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A FIELD REPORT
BY
LWASAMPIJJA BAKER
bubakes2000@gmail.com
MARCH 2OO8
PHARMACEUTICAL INDUSTRIAL REPORT ON
PRODUCTION OF EYE DROPS AT MENGO HOSPITAL,
DEPARTMENT OF PHARMACY
A FIELD REPORT
BY
LWASAMPIJJA BAKER
……………………………………………………
MARCH, 2OO8
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ACKNOWLEDGEMENTS
My most sincere thanks go to my field supervisor Mrs. Freda Mutalya for the great work
Mr.Godfrey Mubuuku, Mr. Andrew Kibumba, Alex Muhumuza and Mrs. Phoebe Babirye
I also like to thank my Principal Tutor Mr. Ojaki Mikloth for laboring and make
arrangements and book our stay in this unit. May God bless you.
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TABLE OF CONTENTS
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INTRODUCTION
1.1 BACKGROUND
The curriculum of the Pharmacy school indicate clearly that before the end of the course
an industrial exposure must be under taken by every one going through out the training.
This time around, the industrial attachment was conducted at Mengo Hospital Eye Drops
production unit for a period of two three week in the month of March 2008.
Division. The hospital has many departments among which the is eye drop production
unit was initialize by the Christoffel blinden Mission (CBM) a German based
Organization. It’s the above that further established prior to Eye clinic and set the eye
drop production unit so as to cater for the medications that related to the eye conditions
The Christoffel blinden Mission based on small scale production initially but this has
grown tremendously and now there is production close to three batches i.e. 1500 eye
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1.2 OBJECTIVES
2) To carry out exercise on the theoretical knowledge obtained during class lectures.
The exercise served a purpose of providing more experience in the manufacturing of Eye
drops serves to equip me with the necessary knowledge, skills and attitudes relating to
manufacturing of Eye drops. The information obtained helped to familiarize me with the
condition and equipment including the procedures involved with Eye drops.
The Field work was conducted between the 10th March, 2008 to the 24th March, 2008 at
1.5.1 Premises:
The eye production unit premise is attached to the major pharmacy department and is
production is done and kept. Also transactions with clients are made here.
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• Washing room: This is where was of bottles and some equipment is carried out.
• Changing Room: This where full protective gears (Gowns, boots, masks, head
caps, gloves) are kept. The dressing process of personnel prior to entering the
1.5.2 Equipment:
c) Distiller
d) Steller Hand Press: For sealing the bottles with the steller caps and
pipettes.
f) Bottle openers: These are used for uncapping the already used bottles.
products.
- Funnel: This leads the fluid from the main the main filter.
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- Pressure Gauge and Pump: Increases pressure so as to quicken the filtration
process
- Tanks (Jerricans)
j) Glassware: This includes the beaker, measuring cylinder and the bottles
xi. Computer: This is for designing labels and entry/storage of data concerning
These involve:
Already used bottles (vials) are collected and sorted so as to obtain consistent size bottles
that suite the volumes to be packed and are then soaked to ease the removal of the label
and washing.
Removal of the bottle caps (tops) follows, the uncapped bottles are thoroughly washed
and rinsed with cleaned distilled water and then sterilized by autoclaving t 134°C for 3
minutes.
Imported steller caps and pipettes are washed and rinsed with freshly prepared and cooled
distilled water and kept in a sterile condition, the same applies to the sterilized bottles.
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2) Decontamination of the production room.
The room swept, dusted and thoroughly cleaned using jik (Sodium Hypochlorite) and
omo detergents. The room is then dried using a mop. This room is kept closed and the air
Product quantities to be prepared are determined and basing on the manual for eye drop
production (WHO Script and CBM) the respective amounts of ingredients to be used in
The personnel to carry out the production process enter the dressing room. In there
sterile; Gowns, gloves, head gear, masks and boots, specifically used in the production
The well dressed personnel enter the production room next to the changing room
balance.
water.
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♦ The dispensing device under the operation of personnel dispenses a pre-
who cap the steller caps and pipettes onto bottles using a Hand press
steller.
The above process is continued until all the preparation has been packed in the respective
6) Sterilization.
The sealed bottles containing the preparation are packed in grid baskets (maximum of
1500 bottles) which are then placed in the autoclave. The autoclave is closed and set at a
temperature of 121°C and the duration interval of 15 minutes is entered. The autoclave is
turned on to start the sterilization and once the alarm sound is heard, then its turned off
because the sterilization process is over. The pressure is allowed to drop to atmospheric
pressure and then the autoclave is opened and the product allowed to cool.
7) Screening.
The bottles containing the sterilized preparation are held against theLV28 Liquid
8) Labelling.
The sterilized products that have passed the screening test are labeled appropriately
9) Storage
The well labeled preparations are stored in suitable conditions awaiting dispensation to
the clients.
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1.7 LESSONS LEARNT, CHALLENGES, CONCLUSION AND
RECOMMENDATIONS.
- Equipment like, dispenser head, filtration apparatus, electronic balance, the semi-
1.7.2 Challenges:
- The capacity of the equipment, staff, and structural facility does not meet the high
- The time of practice was limited (three weeks) and it wasn’t enough to grasp with
1.7.3 Conclusions:
- Knowledge and practical skills on the production of eye drops were attained.
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1.7.4 Recommendation:
- The unit should by a paper cutting equipment to ease and shorten the time of
cutting labels.
- The field work time should be made long in order to achieve the objectives of the
exercise.
- The facility should think about employing more Pharmacy Technicians to avoid
- The unit should take up a policy of that encourages students to come and
-The end -