held in Seoul, Korea (Aug.23-26, 2005), Title of paper presented, Combinatorial Synthesis and Antibacterial Studies on an Indexed Chalcone Library. 10th International Symposium on Natural Product Chemistry , held in Karachi, (Jan. 06-09, 2006). Title of presentation, Synthesis and Brine Shrimp Lethality Studies on Index Chalcone Libraries. 6th International & 16th National Chemistry Conference held in Multan, (April 6-8, 2006). Title of presentation: Synthesis and antitumor activities of a parallel library of aryl and heteroaryl Chalcones. Drug Design amongst the Vines (Dec. 03-07, 2006), RACI, Australia, Title of presentation, Combinatorial synthesis and antitumor studies on a chalcone library using positional scanning protocol and CoMFA based 3DQSAR. 11th International Symposium on Natural Product Chemistry, Karachi, Pakistan, (Oct 29-Nov.01 2008, Titles of posters presented: In silico studies on 2,3-dhydro-1,5-benzothiazepines as cholinesterase inhibitors. Comprehensive 3D-QSAR studies on an array of cytotoxic chalcones

23. 24. 25.

26.

27. 5th international Symposium on Biotechnology (ISB-09), Jamshoro, Pakistan. (Oct. 4-7, 2009) In silico studies on anticonvulsant drugs. 28. 34th International Nathiagali Summer College on Physics & Contemporary Needs, Islamabad (Jun 22- Jul 4, 2009), Introduction to computer aided drug designing. 19th National Chemistry Conference (Jun, 2009), Baragali, Plenary lecture, An excursion through wet and dry labs. 30. 8th International and 20th National Chemistry Conference (Feb.15-17, 2010), Islamabad, Pakistan Peptide heterocycles: new classes of drug like molecules by ligation of peptides (oral). 11

29.

Prediction of interacting modes of Anticancer drugs with DNA using cyclic voltametric, UV visible spectroscopic and the molecular docking techniques (oral). Synthesis, bioevaluation and docking studies on antidiabetic chalcones (Poster, 1st Prize, Organic Chemistry). Synthesis and bio-evaluation of derivatives of 1,4-disubstituted-1,2,3-triazoles (poster). In silico design and synthesis of dihydropyrimidines as a new class of urease inhibitors (poster).

11th Tetrahedron Symposium , Beijing, China (Jun. 22-25, 2010), in silico modeling on specific inhibitory potential of thiophen-2,3-dihydro, 1,5-benzothiazepines against BChE in formation of -amyloid plaques associated with Alzheimers disease (Poster). 11th Eurasia Conference on Chemical Sciences, Aman, Jordan (Oct. 6-10, 2010), Triazoles at a clickRegioselective synthesis of 1,4-disubstituted-1,2,3-mono- and bis-triazoles by Cu(I) catalyzed [3+2] cycloaddition. DAAD Alumni Seminar, Pakistani and German Universities Joining Forces for a Better Future, Islamabad, Oct. 29-31, 2010, Title of presentation: Exploring various facets of medicinal chemistry.

Workshops/Expos 31. 32. National Science and Technology Fair for Self Reliance, 1992 held in Islamabad. Title of Exhibit, Educational software for students from Class I to M.Phil. Workshop on Theoretical and Computational Chemistry, organized by National Academy of Higher Education, Islamabad (Feb. 6-11, 1993). Title of paper and Exhibit, Mechanism of No Mechanism Reactions. All Pakistan Software Competition (July 29-31, 1993). Title of Exhibit: Computer Aided Lessons on Pericyclic Reactions. Science and Technology Expo-93 (Sep. 19-24, 1993). Title of Display, Educational Software for Chemistry Students. Workshop on Applications of Computers to Chemistry organized by National Academy of Higher Education, Islamabad. (Jan. 1-6, 1994). Resource Person, Title of presentation, HMO and Pericyclic reactions. Workshop on Die Grenzorbital (FMO), Theorie und ihre Anwendvng in der organischen Chemie held in Tbingen, Germany (Feb. 8-12, 1996), Title of presentation, Pericyklische Reaktionen und Ihre Mechanismus. SAARC Workshop on the Development and Production of Instructional Material in Science Education at Secondary Level, Islamabad (Oct. 8-10, 1996). Title of Display: Instructional Material for Secondary School Students.

33. 34. 35.

36.

37.

Conferences/Workshops (attended) 38. 39. 40. 41. 42. 43. First International Conference on Scientific Miracles of Quran and Sunnah held in Islamabad (Oct. 18-21, 1987). DAAD-Follow-up Seminar held in Islamabad (Mar. 27-30, 1988). 3rd. DAAD Follow-up Seminar held in Islamabad (Sep. 29-Oct.2, 1991). 10th National Chemistry Conference, held in Islamabad (Oct. 28 23, 1999). Information handling for promotion of E-Business, Workshop for Middle Management Women held at PASTIC, Islamabad (Jul 30 -Aug. 4, 2001). Seminar on Chromatography held in Islamabad (Mar 13, 2002) organized by Varian, We Brothers. 12

44. 45. 46. 47. 48.

One- Day Seminar on NMR Spectroscopy held in Islamabad (Sep.22, 2003). International Workshop on Wealth Generation through Research organized by PSF and NUST in Islamabad (Dec.03, 2003). Workshop on Combinatorial Chemistry held in Islamabad (May 07-13, 2004). Workshop on Computational Chemistry and its Applications, (June 24-27, 2006), Karachi. 1st Joint Status Seminar of the Screening Unit (FMP) and Network of Drug Discovery and Development, Berlin, Germany (Jun 4, 2008).

13

Publications
Books/Chapters 1 F. Latif Ansari, R. Qureshi, M.L. Qureshi, Electrocyclic Reactions - from Fundamentals to Research, Supplemented by Computer Aided Lessons, Wiley-VCH, Weinheim, Germany, ISBN 3-7785-2569-7, 1999. www.wiley-vch.de/books/tis/index.html). F. Latif Ansari, R. Qureshi, State of Science Education in Pakistan, Annual Review, 2002-03, Social Policy and Development Center, ISBN 969-8407-01-4. F. Latif Ansari, S. Umbreen, L. Hussain, T. Makhmoor, S.A.Nawaz, M.A.Lodhi, S.N.Khan, F. Shaheen, M.I. Chaudhry and Atta-ur-Rahman, Syntheses and Biological Activities of Chalcone and Benzothiazepine Derivatives: Promising New Free Radical Scavengers, and Cholinesterases, Urease, and -Glucosidase Inhibitors, Essays on Science, Felicitation Volume (in honor of Prof. Dr. W. Voelter, Germany), Hamdard Foundation, Pakistan, 8, 2006, 197-218.

2 3

Research Papers 1 2 3 4 5 6 7 8 9 M. Hasan, N. Khan and F. Latif, Influence of Substituents on the Stability of Five-Membered Lactone Rings, Islamabad J. Sci., 1978, 5 (1-2), 35-37. M. Hasan, M.U. Zubair and F. Latif, Preparation of Benzimidazoles as Potential Therapeutic Agents-I, Islamabad J. Sci., 1979, 6 (1-2), 34-39. M. Hasan, F. Latif and M. Amjad, Preparation of New Benzimidazoles as Potential Therapeutic Agents-II, J. Chem. Soc. Pak, 1981, 3, 111-113. M. Amjad, F. Latif, M. Hasan and N. Khan, Synthesis and Mass Spectral Studies of Benzimidazoles, J. Chem. Soc. Pak., 1984, 6(4) 235-238. New

F. Latif, M. Hasan and S. Zulfiqar, Synthesis of New Benzimidazoles as Potential Therapeutic Agents-III, Preparation of Bis-Benzimidazoles, J. Chem. Soc. Pak., 1984, 6 (3), 153-160. M. Hasan, F. Latif and M.C.G. Alvarez, Reactions of Some Unsaturated Carboxylic Acids with oPhenylene Diamine in Acid Medium I, J. Chem. Soc. Pak., 1985, 7(4), 309-313. N. Afza, A. Malik, F. Latif and W. Voelter, Synthesis of Sugar Nitrates by Nucleophilic Substitution, Liebigs Ann. Chem., 1985, 1929-1934 (Renamed as European J.Org. Chem.). F. Latif, A. Malik and W. Voelter, Expoxide Assisted Displacement of Trifyl Group by Flouride ion. An Efficient Approach to Fluorodeoxy Sugars, Z. Naturforsch, 1985, 40b, 317-318. M. Hasan, F. Latif and M.C.G. Alvarez, Preparation, Physical Properties and Nuclear Magnetic Resonance Spectral Studies of Isomeric 2 (Hyroxypropyl)-Benzimidazoles, J. Chem. Soc. Pak., 1987, 9(1), 57-6

10 F. Latif, A. Malik and W. Voelter, Efficient High-Yielding Synthesis and NMR Spectroscopic Studies of Some Fluorodeoxy sugars, Liebigs Ann. Chem., 1987, 617-620 (Renamed as European J.Org. Chem.). 11 F. Latif, A. Malik and W. Voelter, Synthesis of New Amino- and Aziridino-Sugar Derivatives of Potential Biochemical Interest, Liebigs Ann. Chem., 1987, 717-720 (Renamed as European J.Org. Chem.). 12 M.S. Sheikhani, F. Latif, A. Fatima, A. Malik and W. Voelter, Synthesis of 3,4-Dideoxy-3, 4Cyanomethylene Pyranosides: A New Class of Cyclopropanated Sugars, J. Chem. Soc. Chem. Comm., 1988, 1419-1420.

14

13 M. Hasan, F. Latif and J.V. Thuijil, Effect of Substituents on the Hydrolysis Mechanism of Lactones, Isl. J. Sci., 1990, 10 (1-2) 77-89. 14 F. Latif, M.S. Sheikhani and W. Voelter, Convenient Synthesis of Mono- and Cyclic Sulphates of Carbohydrates via Triflate Displacement, J. Chem. Soc. Perkin Trans., 1990, 1, 1573-1575 (Renamed as Org. & Biomol. Chem.). 15 A.Malik, F. Zaman, M. Akhtar, N. Naz A. Fatima, F. Latif and Y. Abed. Epoxysugars as Intermediates in Carbohydrate Synthesis, Trends in Organic Chemistry, 1993, 4, 741-772, Ed. Atta-UrRahman, Harward Academic Publishers, The Netherlands, 1992, 12, 1. 16 N. Khan, Y-Al-Abed, F. Latif Ansari, H.J. Kohlbau, W. Voelter; Regio-und Stereoselselektive Ringffnug on Epoxypyranosiden durch Isopropoxytitan-Reagenzien und Sm I2 : Ein einfacher Zugang zur Ioddesoxyzuckern. Z. Naturforsch., 1996, 51B, 1781-1789. 17 F. Ansari, C. Fedorchuk, M. Parvez, S. Umbreen S. Sagheer, Crystal Structure Report, Diastereomers of 2-Phenyl--4(2-hydroxyphenyl)-2,3,4,5-Tetrahydro-1,5-Bezothizepines, Acta Cryst., 2002, E58, 0422-0425. 18 M. Parvez, S. Umbreen and F. Latif Ansari, Derivatives of 4-(2- Hydroxyphenyl)-2,3-dihydro-1,5benzothiazepines, Acta Cryst,, 2003 , C59, 0298-0301. 19 M. Rauf, F. Latif Ansari, G. Bibi, Photocatalytic Degradation of some Azodyes, J. Fac. Sci., UAE Univ., 2004, 13, 41-45 (Renamed as Int. J. Sci. Res. University of UAE). 20 F. Latif Ansari, S. Umbreen, L. Hussain, T. Makhmoor, S.A.Nawaz, M.A.Lodhi, S.N.Khan, F. Shaheen, M.I. Chaudhry and Atta-ur-Rahman, Syntheses and Biological Activities of Chalcone and Benzothiazepine Derivatives: Promising New Free Radical Scavengers, and Cholinesterases, Urease, and -Glucosidase Inhibitors, Chem. Biodiv, 2005, 2 (4), 487-96 . 21 F. Latif Ansari, L.Hussain, S.Nasir, Electron Ionization Fragmentation Mechanisms of Different Substituted 2,3-Dihydo- and 2,3,4,5-Tetraihydro-1,5-Benzothiazepines, Rapid Commun. Mass Spectrom. 2005, 19, 1-7. 22 F. Latif Ansari, S. Nazir, H. Naureen, B. Mirza, Combinatorial Synthesis and Antibacterial studies on an lndexed Chalcone Library, Chem. Biodiiv .2005, 2, 1656- 64. 23 F. Latif Ansari , S. Sultana, Andrea M.Corrente, Masood Parvez,, 2,3,4,6-Tetra-O-acetyl-O-p-tertbutylphenyl--D-glucopyranoside, Acta Cryst, 2006, E62, 03139-03141. 24 A.Rahman, R. Qureshi,, M.Kiran, F. Latif Ansari, Electron Affinities, Solvation Energies and Redox Potentials of some Chalcones: Substituents Effects and Correlation with semi Empirical MO Energies, Turk. J. Chem, 2007, 30, 1-10. 25 Ahsan-Ullah, F. Latif Ansari, Ehsan-Ul-Haq, S. Nazir, B. Mirza, Combinatorial Synthesis and Antitumour studies on an Aryl and Heteroaryl Chalcone Library using Positional Scanning Method, Chem. Biodiv. 2007, 4, 203-214. 26 Sarfraz A. Nawaz, S.Umbreen, A.Khalid, F. Latif Ansari, Atta-ur-Rahman, M.I. Choudhry, Structural insight into the inhibition of cholinesterase by 2,3,4,5-tetrahydro-1,5-benzothiazepines, J.Enzyme Inhib. & Med.Chem., 2008, 23, 2, 206-12. 27 F. Latif Ansaria, Fatima Iftikhara , Ihsan-ul-Haqb, Bushra Mirzab Muhammad Baseera, Umer Rashida, Solid phase synthesis and biological evaluation of a parallel library of 2,3-dihydrobenzothiazepines, Bioorg. Med. Chem, 2008, 16, 7691-7697. 28 A. Shah, A.M. Khan, R. Qureshi, F. Latif Ansari, M.F. Nazar, S.S. Shah, Redox behavior of anticancer chalcones on a glassy carbon electrode and evaluation of its interaction parameters with DNA, Int, J. M .Sc. 2008, 9, 1424-1434. 29 F. Latif Ansari, Zaheer-ul-Haq,, A.Wadood, Ahsanullah, in silico studies on urease inhibitors to explore enzyme-ligand interactions,. J.Enzyme Inhib. & Med.Chem., 2009, 24 (1), 151-156. 30 F. Latif Ansaria, Muhammad Baseera, Fatima Iftikhara , Saima Kulsooma, Ahsan Ullaha, Samina Nazira, Awais Shaukata, Ihsan-ul-Haqb, Bushra Mirzab Microwave assisted synthesis, antibacterial 15

activity against Bordetella bronchiseptica of a library of 3'-hydroxy-aryl and heteroaryl chalcones and molecular descriptors-based SAR, ARKIOVC 2009 (x) 318-332. 31 A. Shah, R. Qureshi, A. M. Khan, F. Latif Ansaria, S Ahmad, Determination of binding parameters and the mode of Ferrocenyl Chalcone-DNA interaction, Bull. Chem. Soc. Jpn. (2009), 82 (4), 453-457. 32 A. Shah, R. Qureshi, R. A. Khera, F. Latif Ansari , Electrochemical behavior of 1-ferocenyl-3-phenyl2-propen-1-one on Glassy carbon electrodes and evaluation of its interaction parameters with DNA, J. Braz. Chem. Soc, 2009, 0 (0), 1-5. 33 S.S.Soomro, F.Latif Ansari, K.A.Chatziapostol, k.Koehler, Palladium leaching dependenceon reaction parameters in Suzuki-Miyaaura coupling reactions catalyzed by palladiums supported on alumina under mild reaction conditions, J. Catalysis, 2010, 273, 138-146. 34 W. Khan, Zaheer-ul-Haq, , S. Kalsoom, F. Latif Ansari, In-silico modeling on specific inhibitory potential of thiophene-2,3-dihydro-1,5-benzothiazepine against BChE in the formation of -amyloid plaques associated with Alzheimer's disease, Theor. Biol.Med. Model, 2010, 7, 1-26. 35 A. El-Dahshan, S.Nazir, Ahsanullah, F.Latif Ansari, J.Rademann, Peptide heterocycle chimera-new class of more drug-like peptidomimetics by ligation of peptide bis-electrophiles with various bisnucleophiles. Eur.J.Org.Chem, 2010, 1-11. Papers under review 1. R. Qureshi, F. Perveen, S. Ahmad, N.K. Janjua, F.L. Ansari, S. Kalsoom, Prediction on interacting modes of anticancer drugs with DNA using cyclic voltametric, UV-Visible spectroscopic and the molecular docking techniques, Bioelectrochemistry, 2009. F. Latif Ansari, S. Kalsoom, Zaheer-ul-Haq, In silico Studies on 2,3-Dihydro-1,5-Benzothiazepines as Cholinesterase Inhibitors, Chem. Biol. Drug Design, 2009. L. Jafri, F. Latif Ansari, M. Jamil, S. Kalsoom, S. Khurram, B. Mirza, Determination of Biological Activities of Some semicarbazones, Chem. Biol. Drug Design, 2009. dihydropyrimidines as novel urease inhibitors using structure-based virtual screening of an inhouse database, Chem. Biodiv. 2010. 5. F. Latif Ansari, S.Shaheen, S, Aliya Shehzadi, F.Jabeen, H.Awan, Y.Niazi, B.Mirza, Triazoles at a clickRegioselective synthesis of 1,4-disubstituted-1,2,3-mono- and bis-triazoles by Cu(I) catalyzed [3+2] cycloaddition., Aus. J. Chem, 2010.

2. 3.

4. F. Latif Ansari, U.Rashid, I.Batool, Reaz-uddin, M.Ajmal, Zaheer-ul-Haq, Design of 3,4-

6. F. Latif Ansari, S. Nazir, H. Noureen, B. Mirza, Zaheer-ul-Haq, In Silico guided design and synthesis of
cytotoxic chalcones, Chem. Biodiv., 2010.

Conference Proceedings (Published) 1. Proc. Nat. Pdt. Chem. Pak., 1988, 549-568,.Malik, A.Q. Khan, Z. Ahmed, N.H. Kazmi, K. Rehman, N. Afza and F. Latif, Some Recent Synthetic, Isolation and Spectral Studies in Natural Products. 2. International Congress on CD, Germany, 1991, 212-224.W. Voelter, A. Malik, F. Latif and J. Tschkert, CD Studies on Carbohydrate Meal Complexes. 3. Proc. Fifth. Nat. Chem. Conf., Pak, 1993, 238-241, F. Latif, I.U. Rehman, A. Malik, A Triflate Mediated Coupling of Sugars with Aza-heterocycles, 4. 19th. IUPAC Symposium on Natural Product Chemistry, 1994, 9-13.F. Latif Ansari, R. Qureshi, M. Qureshi and F.S. Qureshi, Computer Aided Lessons on Pericyclic Reactions.

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5. Proc. of the Conference Spectroscopy for Material Analysis, Islamabad, 1995, 469-473, F. Latif, Ansari, S. H. Awan and N.H. Kazmi, Synthesis and NMR Spectral Studies of Some Nucleosides and their Analogues. 6. 11th Asian Chemical Congress and 13th General Assembly, Korea (Aug.23-6, 2005), F. Latif Ansari, S. Nazir, H. Naureen, B. Mirza, Combinatorial Synthesis and Antibacterial Studies on an Indexed Chalcone Library. 7. 10th International Symposium on Natural Product Chemistry, Pakistan, (Jan. 06-09, 2006, F. Latif Ansari, S. Nazir, H. Naureen, B. Mirza, Synthesis and Brine Shrimp Lethality Studies on an Indexed Chalcone Library. 8. Drug Design amongst the Vines, Australia, (Dec.03-07,2006), F. Latif Ansari, Ahsan-Ullah, Ehsan-Ul-Haq, S. Nazir, B. Mirza, Combinatorial Synthesis and Antitumor Studies on a Chalcone Library using Positional Scanning Protocol and CoMFA based 3DQSAR.

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