there is evidence of dentigerous cyst formation occurring in association with impacted third molars.

7 In most cases there is a strong indication for removal of the third molar in order to prevent expansion or recurrence of a keratocyst.43(scottish)

Cysts and odontogenic tumors derive from epithelial cells in oral tissues such as remnants of odontogenic epithelium in the tooth follicle and the epithelial lining of the oral mucosa [16]. Recent studies provide data on the expression of cell proliferation markers in odontogenic epithelial remnants and epithelium of odontogenic cysts [6, 1618], and of apoptosis-related factors in PF of lower third molars [6]. The primitive dental sac, or dental follicle, which originates from odontogenic ectomesenchyme, is part of the tooth germ and is physiologically involved in the formation of cemen- tum, the periodontal ligament, and alveolar bone. Once the tooth has fully developed inside the jaw, the coronal part of the follicle is termed pericoronal sac or follicle (PF) and occa- sionally persists adjacent to the crown of unerupted or im- pacted teeth Laura Villalba, 2012

Radiographically, the dentigerous cyst appears as a unilocular radiolucency of variable size with well-defined sclerotic border, associated with the crown of an unerupted tooth. Histologically, the dentigerous cyst displays a thin fibrous cyst wall with a myxomatous appearance. The epithelial lining consists of 2-4 layers of fat or cuboidal cells, which in fact is the reduced enamel epithelium and is characteristically nonkeratinized. (yaman, 2011)

The cyst arises from the separation of the follicle from the crown of an unerupted tooth, Radiographs show a unilocular, radiolucent lesion characterized by well-defined sclerotic margins and associated with the crown of an unerupted tooth. While a normal follicular space is 3 to 4 mm, a dentigerous cyst can be suspected when the space is more than 5 mm. J Can Dent Assoc 1999

Prior to completion of odontogenesis, both the primary and secondary dental laminae disappear. Any remnants of these embryonic cells may give rise to both benign and malignant lesions later in life. The enamel epithelium surrounding the crown proliferates, and fluid collects between the layers. (Dunfee, 2006)

The dentigerous cyst is caused by fluid accumulation between the epithelium and the crown of an unerupted tooth.8-10 These cysts are the second most common odontogenic cysts after radicular cysts. Their frequency in the general population has been estimated at 1.44 cysts for every 100 unerupted teeth.10 It grows by expansion of the follicle and is attached to the neck of the tooth.8 Some of these lesions contain from proliferating of the cell rests of Malassez epithelial.3,11 It is believed that epithelial which is derived from the cell rests of Malassez lines the lumen of the dentigerous cysts.3 Dentigerous cysts may cause displacement of adjacent teeth and resorption of teeth roots. (Aslan, 2006)