MODULE 19 PATHOBIOLOGY MODULE (PATHOLOGY)

PRACTICAL PATHOLOGY 1 LYMPH NODES AND CNS DISORDER

1. Jars

Organ: Slice of brain Description: The brain shows Cystic areas surrounded and traversed by glial tissue that give it honeycomb appearance. Diagnosis: Healed brain infarct.

ACE 2013/14

MODULE 19 PATHOBIOLOGY MODULE (PATHOLOGY)

Organ : Two hemispheres of the brain Description: The right hemispheres is distorted by massive area of haemorrhage which is: In the lateral ventricle Dark brown in colour Diagnosis: Intracerebral haemorrhage.

ACE 2013/14

MODULE 19 PATHOBIOLOGY MODULE (PATHOLOGY)

Organ: Two hemispheres of the brain Description: The cerebrum is infiltrated in one area by a tumour mass, which is: Ill defined Infiltrating the surrounding brain tissue Greyish white in colour with areas of hemorrhage and necrosis Diagnosis: Glioblastoma multiforme.

ACE 2013/14

MODULE 19 PATHOBIOLOGY MODULE (PATHOLOGY)

Organ: Spleen Description: Part of a moderately enlarged spleen Firm rubbery in consistency The external surface is smooth Cut surface: o Mottled by translucent light brown areas of amyloid material seen against a red background of splenic tissue Diagnosis: Amyloid (sago) spleen.

ACE 2013/14

MODULE 19 PATHOBIOLOGY MODULE (PATHOLOGY)

Organ: Spleen Description: Spleen is slightly enlarged The cut section is studded whith numerous tubercles distributed all over the spleen, but more condensed near the periphery. Tubercles are rounded, soft in consistency, showing central yellow cheesy necrotic tissue. Diagnosis: Miliary tuberculosis-spleen.

ACE 2013/14

MODULE 19 PATHOBIOLOGY MODULE (PATHOLOGY)

Organ: Spleen Description: An enlarged spleen The cut section shows a large well-circumscribed grayish white well defined non-encapsulated tumour formed of multiple coalescent nodules. The tumour shows foci of necrosis. Diagnosis: lymphoma of the spleen.

ACE 2013/14

MODULE 19 PATHOBIOLOGY MODULE (PATHOLOGY)

Organ: Lymph nodes. Description: A group of lymph nodes that are enlarged and matted together. Cut surface: o Shows numerous areas of yellowish cheese like necrotic tissue. Diagnosis: Tuberculous lymphadenitis.

ACE 2013/14

MODULE 19 PATHOBIOLOGY MODULE (PATHOLOGY)

Organ: Lymph nodes Description: A group of lymph nodes that are enlarged , firm, and discrete. Lymph nodes are variable in size and have a smooth surface. Cut surface o Tan-coloured with foci of necrosis. Diagnosis: Hodgkins lymphoma.

ACE 2013/14

MODULE 19 PATHOBIOLOGY MODULE (PATHOLOGY)

2. HISTOPATHOLOGY

ACE 2013/14

MODULE 19 PATHOBIOLOGY MODULE (PATHOLOGY)

Diffuse Non-Hodgkins Lymphoma, LN Section revealed lymph node showing Loss of normal architecture. Infiltration by diffuse sheets of monotonous large lymphomatous cells showing large vesicular nuclei within scant indistinct cytoplasm. Mitotic figures are detected.

ACE 2013/14

MODULE 19 PATHOBIOLOGY MODULE (PATHOLOGY)

Chronic venous congestion, Spleen. Splenic tissue showing: The Malpighian bodies (white pulp) are atrophic The venous sinuses (red pulp) are dilated and show marked congestion. Focal areas of fibrosis, haemorrhage and hemosiderin pigmentation are seen (fibrosiderotic nodules of Gamna Gandy bodies)

ACE 2013/14

MODULE 19 PATHOBIOLOGY MODULE (PATHOLOGY)

Adenocarcinoma metastases, Lymph node The lymph node is infiltrated by carninomatous cells The tumor cells are arranged in acini of variable sizes and shapes. These cells showing larged hyperchromatic nuclei within scant cytoplasm. Mitotic figures are detected.

ACE 2013/14