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CHAPTER 10
10.1 Introduction
In the same manner that Dr. Armarly [1] proposed a practical classification to evalu-
ate the optic nerve condition by dividing the optic disc into 10 parts, and Dr. Raul Reca
[2] proposed another one dividing the optic disc into 6 parts, the confocal tomography of
the optic nerve suggests a further classification.
The previous classifications are based on an analysis of areas (relationship between
optic disc area, cup area and rim area) that can be correlated with the areas measured with
by the HRT.
The tomographic classification is mainly based on the volumes of said structures and
only secondarily on areas and other parameters. This is due to the possibility of stere-
ometric and three-dimensional analyses.
The advantage provided by volume measurements over area measurements, is that
the former are raised to the third power, while the latter are only raised to the second
power (whenever change occurs, no matter how slight, there is a greater variation if the
value is raised to the cube than if it is raised to the square).
Fig. 10.2
have a close relationship. On this account, its position must always be verified, and in a
longitudinal study, it must be checked to see that it always remains at the same level.
Fig. 10.3: Concept of normality. The value of all parameters mentioned must be within
two mean standard deviations of the normal values (normal range).
Limits of normality
rim volume min. 0.32 mm3
cup volume max. 0.12 mm3
rim area min. 1.37 mm2
cup area max. 0.60 mm2
cup shape measure max. –0.15
mean RNFL thickness min. 0.17 mm
height variation of contour line min. 0.27 mm
RNFL cross sectional area min. 0.87 mm2
does not involve optic nerve damage but they remain stable for years, which indicates a
physiological or normal decrease of the neuroretinal rim in this group of patients.
Normal
rim volume > 0.32 mm3
cup volume < 0.12 mm3
rim area > 1.37 mm2
cup area < 0.60 mm2
cup shape measure < –0.15
mean RNFL thickness > 0.17 mm
height variation of contour line > 0.27 mm
RNFL cross sectional area > 0.87 mm2
normal visual field
The normal optic disc is characterized by a slightly visible Elschnig's Ring, except in
the temporal area. Both poles have important fiber bundles, which correlate with the two
camel humps displayed by the contour line diagram (figure 10.5).
Borderline
rim volume > 0.32 mm3
cup volume < 0.12 mm3
rim area > 1.37 mm2
cup area < 0.60 mm2
cup shape measure < –0.15
mean RNFL thickness > 0.17 mm
height variation of contour line > 0.27 mm
RNFL cross sectional area > 0.87 mm2
normal visual field
In the borderline optic disc, the neuroretinal rim volume is normal by measuring the
entire disc, but if we analyze the rim volume by octants and quadrants, there is a de-
creased value in one of these sectors. The decrease of the neuroretinal rim volume in this
phase does not affect the whole optic disc. It corresponds to Burk's pseudonormal optic
disc in which the humps remain unchanged and there is a slight neuroretinal rim loss.
Except of the cup increase, no parameters are altered (this is less frequent; figure 10.6).
Phase 1
rim volume 0.32 - 0.30 mm3
cup volume 0.12 - 0.24 mm3
rim area 1.37 - 1.20 mm2
cup area 0.60 - 1.00 mm2
cup shape measure –0.15 - –0.12
normal visual field
Fig. 10.5
Fig. 10.6
Fig. 10.7
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Phase 2
rim volume 0.30 - 0.20 mm3
cup volume 0.24 - 0.48 mm3
rim area 1.20 - 0.80 mm2
cup area 1.00 - 1.50 mm2
cup shape measure –0.12 - –0.07
beginning of visual field defects
The optic disc in phase 2 has already a loss of up to 50% of the total retinal nerve fi-
bers. The disappearance of both humps, which correlates with a great cup increase that
invades the superior and the inferior poles, can be seen. The mean RNFL thickness pre-
venting the contour line from approaching the reference plane, remains unchanged (figure
10.8).
phase 3
rim volume 0.20 - 0.10 mm3
cup volume 0.48 - 0.96 mm3
rim area 0.80 - 0.40 mm2
cup area 1.50 - 1.80 mm2
cup shape measure –0.07 - –0.02
visual field defects
The optic disc in phase 3 is characterized by a great decrease of the mean RNFL
thickness, which causes the approach of the contour line towards the reference plane.
(When localized defects occur, the contour line reaches the reference plane in the dam-
aged areas.) The summation image allows the bottom of the cup and Elschnig's Ring to
be clearly seen in their full extend. The cup surface covers almost the whole the optic
disc surface. The NRR persists like a thin hale around it (figure 10.9).
Phase 4
rim volume 0.10 - 0.00 mm3
cup volume > 0.96 mm3
rim area 0.40 - 0.00 mm2
cup area > 1.80 mm2
cup shape measure >= 0
visual field in stage 3 (terminal)
The optic disc in phase 4 is characterized by a final decrease of the retinal thickness,
where the contour line diagram is parallel to the reference plane, and in the places where
there is no NRR left the contour line height variation diagram is below the reference
plane. This fact correlates with the appearance of white regions in the analysis of the
surfaces and with the presence of absolute visual field defects (figure 10.10).
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Fig. 10.8
Fig. 10.9
Fig. 10.10
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Fig 10.11
In figure 10.11, all six phases are summarized. In the normal optic disc, as well as in
the borderline disc, Elschnig’s Ring can only be seen in the temporal sector, whereas in
all other phases it can almost be seen in its full extend, due to fiber atrophy. The bottom
of the cup is more clearly seen from phase 2 on.
If the brightness of the retina in each section are observed, it is noticed that it de-
creases steadily from normality to phase 4.
The cup shape measure changes rapidly. In phase 2 the cup slope is almost perpen-
dicular, and in phases 3 and 4 bayonet-shaped vessels are revealed.
The small vessels become more and more evident and their contours are more visible
as they become more definite (this is due to the atrophy of the retinal nerve fibers).
Nevertheless, at first glance, the condition of the optic disc in phase 4 may seem
better than in phase 3. Also, the time elapsed between the normal and the borderline optic
disc, or between the borderline optic disc and the disc in phase 1 may seem the same.
This is clearly solved with a stereometric analysis of the surfaces.
Figure 10.12 shows the six phases in the "Measure" menu, with the color coded
analysis of the surfaces. In the normal optic disc, the cup is seen surrounded by a large
NRR and not centered in the optic disc. This occurs in normal conditions due to the great
entrance of fibers at the superior and inferior poles. In the borderline optic disc, it is pos-
sible to see how the cup area increases at the expense of a rim area decrease. Simultane-
ously, the cup becomes central and its area invades the tilted neuroretinal rim area, thus
reducing its separation from the flat neuroretinal rim. In the optic disc of phase 1, the cup
area continues to increase and the cup gets closer to the flat neuroretinal rim, leaving a
thin separation covered by the tilted neuroretinal rim. The total surface of the NRR de-
creases markedly. In the optic disc in phase 2, the cup increases considerably and starts to
become slightly eccentric, and the tilted rim disappears completely in these reagions.
Consequently, the cup surface borders the flat rim surface. This fact can sometimes cause
localized defects and, together with the diffuse atrophy of the rest of the retina, it corre-
lates with the onset of the visual field defects in this phase. In the optic disc in phase 3,
the cup almost covers the complete optic disc region. The tilted rim has almost com-
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Fig. 10.12
pletely disappeared. Only a thin flat rim margin separates the cup from the external optic
disc margin. This small volume of NRR keeps the visual function unchanged; this is cor-
related with the rapid visual field loss produced when the remaining NRR is damaged. In
the optic disc in stage 4, the cup has occupied almost all the optic disc surface and in
some sectors, where the NRR has been completely destroyed, the cup touches the exter-
nal optic disc margin, making the total absence of the NRR evident in that sector. White
regions can occur in stage 4 which are due to the fact that the retinal surface is below the
level of the reference plane in the most badly damaged sectors. These lesions produce
absolute optic disc defects of bad prognosis.
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Fig. 10.13
Fig. 10.14
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Case 2: Patient with 72 years of age (male), with diagnosis of chronic glaucoma
with narrow angle. The patient was treated because of hypertension for 15 years. (Intra-
ocular pressure without medication: 31 mm Hg, with medical therapy: 24 mm Hg.)
Peripherical iridectomy with YAG laser was performed. Later, trabeculoplasty with Ar-
gon laser. After these procedures, the monitoring of the intraocular pressure was done
with daily pressure curve: mean 17 mm Hg, variability 1.5. HRT presents in the left eye
optic disc in phase 2, which is in correlation with a border-line visual field (figures 10.15
and 10.16).
Fig. 10.15
Fig. 10.16
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Case 3: Patient with 57 years of age (female), left eye, with diagnosis of open angle
glaucoma and myopia. Visus: 10/20 with sph. -5.00. The intraocular pressure measured
with daily pressure curve shows a mean of 23 mm Hg, variability 1.6. The computerized
perimetry presents a visual field in stage III, with M.D. 18.9 and C.L.V. 96.4. The HRT
shows an optic disc in phase 3 (figures 10.17 and 10.18).
Fig. 10.17
Fig. 10.18
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Case 4: Patient with 65 years of age (female), with diagnosis of open angle glau-
coma, made 20 years ago. The trabeculoplasty was performed 5 years ago. The monitor-
ing of intraocular pressure was made with spot check pressure and not with daily pressure
curve. The pressures taken by other ophthalmologists were 25 mm Hg. The actual visus
with a correction of sph. 0.75 is 18/20. Computerized perimetry shows a visual field in
stage III., with M.D. 23.2 and C.L.V. 60.5. The HRT shows an optic disc in phase 4,
where the only retinal nerve fiber bundle present is the papillo-macular one (figures
10.19 and 10.20).
Fig. 10.19
Fig. 10.20
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Bibliography
1. Armarly MF: Genetic determination of cup/disk ratio of the optic nerve. Arch.
Ophthalmol 1967;78:35-43.
2. Reca R: In: Sampaolesi R (ed.): Glaucoma; Edit. Panamericana, Buenos Aires, Ar-
gentina, 1991, pp. 305-306.
3. Sampaolesi JR, Sampaolesi R: Lecture: Study of normality in the optic nerve head
with HRT, in “Curso y Simposio Argentino de Glaucoma, July 1995, Buenos Aires,
Argentina.
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