You are on page 1of 1

A service of the U.S.

National Library of Medicine

and the National Institutes of Health
[Sign In] [Register]

All Databases PubMed Nucleotide Protein Genome Structure OMIM PMC Journals Books
Advanced Search
Search PubMed for Go
Limits Preview/Index History Clipboard Details

Display AbstractPlus Show 20 Sort By Send to

All: 1 Review: 0

1: Exp Toxicol Pathol. 1992 Mar;44(1):3-9. Links

Ultrastructure and cell surface studies of cancer cells following vitamin C administration. Related Articles

Inhibition of DNA synthesis and neoplastic cell growth by vitamin

Lupulescu A. A (retinol). [JNatl Cance rI nst. 1986]

Department of Dermatology, School of Medicine, Wayne State University, Detroit, MI. Chemoprotective effect of progesterone on carcinoma formation
in mice and rats. [JNatl Cance rI nst. 1985]
Basal cell carcinomas in rats and squamous cell carcinomas in mice induced by a topical administration of a
Vitamin C inhibits DNA, RNA and protein synthesis in epithelial
chemical carcinogen 3-methylcholanthrene (MCA) a single dose of 800 micrograms, were significantly reduced neoplastic cells. [ IntJ Vitam Nutr Res. 1991]
in number and size following a combined administration of vitamin C, a daily dose of 50 mg/kg b.wt. and MCA for
9 months. Ultrastructural studies of basal cancer cells and squamous cancer cells revealed an advanced Reserpine and carcinogenesis: inhibition of carcinoma formation
cytolysis and disorganization of neoplastic cells, mitochondrial alterations, nuclear and nucleolar reduction, and in mice. [JNatl Cance rI nst. 1983]

increased phagolysosomes formation, following vitamin C and MCA administration compared to that of Enhancement of epidermal carcinoma formation by prolactin in
neoplastic cells following MCA alone. Scanning electron microscopic observations also revealed cytolysis, mice. [JNatl Cance rI nst. 1985]
increased collagen synthesis, and cell disorganization with membrane disruption following vitamin C and MCA » See All...
administration, as compared to round basal neoplastic or polyhedral squamous neoplastic cells following MCA
treatment alone. These findings demonstrate that vitamin C exerts its antineoplastic effects by increasing
Cited by PubMed Central article
cytolytic and autophagic activity, cell membrane disruption, and increased collagen synthesis, and thus,
inhibits cancer cell metabolism and proliferation. Effect of physiological concentrations of vitamin C on gastric
cancer cells and Helicobacter pylori. [ Gut. 2002]
PMID: 1392514 [PubMed - indexed for MEDLINE]

Patient Drug Information

Ascorbic Acid (Cecon® Drops, Cenolate® , Cevi-Bid® , ...) Ascorbic acid is used
to prevent and treat scurvy, a disease caused by a lack of vitamin C in the body.

Source: AHFS Consumer Medication Information

Recent Activity
Turn Off Clear

Ultrastructure and cell surface studies of cancer cells following vitamin C


Potential protective effect of vitamin C on carcinogenesis caused by

nitrosamine in drinki...

Characterization of a new malignant human T-cell line (PFI-285) sensitive to

ascorbic acid...

Dietary vitamins A, C, and E and selenium as risk factors for cervical cancer.

Display AbstractPlus Show 20 Sort By Send to

Write to the Help Desk
Department of Health & Human Services
Privacy Statement | Freedom of Information Act | Disclaimer