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1) Which of the following enzyme catalyze transbilayer translocation?

a) Flipase c) scramblase b) Floppase d) All of the above 2) Which of the following lipids are very important on the extracellular leaflets in order to trigger the apoptosis? a) Phosphatidylserine c) phosphatidylethanolamine b) Phosphatidylcholine d) phosphatidylglycerol 3) which of the following statement is true regarding FRAP (fluorescence recovery after photobleaching)? a) The proteins in the outer leaflets of the plasma membrane are labeled with fluorescent probe. b) It is used to measure the rate of lateral diffusion of the lipids. c) UV rays are used to bleach the membrane surface. d) None of the above. 4) Lipids raft is enriched with a) Glycolipids and sphingolipids b) Phospholipids alone c) glycerophospholipids d) cholesterol and sphingolipids

5) Caveolin is a a) Peripheral protein with a single globular domain connected by a hairpin shaped domain. b) Unusual raft which involve only the inner leaflet of the bilayer. c) Implicated in variety of cellular functions such as membrane trafficking within the cells. d) Having 4 fatty acyl moieties in its dimer 6) Clostridium botulinum toxin is a protease which a) Cleaves the neurotransmitters and causes death b) Cleaves the receptors of the acetylcholine on the plasma membrane. c) Cleaves the SNARE and SNAP25 complex d) All of the above 7) Which of the following integral proteins on the RBC are important for the blood clotting process? a) Integrins c) selectins b) Cadherins d) all of the above 8) The energy cost of pumping an uncharged solute against a 1 X 10^4 fold concentration gradient at 25C is a) 14 kJ/mol c) 23 kJ/mol b) 30 kJ/mol d) 150 kJ/mol
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9) The rise per residue of helix is about 1.5 . A protein spans 4 nm bilayer 7 times through its transmembrane - helical domain. Approx, how many AA residues constitute the transmembrane domain of the protein? a) 105 c) 30 b) 450 d) 190 10) Match the following A) Shaker protein B) Bacteriorhodopsin C) Porin D) ABC transporter a) b) A-4, B-2, C-3, D-5 A-6, B-1, C-5, D-4 1) inner membrane receptor 2) active transport 3) voltage gated K+ channel 4) light driven H+ pump 5) Membrane fusion 6) barrel simple diffusion channel c) A-5, B-3, C-4, D-6 d) A-3, B-4, C-6, D-2

11) The following reagent will NOT release the integral protein from the plasma membrane a) NaCl c) Triton X-100 b) SDS d) NP-10 12) What property of the biomembrane is responsible for their self sealing nature? a) Hydrophilicity of the phospholipid head group b) Presence of protein in biomembrane c) Presence of cholesterol in biomembrane d) Hydrophobicity of fatty acid side chains of the phospholipids

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