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Tutorials 1: J Pharm Belg. 1989 Mar-Apr;44(2):109-16. Related Articles, Links

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E-Utilities Potentiation of therapeutic effect of methanesulphonate and protection against its organ
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cytotoxicity by vitamin C in Ehrlich ascites carcinoma bearing mice.
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MeSH Database el-Merzabani MM, el-Aaser AA, Osman AM, Ismael N, Abu el-Ela F.
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Clinical Queries The effect of vitamin C upon the therapeutic index and side effects produced by methanesulfonate of
Special Queries aminoglycols (drug 864T, NSC 140117) had been evaluated in a laboratory system. The antitumor action of
LinkOut 864T, vitamin C and their combination were evaluated in Ehrlich ascites carcinoma (EAC) cells in vivo. Tissue
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toxicity was assessed using liver and intestinal DNA, RNA, protein contents and their synthesis as
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parameters. In addition, G-6-pase, 5-Nase and Alk, pase activity levels in both tissues were also measured.
Order Documents Drug 864T (200 mg/kg) produced 50 percent long-term survivors in tumor bearing mice in addition to 10
NLM Mobile percent early mortality while in combination with vitamin C (250 mg/kg x 6), there was 80 percent long term
NLM Catalog survivors with no mortality related to drug toxicity. No toxicity, in all the parameters used, was observed
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TOXNET when 864T was given in combination with vitamin C. Drug 864T alone produced a significant decrease in
Consumer Health protein content of both liver and intestinal tissue while in combination with vitamin C normal levels were
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ClinicalTrials.gov maintained. In addition, all the parameters used were either elevated or decreased by 864T treatment and
PubMed Central returned to normal levels in combination with vitamin C. This study proved that vitamin C may be useful not
only to potentiate the effect of anticancer drug 864T on the Ehrlich ascites carcinoma but also to antagonize
the side effects of the drug.

PMID: 2550606 [PubMed - indexed for MEDLINE]

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