Sie sind auf Seite 1von 2

The Fetal Medicine Foundation

List of changes to the First Trimester Screening module.

The Fetal Medicine Foundation is releasing an improved 1 st Trimester algorithm (FMF 2012). Unchanged: background risks for aneuploidies risks for aneuploidies by nuchal translucency risks for aneuploidies by nasal bone and tricuspid flow risks for aneuploidies by major ultrasound markers

Removed: frontomaxillary facial angle minor ultrasound markers built-in contingent screening (omitting the use of ultrasound markers when the risk by NT or NT+Biochemistry exceeded a cutoff).

Biochemistry: PlGF added as a marker for aneuploidies, preeclampsia and fetal growth restriction Gestational age-dependent factors for racial origin, smoking and method of conception Diabetes mellitus (type 1 or type 2) added as an adjustment factor MoMs from a previous normal pregnancy can adjust distributions

New markers: ductus venosus PI

Pregnancy complications: an improved algorithm for preeclampsia using maternal history and pregnancy characteristics and any combination of uterine artery PI, mean arterial pressure, PAPP-A and PlGF a new algorithm for fetal growth restriction using maternal history and pregnancy characteristics and any combination of uterine artery PI, mean arterial pressure, PAPP-A and PlGF a new algorithm for spontaneous preterm delivery using maternal history and pregnancy characteristics and endocervical length

For more information about new markers and algorithms, please see the document Guide for the First Trimester Screening module.

astraia software

June 2012

Other new features:

risks are reported in a text panel giving a better presentation, especially in multi-fetal pregnancies operator licenses can be automatically updated if internet access is available redundant operators can be deleted printout of racial origin can be suppressed printout of risks for preeclampsia, fetal growth restriction or preterm delivery can be suppressed

Risk cutoffs:

all risks above the cutoff are reported in bold the risk cutoff for trisomy 21 is configurable, as before. The default is 1:100. a risk cutoff (default 1:50) for trisomy 18+13 has been added risk cutoffs for preeclampsia and fetal growth restriction are calculated by the program, depending on the markers used

Audit module:

analytes are grouped in their own tabbed pages PlGF and AFP added new pages for log10MoM uterine artery PI, log10MoM ductus venosus PI, log10MoM MAP an initial dialog to choose operator and date range (for databases with >10000 cases this will speed up the audit data collection process)

Software changes fixed a problem when installing into Program Files on recent Windows versions increased the program memory allocation to 500 MB to help with queries on large databases centre id added to license panel (principally for Australian users)

What happens to examinations which were calculated with previous risk algorithms? If you open an old examination where the risks have been already calculated with pre- FMF 2012 algorithms the software recognizes this and will not re-calculate the risks with the new algorithm. These risks will remain and the respective data fields are set to read-only. This is to ensure that you can always see the risks as they were given in the original examination with the original settings at that time. This is important for data security to avoid misleading changes in the database and to ensure correct handling of old data in your statistics and 1st trimester audit. FMF license There is no change to the FMF license your license file will continue to work! The license for facial angle is ignored, as this is no longer available in the software. astraia software June 2012