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The pH scale:
The pH is a way to state hydrogen ion concentration [H + ] .
pH = log
1
= − log H +[ ]
[ ]
H +
[H ] = 1×10
+ − pH
Ex:
The [H + ] of pure water at 25˚C is 1× 10 −7 M. its pH can be calculated as:
[H ] = 1×10
+ −7
, M = 1×10 − pH
∴ pH = 7
The values of pH range from zero for [H + ] =1M( 1×10 0 )
To 14 for [H + ] = 1×10 −14 M.
The pH and [H + ] are inverse of each other.
An acidic solution has a pH values less than 7, and a basic solution has a pH
value more than 7.
A change of one unit in pH from 1 to 2 represents a change of factor of 10 in
[H + ] , a change of 2 units from 1 to 3 represents a 100-fold change in [H + ] .
[H + ] and [OH − ] are related by the ion product constant of water (Kw). If we
know the molar concentration of either [H + ] or [OH − ], we can easily calculate
the other and the same for pH and pOH.
[OH ] = 1×10
− − pOH
[ ] =-
log H +
pH
= - 5.25
= - 6+0.75
[H ]
+
= 5.62X10
-6
Body fluids differ in their acidity stomach acid is the most acidic ( pH=1-3).
Blood plasma is slightly basic (pH = 7.35 – 7.45), if pH changes outside the
range the ability of blood to transport oxygen is reduced. So maintaining the
pH of blood plasma within a narrow range is important to human life. Urine
pH (7- 8.4) is a wide range, it can be acidic, basic or neutral. This is due to the
fact that many acidic and basic substances are removed from the body through
the urine to help maintain the pH of blood plasma.
Measuring pH:
1.the most accurate method of measuring the pH in the laboratory is by a pH
meter.
2. using the indicator. The indicator is an organic compound that changes
color with a pH range, like the litmus. The color of litmus is red at pH < 5
(basic) and blue at pH > 7.8 (alkaline).
Normality :
HCl + NaOH → NaCl + H 2 O
1 mole HCl neutralizes 1 mole NaOH.
H 2 SO 4 + 2 NaOH → Na 2 SO 4 + H 2 O
1 mole H 2 SO4 neutralizes 2 moles so 1mole H 2 SO4 equivalent to 2 moles HCl.
The gram-equivalent weight of an acid is :
The weight of an acid, in grams, that supplies 1 mole of hydrogen ions is
defined as the gram-equivalent weight of that acid.
Also:
The weight of a base, in grams, that supplies 1 mole of OH- or reacts with one
mole of H + is defined as the gram-equivalent weight of that base.
gram.M .wt.of an acid
Gram-equivalent weight of an acid: =
no.of acidic hydrogen per molecule
HCl + H 2O H 3 O + Cl -
NH 3 + H 3O + H 2 O + NH4 +
Certain ions and molecules can be both a Bronsted and a base like in the
ionization of water. One water molecule donates a proton to another molecule
of water to form hydronium ion and a hydroxide ion. One water molecule acrs
as an acid and the other acts as a base:
Conjugate-acid-base pair
NH 3 + H 3O + H 2 O + NH4 +
The stronger the acid, the weaker is its base. The weaker the acid, the stronger
is its conjugate base.
NH 3 + H 2O OH - + NH4 +
The reaction is in equilibrium because the weaker acid and base, ammonia
and water form, so the equilibrium lies to the left.
[H 2 O][CH 3 COOH]
[H 2 O] = is constant
[H O ]= [H ]
3
+ +
K [H 2 O] = Ka =
[H ][CH COO ] (ionization constant for acetic acid)
+
3
−
[CH 3 COOH]
Ex:
Diprotic acids ionize in 2 steps :
H 2 CO 3 + H 3 O + + HCO 3
-
H 2O
Ka=
[H ][HCO ]
+
3
−
[H 2 CO 3 ]
+ H 3 O + + CO 3
- -2
HCO 3 H 2O
[H ][CO ]
+ −2
[HCO ]
3
Ka= −
3
Weak acids have small Ka values and strong acids have large Ka values.
Usually the 2nd Ka value for diprotic acid is smaller than the 1st. and the third
for phosphoric acid is even smaller indicting that the concentration of PO4-3
is very low in an aqueous solution of phosphoric acid (H 3 PO 4 ).
H 3 O + + H 2 PO 4 Ka= 7.52 × 10 −3
-
H 3 PO 4
H 3 O + + HPO 4 Ka= 6.23 ×10 −8
- -2
H 2 PO 4
HPO 4
-2
H 3O + + PO 4
-3
Ka= 2.2 ×10 −13
K=
[NH ][OH ]
4
+ −
[H2O][NH 3 ]
[H2O] =Kb = [NH ][OH ]
+ −
4
[NH 3 ]
Weak bases have small Kb, strong bases have large Kb.
Phosphate ion is a strong base while bicarbonate ion is a weak one.
−2
+ H 2O + OH - K b = 4.52 ×10 −2
-3
PO 4 HPO 4
−
+ H 2O + OH - K b = 1.84 ×10 −4
-2
CO 3 HCO 3
HCO3 + H 2 O H2CO 3 + OH - K b = 2.3 ×10 −8
-
Ka can be expressed as pK b :
pK b = - log K b
Buffer solutions:
A buffer solution is a mixture of either a weak acid + salt of this acid, or a
weak base + a salt of that base.
Such a mixture reacts with both acids and bases so small addition of either
strong acids or bases cause little change in its pH.
Ex:
Mixture of equimolar quantities of acetic acid and solution acetate dissolved
in water is a buffer solution.
If small amounts of a strong acid added to the buffer it will react with the
conjugate base (acetate):
H 3O + + C 2 H 3O 2 C 2 H 3O 2 H + H 2O
-
HPO4 -2 + OH - HPO4 -2 + H 2 O
Another conjugate acid-base pair that acts as a buffer is carbonic acid-
bicarbonate ion.
Carbonic acid (H 2 CO 3 ) is formed by dissolving CO 2 in body fluids.
CO 2 + H 2 O + H 2O
-
H 2 CO 3 HCO 3
Normally in body fluids as blood there is 24 mEq./L of bicarbonate ion : 1.2
mEq./L of carbonic acid. The pH of blood 7.35- 7.45 when this ration is
maintained (20:1) .
The pH of blood becomes acidic when
[HCO ] 〈 20 .
3
-
[H 2 CO 3 ] 1
The acidic condition of blood signified by a pH. Less than 7.35 is called
acidemia.
The pH of blood becomes more basic when the ratio.
[HCO ]/[H CO ] 〈 20 / 1.
3
-
2 3