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# 1. A nitrogen atom has 3 single electrons and 1 lone pair. Hydrogen has one electron.

The structure in C correctly shows each nitrogen with three bonds and a one lone pair. Each atom in this molecule has a full outer shell of electrons and all electrons are present. 2. Equation 1 shows that the Raschig process requires the reaction of 2 moles of ammonia to form 1 mole of hydrazine. The molar mass of ammonia is 17 g/mol (14 + 1 + 1 + 1). Therefore 34 g of ammonia is required to form 1 mole of hydrazine. 3. The passage states that the formula for hydrazine hydrate is N2H4H2O. The formula weight for hydrazine is 32 g/mol (14 x 2 + 4 x 1). The formula weight for hydrazine hydrate is 50 g/mol (32 + 2 x 1 + 16). The percent by weight of hydrazine in the hydrate would be 32.0/50.0 x 100%. 4. The reaction shows the formation of hydrazine from its elements. The value of Hf for a substance is the enthalpy change when one mole of that substance is formed at 1 atm pressure and 25C from the elements in their stable states at that pressure and temperature. Table 1 shows that Hf for hydrazine is 50.6 kJ/mol, therefore, the enthalpy change for the reaction shown would be 50.6 kJ/mol. 5. The basicity constant is a measure of the strength of a base. It is the equilibrium constant for the reaction of the base with water. The lower the value of Kb, the weaker the base. 6. In order for a reaction to be a spontaneous process, the value for Go must be less than 0. 7. Because there are 3 reactant moles, all liquids, and 7 product moles, all gases, the entropy increases in this reaction. Gas molecules have more freedom and randomness, and therefore higher entropy. 8. Since the ions are thousands of times more massive than the electron, answer B is justified (the hydrogen ion is the lightest ion and is nearly 2000 times more massive than the electron). An ion with so much mass compared to an electron will not be able to respond quickly because of its inertia. 9. The potential energy of an oscillatory motion is kx2 where x is the displacement. Since the maximum displacement occurs at A and C, answer D is justified. 10. The frequency is given by 9n0.5. With n = 1018, n0.5 = 109. Thus, frequency is 9 *109, which is answer C. 11. Wavelength is given by speed/frequency = 3 *107/109 or 3*10-2 m. This is the same as 3 cm or answer A. 12. This is basically a conservation of energy question. As the electrons move from A to B they convert potential energy into kinetic energy (mv2) and gain velocity and hence momentum (mv) as they do so. This momentum is just enough to allow the electrons to go from B to C; i.e. the kinetic energy reconverts to potential energyjust equal to the amount of potential energy at point A.

13. This is basically a conservation of energy question. As the electrons move from A to B they convert potential energy into kinetic energy (mv2) and gain velocity and hence momentum (mv) as they do so. This momentum is just enough to allow the electrons to go from B to C; i.e. the kinetic energy reconverts to potential energyjust equal to the amount of potential energy at point A. As the electrons move from A to B they convert potential energy (kx2) into kinetic energy (mv2), where x is the displacement from point B. It is conservation of energy. 14. The passage states that silicon cannot be purified by electrolytic techniques. These techniques involve isolating silicon from silicate minerals by decomposing the minerals with an electrical current. It would follow that the silicon could not be purified by electrolytic techniques if the minerals do not decompose easily. 15. Silicon is the fourth element in the third row of the periodic table and has 14 electrons. The first 10 electrons would have the same electron configuration as Ne. The next 2 electrons would fill the 3s orbitals and the last 2 electrons would begin to fill the 3p orbitals following Hunds Rule (electrons will not pair up until each orbital in that sublevel has 1 electron.). The unpaired electrons have parallel spins. 16. According to VSEPR theory, 4 electron pairs around an atom will result in a tetrahedral geometry. 17. Elements in the same group share chemical properties. Because potassium is a Group 1 element, one would assume that sodium, another Group 1 element would be the best substitute. 18. Van der Waals forces are weak intermolecular attractive forces. The relatively low boiling point of the SiCl3H indicates that the intermolecular forces are not strong and are most likely van der Waals forces. 19. Fractional distillation can be used for purification when the components to be separated have different boiling points. 20. A1 and A2 represent the nuclear masses of the fragments of fission. This is given by the sum of their proton and neutrons. Since the reaction started with 236 nucleons and three neutrons were 3 = 233 mass units ortaken away the sum of the fragments must contain 236 nucleons. 21. This reaction is exactly a reproduction of the statement of beta decay as given in the stem. We see the new nucleus, a beta particle (an electron) and a neutrino. The new nucleus is one atomic number higher because of the emission of the electron leaving an extra proton in the nucleus. 22. The relative rate of decay for Ra compared to Pu is the inverse ratio of their halflives or 24000/1600 = 15. This is answer B. 23. The total volume held by 106 kg of ash would be (106 kg/1000 kg/m3) = 1000 m3. This volume is held in a cube 10 m on a side since (10 m)3 = 1000 m3. This is answer B.

24. The value for Eocell is equal to the sum of Eo of the half reactions. -1.23 + 0.34 = -0.89 V. 25. The ideal gas law makes the assumption that molecules have no volume. This assumption is adequate when the gas is at 1 atm, but when the pressure is increased to 500 atm the volume of the gas molecules is no longer negligible. 26. 26. velocity.Power P is force Since speed v is fixed we must compare the forces F and Ft. The force is the coefficient of friction between tiresmg, where on the level road F is by notingand road. We can find

## Now the force required to be overcome in going uphill Ft is

The power in t his case, Pt, is Ft v. The extra power needed is then Pt minus the original power P or:

Since cos 10o 1, This is answer D. 27. 27. Light slows down because the index of refraction in the glass is greater than in the air. The index is a measure of the ratio of the velocity in air to the velocity in the medium. For sound the speed becomes greater because the speed of sound in a solid is much greater than in air (the glass has stiff rigid bonds which gives rise to a speed more than 10 times greater than in air). 28. The passage states that the reaction is zero order with respect to bromine indicating that bromine is not involved in the rate determining step. If the reaction proceeds by the same mechanism with chlorine, then the reaction with chlorine will have the same rate as it does with bromine because it would be zero order with respect to chlorine.

29. The passage states that the reaction is zero order with respect to bromine, therefore bromine can be removed from Equation 2. A comparison of the results for Experiments 2, 4 and 6 (all with acetone concentrations of 0.80 M) shows that after dividing the rates of the reactions by the rate constants, the values obtained are directly proportional to the H+ concentration indicating the reaction is first order in H+.The passage states that the reaction is zero order with respect to bromine, therefore bromine can be removed from Equation 2. A comparison of the results for Experiments 2, 4 and 6 (all with acetone concentrations of 0.80 M) shows that after dividing the rates of the reactions by the rate constants, the values obtained are directly proportional to the H+ concentration indicating the reaction is first order in H+. 30. The passage states that the reaction is zero order with respect to bromine, therefore bromine can be removed from the expression. If the reaction is first order with respect to acetone and hydronium ion, then a = 1 and c = 1. 31. The passage states that the density of acetone is 0.791 g/mL and the molar mass is 58 g/mol. The molarity of pure acetone can be calculated as follows: (0.791 g/mL)(1000 mL/L)(1 mol/58 g) = 13.6 mol/L

32. Light in the visible region of the spectrum ranges from approximately 400 nm to 700 nm. The next region of light, below 400 nm is the ultraviolet region. 33. This is found as the difference between 894 MHz and 824 MHz since these are given as the upper and lower frequencies. This is 70 MHz and is answer C. 34. Since power P is current I multiplied by voltage V, V = 12 Volts, and the maximum power is 3 watts, then the current I must be 3/12 or 0.25 A. This is answer C. 35. This answer is implied by the passage. The conversations must be on different frequencies to be unique and so no two frequencies can be used by different phones at the same time. 36. Here we must calculate P/r2. The maximum value occurs for answer D. The intensities are: A. (0.6/4) W/mile2 = 0.15 W/mile2 B. (0.6/9) W/mile2 = 0.067 W/mile2 C. (3/25) W/mile2 = 0.12 W/mile2 D. (3/16) W/mile2 = 0.19 W/mile2, making D the key.

37. Light is a transverse wave with its electric and magnetic fields oscillating at right angles to the propagation vector where as sound is a longitudinal pressure wave. This comes from prior knowledge brought to bear on the problem. Answer A correctly states the result. 38. The two plates of the capacitor collect charges of opposite sign. As more charge arrives it is harder and harder to fill the plates until finally an equilibrium occurs, thus C is correct. 39. As the capacitor discharges the voltage across it falls, thus to maintain a constant current, R must be proportionately reduced. This is so from Ohms law, I = V/R. To keep I fixed, R must fall with V. This is answer B. 40. Since energy is lost by heating the small resistor, r, the energy stored in the capacitor must be less than the work done by the battery during the charging process. The battery supplies the energy for both processes and answer B is justified. 41. The capacitor charges up and stores energy in the electric field between the places. The energy stored is CVc2, where Vc is the voltage across the capacitor. The battery is the source of energy for the circuit and thus is a store of energy. The resistor is not a storage device for energy and answer C is the correct answer. 42. With 12 Volts initially across the capacitor during its discharge (the capacitor will charge to the battery voltage of 12V) and a current of 0.002 A as found in Figure 2, then the initial . This is answerresistance R must have been R = V/I = 12/0.002 = 6000 D. 43. The rate law for Reaction 3 is second order with respect to hydrogen ion. At a pH of 1 the hydrogen ion concentration is 1x10-1. When the pH is increased to 2, the hydrogen ion concentration is 1x10-2. Because all other conditions remain the same, the rate is decreased: (1 x 10-2)2/(1 x 10-1)2 or 1 x 10-2 times. The rate would therefore be (1.0 x 10-2 M/s) x (1 x 10-2) or 1 x 10-4 M/s. 44. No kinetic information is given for Reactions 1 and 2, only equilibrium constants. 45. Reaction 1 requires that a reaction takes place between two anions which would experience electronic repulsion due to their negative charges. Protonation of the oxygen would generate an electrically neutral species and the repulsion forces would be reduced. 46. The passage states that the reaction of H218O and SO3 is fast. Singly labeled SO4-2 would be prepared most quickly by reacting the unlabeled SO3 and the labeled H2O. 47. In this reaction the oxygen is transferred from the chlorine to the nitrogen. The transition state shown in Foil C is the only transition state that indicates the bond

between the chlorine and oxygen breaking and a new bond between the oxygen and nitrogen forming. 48. The passage states that the Sequences I and III in Reaction 3 are fast and Sequence II is slow. This indicates that Sequence II would have the highest energy barrier, as is shown in the energy diagram in Foil B. 49. A substance boils when enough heat has been supplied to overcome the intermolecular forces. The fact that ammonia has a higher boiling point that phosphine indicates that ammonia requires more heat to overcome the intermolecular forces than does phosphine and therefore the intermolecular forces in ammonia are stronger than those in phosphine. 50. Density is mass/volume. The densities of the four objects are: A.(1.5/0.50) = 3.0 g/cc B.(3.0/0.75) = 4.0 g/cc C.(4.5/1.00) = 4.5 g/cc D.(6.0/1.50) = 4.0 g/cc Thus, answer C with 4.5 g/cc has the highest density. 51. Chlorine needs 1 electron to fill its outer shell. 52. The ammonium ion is an acid. It is a proton donor. 53. This is a Snell Law problem: where the ns are the indices of refraction. Taking the index of refraction of air to be nearly 1 then:

This is answer B. 54. According to the information in Table 1, the solution would contain 37.7 g Pb(NO3)2/100 mL H2O. The molality (mol solute/kg solvent) can be calculated as follows: (37.7 g Pb(NO3)2/100 mL H2O) x (1000 mL H2O/1 kg H2O) x (1 mol Pb(NO3)2/331 g Pb(NO3)2) = 1.14 mol Pb(NO3)2/kg H2 O = 1.14 m. 55. 55. The passage states that the freezing point depression constant for water is Kf = -1.86oC/m. A solution that is 10.75 m ethylene chloride would lower the freezing point of water by 1.86oC/m x 10.75 m or 20.0oC. The freezing point of water is 0oC, so the freezing point of the solution would be 0oC - 20.0oC or -20.0oC. 56. 56. The freezing point depression depends on the number of particles in the solution. A 0.1 M solution of lead nitrate would have a particle concentration of 0.3 M (1 mole of lead ions and 2 moles of nitrate ions for each mole of lead nitrate) while a 0.1 M solution of ethylene glycol would have a particle concentration of 0.1 M. The lead nitrate would therefore have a 3-fold greater effect on the freezing point of water. 57. 57. Ethylene glycol has two alcohol functionalities making it a polar molecule. Water is also a polar molecule. Table 1 shows that ethylene glycol is infinitely

soluble in water at both temperatures. Thus the like dissolves like generalization applies while temperature dependence of solubility generalization does not. 58. 58. The interstitial fluid is hypertonic, meaning that the concentration is greater in the interstitial fluid than in the cellular fluid. There will be an osmotic effect because the cell wall is a semi-permeable membrane. Solvent will pass through the cell wall from the cell to the interstitial fluid resulting in an increase in the concentration of the cellular fluid. 59. 59. Table 1 shows that lead nitrate has a solubility of 37.7 g/100 mL H2O at 0oC. The solution described in the stem would be saturated with 1.3 g (39.0 g - 37.7 g) of undissolved lead nitrate remaining. 60. The mole fraction can be determined as follows: 10 g Pb(NO3)2 x (1 mol Pb(NO3)2/331 g Pb(NO3)2) = 0.03 mol Pb(NO3)2 90 g H2O x (1 mol H2O/18 g H2O) = 5 mol H2O Mole fraction = 0.03 mol Pb(NO3)2/(0.03 mol Pb(NO3)2 + 5 mol H2O) = 0.006 61. 61. Since acceleration is the rate of change of velocity, Case II will have the lower acceleration (or deceleration). It will be in the ratio of the inverse times or (0.1/0.25) or 0.4. This is answer B. 62. 62. Each car has kinetic energy of mv2. Thus the total kinetic energy transformed into heat and deformation is 2 (mv2) = (1000)(20)2 = 400,000 J. This is answer B. 63. 63. Certainly the change in the coefficient of friction as one goes from soft rubber to hard would not influence the required tire pressure. Thus answer D is correct in that we expect this prediction not to hold. 64. 64. This answer follows directly from the passage. Without the spring the collision time will be short making the deceleration and the resulting force large. The spring absorbs some of the energy and is set into oscillatory motionthis will increase the net time of the collision. Thus the answer is A. 65. 65. The passage tells us that during each second Car A travels 30 m and Car B travels 20 m. To make up 100 m the two cars must travel 10 seconds. This is answer D. 66. 66. Since momentum is conserved and is given by mass multiplied by velocity we have mv + MV = (m + M) Va, where v and V are the initial velocities of cars A and B and Va is the velocity of both after the inelastic collision. So

67. 67. Since we would expect the quake information to propagate in all directions, it does not support the coincidence hypothesis to learn that subsequent quakes occurred in all directions. The other three answers all stress the possibility of coincidence. 68. 68. Lasting deformations go as (L/d)3 according to the passage. Thus for two different values of d, d1 and d2, the ratio of lasting deformations will go as (d2/d1)3. This value will be (4/16)3 = (1/4)3 = 1/64. This is answer C. 69. 69. Answer A certainly makes sense qualitatively. The relatively small trigger unleashed a quake that was basically ready to go with a small provocation. Answer B sounds good but the passage argues against elastic oscillations causing lasting deformations. Answers C and D make no sense and are wrong. Thus A is the best answer. 70. 70. The speed of a wave v is given by its wavelength divided by its period T:

The order of magnitude is then thousands of meters per second or answer B. 71. 71. The Doppler Effect will cause a bunching or squeezing of the waves moving with the rupture and an elongation of the waves opposing the rupture. This is answer C. 72. 72. The difference in pressure in a fluid on Earth is: (change in g (density of fluid) height) = (1000)(10)(0.25) = 2500 N/m2 This is answer C. 73. 73. The reaction equation shows the reduction of H+ by Cd. Because the H+ accepts the electron readily from Cd, it can be determined that H+ has the highest electron affinity. 74. 74. According to the relation given in the passage, the energy of an electron in orbit n = 3 is less negative or greater than the energy in orbit n = 2. Thus energy is required to make the transition from n = 2 to n = 3 and the atom gains energy. Answer D states precisely this and only D is consistent with this result. 75. 75. To find the relative refractive index to air one needs both the incident and refracted angles. Since the angle of incidence is equal to the angle of reflection we will know the angle of reflection. We still must know the angle of refraction and this is answer B. None of the other answers will allow one to know the angle of refraction. 76. 76. A faraday is equal to one mole of electric charge. Because each aluminum ion gains 3 electrons, 0.1 faraday of charge will reduce 0.1/3 moles of aluminum, or 0.033 moles of aluminum.

89. 89. The context of the phrase indicates that it refers to the inability of artists before Czanne to effectively depict reality: One might conclude from the history of art that reality in this sense is a will-o-the wisp, an actuality we can see but never grasp. Prior to this statement, the author had discussed how reality had eluded artists before Czanne, including through the use of the system of perspective: like a map, [perspective] serves to guide the intellect; perspective does not give us any glimpse of the reality. 90. 90. The author asserts Greek and Roman art was possessed of a desire to represent the world as it really is without offering specific examples or discussion of exactly how Greek and Roman artists attempted this. 91. 91. The key to the authors point about Czanne is the influence Czannes persistence exerted on modern art: There is no doubt that what we call the modern movement in art begins with the single-minded determination of a French painter to see the world objectively. The author, referring to Czanne, discusses the persistence of great revolutionaries in pursuing an idea. Near the end of the passage, the author reinforces this point, saying, But Czannedid not despair of succeeding where his predecessors had failed. 92. 92. The author asserts in the beginning of the passage that Czanne founded the modern movement with his single-minded determinationto see the world objectively and later implies that Czannes contribution to art was revolutionary. This discovery would represent a strong challenge to the authors premise. 93. 93. The argument that extra-visual faculties enabled artists to interpret their perception of the world through art is one of the most fully developed in the passage. The author discusses the role of imagination in creating an ideal space occupied by ideal forms and the role of intellect in creating a scientific chart, a perspective in which the object could be given an exact situation. The author also says that these faculties helped guide the intellect but did not grasp objective reality.

94. 94. The author is explicit on this point, drawing a direct analogy between maps and the system of perspective: But a system of perspective is no more an accurate representation of what the eye sees than a Mercators projection is what the world looks like from Sirius. Like a map, it serves to guide the intellect. 95. 95. The poetic qualities of the passage occur in the emphasis on vivid physical descriptions and imagery that appeal to the senses or the emotions rather than reflect scientific accuracy: this sunflower became incredibly beautiful, subtly turning its face daily, always toward the light, its black center alive with a deep blue light, as if flint had sparked an elemental fire there; bees with legs fat with pollen, grasshoppers with clattering wings and desperate hunger; I

never learned the sunflowers golden language. The author observes both changes and orderly occurrences, one example being the bamboo that flowers once a century on the same day no matter where they are located. 96. 96. One example in the passage where cyclical regularity occurs is with the bamboo that blooms once a centuryall plants, no matter their location, bloom on the same day by some special hidden mode of communication. The author observes: Some current we cannot explain passes through this primitive life. Each with a share of communal knowledge, all are somehow one plant. 97. 97. Prior to describing the sandstorm and the dead horse, the author observes: Changes also occurred in the greater world of the plant. The sandstorm particularly had an impact, drying out and blowing away the petals before another change came: Then birds arrived to carry the seeds to the future. The author in non-judgmental fashion simply observes these changes as necessary, especially birds carrying the seeds away, with the implication being that this is a means by which new flowers are planted. 98. 98. Nowhere does the passage suggest humans will satisfy their curiosity about nature. The tone of the passage reflects the authors sense of wonder at the variety and tumult of life in its changing and recurring patterns, especially the more aware a person becomes. This is reflected in the following: Sometimes you can hear the language of the earth. Once, in the redwood forest, I felt something like a heartbeat, a hardly perceptible current that stirred kinship and longing in me. The final paragraph, especially, touches on the notion that human wonder and curiosity before the natural world will never cease, but is passed on though the ages: Without written records, they registered the passage of the gods of night, noting the fine details of the world around them and the immensity above them. The author shares this sense of wonder with ancestors: Behind me, my ancestors say, Be still. Watch and listen. You are the result of the love of thousands. 99. 99. The emphasis in the passage is on symbiotic relationships: the sunflower as a host to various insect species, birds carrying away the seeds of the sunflower. The further implication of this is that these symbiotic relationships in nature continue even with human land use. Another implication in the passage and in final paragraph is that humans can know, appreciate, and become a part of the natural world and its symbiotic relationshipshuman awareness of these relationships may even be the key to their continuation. 100. 100. The major emphasis in the passage, especially in the tone and attitude, is the author observing and learning from nature, culminating in the final paragraph with the author participating in the collective knowledge and wisdom of previous generations: Tonight I watch the sky, thinking of the people who came before me and their knowledge of the placement of stars. Whichever road I follow, I walk in the land of many gods. Behind me my ancestors say, Be still. Watch and listen. 101. 101. The sense of unity is communicated by the authors word choice, in particular, kinship: Once, in a redwood forest, trees, I felt something

like a heartbeat, a hardly perceptible current that stirred a kinship and longing in me. Other word choice, such as heartbeat, implies that the authors kinship is with some of the vital life-producing currents. 102. 102. The author supports this by explaining that Schenberg disclosed that the ultimate expansion of possible relations to include the whole range of combinations contained in the semitonal scale demands a revaluation of every aspect of musical language. The author further explains that the atonal composercan take nothing for granted and that atonality merely [stipulates] the absence of a priori functional connections among the twelve notes of the semitonal scale. Among these a priori functional connections would be the seven-tone scale, triadic harmonic structure, andkey center the author refers to earlier. 103. 103. The author first states that the diatonic tonal system presupposes the existence of specific properties of that system: a seven-tone scale, triadic harmonic structure, a key center. The author then goes on to state that atonality is defined as merely stipulating the absence of a priori functional connections among the twelve notes of the atonal scale. The purpose of this comparison is then to show how atonality largely resists the limitations of adhering to preconceived concepts of musical organization. 104. 104. This conclusion is implied more than once in the passage. The author states that a composer working within the diatonic tonal system may take for granted the existence of specific properties of that system [such as a seventone scale]. The word choice of take for granted implies that the composer assumes those limitations whereas the atonal system implies that a composer has far more choices: The atonal composercan take nothing for granted except the existence of a given limiting sound world, the semitonal scale. The author alludes to a greater range of choice for the composer later in the passage when discussing how the general composition of an atonal work may vary greatly from one work to the next, even in works by the same composer. 105. 105. The absence of a priori functional connections among the twelve notes of the semitonal scale means that other more readily apparent structures such as triadic harmonic structures will not be available to the listener. The idea that atonal music will have a less readily apparent structure is implied by the statement that the composer is still working under certain constraints such as the existence of a certain limiting sound world, the semitonal scale. 106. 106. The author infers that in the atonal system the ordering is determined more by the composers choices than by the compositional conventions of the diatonic tonal system: An unambiguous ordering is assumed;

133. 133. Even if people drive on different sides of the road in different countries, the central thesis is unchanged by knowing this. The author already gives the example of driving on the left side of the road; therefore, introducing the example of people driving on the right side of the road in another country neither weakens nor lends further support to the central thesis than is already in the passage. At most this new information is simply a variation on the exact same argument. The decision to drive on the right side of the road in a country where it is the law to do so has the same obvious benefits in that country as it does in a country where it is the law to drive on the right side of the road. A responsible individual would obey the law because of these obvious benefits, not because the government mandates driving on the left side, or right side, of the road. 134. 134. The ethnic conflict in Bosnia reflects Gibbons view of history as well as view of human nature that extends from his historical analysis: [Gibbon] instructs us that human nature never changes and that humanitys predilection for factionalism, augmented by environmental and cultural differences, is the determinant of history. 135. 135. According to the author, Gibbon was a conservative along the lines of his contemporary, Edmund Burke, who saw humankinds best hope in moderate politics and flexible institutions that would not become overbearing. The author also observes that a state or an empire can endure only if it generally limits itself to adjudicating disputes among its citizens. The role of the U.S. Constitution, with its checks and balances among the three branches of government, is to limit government in this way.

136. 136. Ethnic diversity, in Gibbons view, is one of the destabilizing factors in human history. Therefore, a stable society that is ethnically diverse would most challenge Gibbons viewhis view might hold up if this society were explained by a system of limited government that adjudicated these ethnic differences. 137. 137. The role of Milan and Nicomedia as functional capitals shows how historical changes occur gradually, because these roles came decades before the formal division of the Empire into western and eastern halves and almost two centuries before Rome officially ceased to be the imperial capital.

145. 145. According to the passage, Sarah was in excellent physical condition prior to her trip to the Caribbean Sea to go skin diving. After her first diving experience, she noticed an elevated pulse rate and ventilation rate. The most likely explanation for her bodys response was the activation of her sympathetic autonomic nervous systemthe fight or flight response caused by adrenaline. 146. 146. According to the passage, Sarah went skiing in the mountains of Colorado. At first, she noticed an elevated pulse rate and ventilation rate. As the week progressed, these rates dropped, but were still higher than usual. This prolonged increase in heart rate and breathing rate was most likely the cause of hypoxia (insufficient oxygen to the body cells) caused by insufficient blood hemoglobin to supply oxygen for exercise at the low oxygen pressure found at high altitudes. 147. 147. According to the passage, Sarah was in excellent physical condition prior to her trip to the Caribbean Sea to go skin diving. After her first diving experience, she noticed an elevated pulse rate and ventilation rate. According to the item, she also noticed that she produced more urine than usual. The increased urine production can be explained by an increased blood pressure caused by adrenaline, released in response to excitement or anxietythe fight or flight response. 148. 148. After Sarahs accident, the physician detected myoglobin in Sarahs urine. Myoglobin is the substance that holds oxygen in the muscles and organs. The physicians observation is consistent with an injury to muscle or organs, but not bone. 149. 149. Control of heart rate, muscle coordination, and appetite is maintained by the brain stem, cerebellum, and hypothalamus, respectively. 150. 150. According to the item, Sarah noticed that her skin blood vessels were usually constricted to conserve body heat in the cold environment of the Colorado mountains where she went skiing. Occasionally, however, her vessels would dilate for short periods of time to enable a sufficient supply of blood (and oxygen) to her cells. Due to the physical exertion of skiing, her cells had an increased need for oxygen. 151. 151. The Cahn-Ingold-Prelog system, susbtituents are listed in order of decreasing atomic number. The atoms directly bonded to the chiral carbon atom (x) are H, C, C, and N. Nitrogen has the highest atomic number and therefore the NHCHO group has the highest priority.

152. 152. The analog of Compound 8 would undergo a Wittig reaction with Ph3P=CH2 to form the double bond in Compound 1. 153. 153. The number of stereoisomers can be calculated using the n formula 2 , where n is the number of stereocenters in the molecule. Compound 1 has 4 stereocenters. 154. 154. The hydrogen on -carbons c and d are most acidic. It can be determined that the hydrogen at carbon c is removed because alkylation occurs at this carbon. 155. 155. The compound contains one ketone group, one ester group, and one carboncarbon double bond. 156. 156. According to the passage, reverse transcriptase uses viral RNA as a template for making viral DNA inside the cell of the host. This process is the reverse of RNA synthesis, a process that normally occurs in the host cell. 157. 157. According to the passage, one method of combating the AIDS virus is to interfere with the binding of the virus to the helper T cell. This is done by producing antibodies to the gp120 proteins on the viral surface. However, the variability of the antibody-evoking region of the gp120 protein makes it difficult for B cells to produce antibodies that neutralize the AIDS virus in the host because antibodies are very specific 158. 158. AZT is effective for treating AIDS because it is missing a hydroxyl group on the 3 carbon, a normal site for the bonding between a phosphate and sugar in the growing DNA polymer. AZT becomes incorporated into the growing DNA chain in place of a regular nucleotide (which would have the hydroxyl group on the 3 carbon), thereby interfering with the process of DNA polymerization. 159. 159. Antibiotics that are effective in interfering with bacterial (but not eukaryotic) ribosomes are ineffective at combating viruses because viruses typically lack ribosomes. Thus, a drug that interferes with ribosome function would have no effect against a virus. 160. 160. According to the passage, during the infection of a helper T cell, gp120 proteins of the viral coat first bind to the CD4 antigens on the cell membrane. Then the viral coat fuses with the membrane, dumping its RNA core into the cell. Once dumped, this RNA core would be transformed into DNA by reverse transcriptase, and the viral DNA would then become incorporated into the host cells chromosomes until activated (replicated) at a later time. Thus, when an AIDS virus has been incorporated into a CD4 cell, but has not yet been replicated,

the viral genetic information is located in the CD4 cells nucleusincorporated into the hosts DNA. 161. 161. The item asks which evolutionary mechanism would most likely explain the presence in humans of CD4 receptors on the helper T cells that bind to the gp120 proteins of the AIDS virus. The most likely scenario is natural selection favoring chance mutation(s) of the virus. This answer is supported by the information in the passage, indicating that there is a high rate of mutation in the gp120 protein of the virus. In addition to having a high rate of mutation, the generation time for a virus is quite short, which enhances the ability of natural selection to make a difference on the viral population, even in a single generation time for humans. 162. 162. The item indicates that there is a virus similar to the AIDS virus, but that this virus infects only B lymphocytes (not the T cells invaded by AIDS virus). The function of a B lymphocyte is to produce and secrete antibodies when it encounters a foreign particle or substance. Thus, a virus that infects only B lymphocytes would be expected to affect the production of antibodies. 163. 163. This reaction is an example of the formation of a hydrazone by the condensation of a hydrazine with an aldehyde. 164. 164. Tertiary alcohols react much more quickly with HCl than do other types of alcohols. 165. 165. The graph shown in the item indicates that the concentration of cyclin rises and falls in a regular manner throughout the cell cycle, reaching a peak just at the beginning of mitosis, gradually declining during mitosis, reaching a minimum at the end of mitosis, and gradually increasing during interphase. The mechanism that can best account for this oscillation in the concentration of cyclin is translation of cyclin mRNA (creating the protein from mRNA template) followed by proteolysis (destruction) of cyclin protein during mitosis. 166. 166. According to the item, embryonic mouse cells divide every 10 hours at 37oC. Under such circumstances, and starting with a single egg, x cells would be present after three days (or 24 x 3=72 hours). The number can be calculated by tracking the doubling time: 1 2 4 8 16 32 64 128 256. At the end of 70 hours (approximately 3 days), there would be 128 cells, assuming that each cell underwent division 10 hours after its previous division.

167. 167. At C-5 the molecule is drawn so that the hydrogen, the group with lowest priority, is pointing away from the viewer. The O has the highest priority, followed by C-4 and then C-6. The groups are oriented in clockwise order of decreasing priority indicating that C-5 has an R-configuration. At C-7 again the molecule is drawn so that the hydrogen is pointing away from the viewer. The O has the highest priority, followed by C-8 and then C-6. The groups are oriented in counterclockwise order of decreasing priority indicating that C-7 has an S-configuration 168. 168. The Grignard reagent will add a methyl group to the ketone generating a tertiary alcohol. 169. 169. The Grignard reagent is CH3MgBr prepared by the reaction of CH3Br with Mg in diethyl ether. 170. 170. The passage states that Compound 5 undergoes a regiospecific Diels-Alder reaction indicating that Compound 6 was added so that the Cl and CN groups are present in the position in the ring as shown in Compound 7, however both stereoisomers of this compound would be present. 171. 171. Step 4 involves the addition of an acetyl group (CH3CO) to Compound 4 which is an acetylation reaction. 172. 172. The passage presents information about inflammatory bowel disease, including Chrons disease and ulcerative colitis, the latter of which is associated with inflammation of the colon. The item asks what process would be most disrupted by an inflammation in the colon. Since the primary process that takes place in the colon is absorption of water, then the absorption of water is the most likely process to be disrupted. 173. 173. The immune system is designed to attack foreign material in the body. It avoids attacking tissues of its own body because it suppresses cells that are specific to its own bodys antigens (surface molecules that would otherwise initiate an immune response).

174. 174. If an ulcer penetrated the walls of the intestine, this would allow the contents of the gastrointestinal tract to enter the peritoneal cavity. Membranes surround this cavity, which would prevent further transport of the gastrointestinal contents through the rest of the body. An ulcer in the small intestine would not allow the contents to enter the lumen because this is the normal place in which the contents are found.

175. 175. Assuming the genetic and autoimmune theories of inflammatory bowel disease are true, then the gastrointestinal antigen being targeted must be located on the surface of proteins encoded by the genes for the disease. Antigens are carried on the surface of cells, not on the chromosomes, DNA segments, or RNA. 176. 176. Inflammatory bowel disease appears to have a genetic component, but it does not show clear evidence of Medelian inheritance. This means that the trait cannot simply be recessive since, if it were, it would show Mendelian inheritance patterns.

177. 177. The passage describes a study in which the blood flow of participants was measured before and after 60 days of exposure to one of four treatments. The treatments included placebo, placebo + vitamin E, fatty acid, and fatty acid + vitamin E. The passage indicates that vitamin E is an antioxidant that reduces in vivo oxidation of ingested fatty acids. As shown in Figure 1, the fatty acid group showed a reduction in blood flow by more than 40%, while the fatty acid + vitamin E showed an increase of about 10%. The most likely explanation for the difference in blood flow between the fatty acid group and the fatty acid + vitamin E group is that the products of fatty acid oxidation (which would be formed when vitamin E is absent) reduce blood flow. 178. 178. One hypothesis suggests that the decrease in blood flow to the skin results from a change in the activity in the sympathetic nerves to the skin. This hypothesis would be supported if researchers observed a change in the norepinephrine content of blood draining from the skin. 179. 179. An alternative method for examining the effects of fatty acids on blood flow would be to measure changes in blood pressure. It blood pressure were measured, one would predict that blood pressure would be lowest in the capillaries, as compared to the heart, arteries, or arterioles. Pressure would be even lower in the veins, but this option was not offered. 180. 180. The passage describes a study in which the blood flow of participants was measured before and after 60 days of exposure to one of four treatmentsafter collecting lifestyle information abut each subject. The treatments included placebo, placebo + vitamin E, fatty acid, and fatty acid + vitamin E. The passage indicates that vitamin E is an antioxidant that reduces in vivo oxidation of ingested fatty acids. To interpret the results of the passage, researchers must assume that subjects do not alter their lifestyle (eg. eating habits) during the course of the experiment.

181. 181. According to the item, the fatty acid used was a 20-carbon polyunsaturated fatty acid. The difference between saturated and unsaturated fatty acids is that saturated fatty acids lack carbon-carbon double bonds (because all carbons are saturated with hydrogen). 182. 182. Researchers collected information about each subjects age, dietary habits, etc. They made sure that skin temperature was constant during the blood flow measurement. The one variable that was not controlled or accounted for was skin blood flow. This was dependent variable. 183. 183. The passage states that alkyl groups bonded to a carbocation center may stabilize the carbocation through hyperconjugation. 184. 184. The proton NMR shows 9 equivalent H and an additional H downfield. This is consistent with the structure of t-butyl alcohol. The 9 hydrogen on the 3 methyl groups are all equivalent. 185. 185. If ethanol was heated with sulfuric acid the oxygen of the ethanol would be protonated in the first step with the alcohol acting as a base accepting a proton from the acid and forming water as a leaving group. 186. 186. The passage states that sec-butyl alcohol is the second most abundant product. The peak in the chromatograph with area of 3 would correspond to the sec-butyl alcohol. The total area is (45 + 3 + 1 + 0.5 + 0.5) = 50. The percentage sec-butyl alcohol would therefore be 3/50 = 6%. 187. 187. All of the products are formed from the quenching of various carbocations, therefore all should have -OH groups. In the infrared spectrum, bands characteristic of -OH groups are found near 3500 cm-1. 188. 188. An organism that causes human disease is isolated and studies. Researchers would conclude that the organism is a bacterium rather than a virus if the organism reproduces in a culture medium lacking host tissue. Bacteria do not require host tissue to reproduce, whereas viruses do. 189. 189. The smooth endoplasmic reticulum most resembles the Golgi apparatus in an intact eukaryotic cell when viewed under the microscope. Both organelles appear to be membranes with many folds.

190. 190. If the ratio of R to R in the product mixture is 2:1, then the starting triglyceride must consist of two R-containing esters and one Rcontaining ester. 191. 191. Lipases catalyze the hydrolysis of fats and other carboxylic esterssimilar to fats, but not fats. Lipases ability to catalyze the hydrolysis of fats and similar molecules reveals that some enzymes interact with several different substrate molecules that have similar chemical linkages. 192. 192. In horses, the genes for red coat color and white coat color are codominant. Heterozygous horses have roan color. If a roan-colored colt (CRCW) has a white mother (CWCW), the fathers coat must be either roan (CRCW) or red (CRCR). The mother could only give the white color gene, so the father must have given the red. For the father to give the red color gene, he would have to carry one or two copies of it, meaning he must be either red or roan, respectively. 193. 193. The passage discusses the connection between H. pylori infection and increased risk of gastric cancer. If H. pylori infection causes increased proliferation of mucosal cells in the stomach, this could lead to gastric cancer if genetic mutations occur in proliferating somatic cells that line the stomach. 194. 194. According to the passage, stomach ulcers and some forms of gastric cancer may be linked to H. pylori infections in the stomach. Without treatment by antibiotics, such infections can be persistent. The most plausible explanation for why host antibodies are ineffective against H. pylori is that antibody proteins may be denatured (destroyed) in the harsh (acidic) environment of the stomach. If the antibody proteins are denatured, they will not function properly. 195. 195. According to the passage, there is more than one strain of H. pylori. One strain expresses the gene vacA that encodes a toxin. The other strain encodes a gene cagA that leads to inflammation and might be related to the genesis of gastric cancer. Thus, a significant difference between the strains is that the strains express different genes.

196. 196. According to the passage, expression of the cagA gene leads to inflammation of the mucosal lining of the stomach. Thus, the cagA gene product triggers the movement of leukocytes into the mucosal tissuebecause leucocytes gravitate toward an inflammation. 197. 197. According to the passage, infection by H. pylori increases ones risk of gastric cancer, but less than 25% of people affected ultimately develop such cancer. Most people affected with H pylori do not develop cancer because they tolerate the infection without developing tumors. The DNA is not damaged and uncontrolled cell division does not occur. 198. 198. According to the passage, infection by H. pylori increases ones risk of gastric cancer, but less than 25% of people affected ultimately develop such cancer. To be most effective, a gene therapy for gastric cancer should be directed against epithelial cells that give rise to tumors. The infection originates in the epithelial tissue, which is the same location of the cancersand the first place to focus preventative measures. 199. 199. Enzymatic activity in the stomach initiates the digestion of proteins. Pepsin is the enzyme, secreted into the stomach, that catalyzes the hydrolysis of proteins into peptides and amino acids. Pepsin works most efficiently at the low pH of the stomacha pH that is obtained by secretion of HCl. 200. 200. According to the passage, the AB cell from the two-cell stage of the nematode, when kept in contact with the P1 cell, goes on to produce neurons, skin, and muscle. In Experiment 1, researchers investigated the role of cell-to-cell communication by separating the cells of a two-cell embryo (AB and P1), and culturing them independently. The cultured AB cells produced neurons and skin, but no muscle, whereas the cultured P1 cells gave rise to all of the tissues produced by P1 cells of an intact embryo. The observation that the fate of an isolated AB cell is different from that of an AB cell in an intact embryo supports the hypothesis that cell-to-cell communication is involved in the determination of cell fate. 201. 201. In Experiment 1, researchers investigated the role of cell-tocell communication by separating the cells of a two-cell embryo (AB and P1), and culturing them independently. The cultured AB cells produced neurons and skin, but no muscle, whereas the cultured P1 cells gave rise to all of the tissues produced by P1 cells of an intact embryo. The results of Experiment 1 indicate that the direction of signaling between the blastomeres of a two-cell embryo is P1 AB (since ABs fate differed when isolated from P1, while P1s fate was the same regardless of whether AB was present or not). 202. 202. In Experiment 2, two-cell embryos were incubated in either cycloheximide (an inhibitor of translation) or actinomycin D (an inhibitor of

transcription). The AB cells were then isolated and washed to remove inhibitors, and grown in culture. AB cells of embryos treated with cycloheximide (the translation inhibitor, which would have prevented production of proteins at the ribosomes of both AB and P1 cells) produced only neurons and skin, while AB cells of embryos treated with actinomycin D (the transcription inhibitor, which would have prevented production of mRNA) produced neurons, skin and muscle their normal fate. These results indicate that the signaling interaction (between P1 and AB cells) at the two-cell stage probably involves protein, since proteins of the P1 cells could not have been produced to carry the necessary message(s) to the AB cells prior to isolation.

203. 203. The results of Experiment 3 support the conclusion that gut specification during the four-cell stage requires cell-to-cell communication between P2 and EMS. As indicated in Figure 2, the only case in which gut differentiation resulted, regardless of how long the cells were left in the four-cell stage, was the combination of EMS and P2 cells. EMS and P2 cells that had zero minutes incubation in the four-cell stage still resulted in gut differentiation. 204. 204. If the zygote contains all unique cell contents that are necessary for gut differentiation, segregation of these substances during cell division would occur in the sequence of zygote to P1 to EMS to E. This information comes directly from the flow chart in Figure 1, which shows that gut cells are derived from the following source: zygote P1 EMS E. 205. 205. According to the information provided, the only somatic or visceral cell-type tissue that derives from a single blastomere is gut. This result is shown in Figure 2, which indicates that after 10 minutes in the four-cell stage, an isolated EMS cell can lead to gut differentiation. In addition to this, the only cases in which gut differentiation occurred were cases in which EMS cells were present. 206. 206. The experiments indicate that nematode cells adopt different fates from those of their neighbors during development by both cell-to-cell signaling and segregation of cytoplasmic contents during cell division. The importance of cell-to-cell signaling is supported by the results of Experiment 1, in which the fate of an AB cell depended on whether it was cultured in the presence of P1 or not. The importance of segregation of cytoplasmic contents during cell division is supported by the results of Experiment 3, in gut differentiation only occurred in cases where an EMS cell was present.

207. 207. The passage shows that Compound 1 undergoes a rearrangement to form a ketone and the double bond in the side chain is retained. If the compound shown in the stem reacts in the same way an aldehyde would form and the double bond in the chain would be retained. 208. 208. A negative entropy of activation indicates that the order of the transition state is increasing. This is true of Chemist 1s mechanism because the molecule would have to achieve the correct conformation for the reaction to take place. 209. 209. The rearrangement shown proceeding by Chemist 1s mechanism can give only one product. If Chemist 2s reaction mechanism were correct there could possibly be cross products. 210. 210. 3500 cm-1. The -OH stretching band appears in the IR at approximately

211. 211. Based on the pedigree shown, the most likely pattern of inheritance for this rare disease (expressed in fewer than 1 in 100,000 people) is sex-linked recessive. The trait must be recessive since it does not appear in the parents generation (the parents are normal), but does appear in several of the children. The trait is most likely sex-linked because only sons are affected, and not just sons from ONE cross, but sons from two crosses. The mother had children with two men, and in both cases half of her sons had the disease. The mother carries the trait XAXa, and passes the trait to half of her sons who inherit a Y from their father, thus leaving them with the disease (Xay). Daughters cannot inherit the disease because the father always gives a normal chromosome (XA). Half the daughters will be entirely unaffected, and half are expected to be carriers like their mother.

212. 212. The gall bladder stores bile produced by the liver and secretes it into the small intestine as needed. Bile acts as an emulsifier, facilitating fat digestion. When the gall bladder is removed, a patient will have reduced ability to digest fats. 213. 213. Unlike other organisms, the liver can partially regenerate after illness or damage. This regeneration is accomplished by mitosis. Mitosis is the process whereby human body cells (not gametes) reproduce. 214. 214. The N-H bond in Compound I would be capable of forming hydrogen bonds with water making it more soluble that the non-polar Compound II.

215. 215. In humans, cholesterol is a precursor to testosterone. Cholesterol and testosterone are only two of several steroid-based natural molecules. The body makes uses of the steroid backbone of cholesterol to produce the hormone testosterone. 216. 216. This item includes a description of an experiment in which actively-dividing, synchronized cells were exposed to radioactively labeled 2deoxythymidine (the nitrogen base incorporated into DNA, but not RNA). After 30 minutes of exposure to the radioactively labeled substance, the cells were rinsed to remove unabsorbed label. At various times thereafter, a group of cells from the culture were examined to determine the quantity of radioactive material in the nuclei. The figure shows a peak in radioactivity between 3 and 13 hours after treatment. This peak represents DNA synthesis, since 2-deoxythymidine is a component of DNA, but not RNA or protein