Beruflich Dokumente
Kultur Dokumente
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Definitions
Enteral Of or relating to the intestines (e.g. by mouth, orally, per tube) Parenteral Introduced other than by way of the intestines ( (e.g. i t intravenous, i t intramuscular, l subcutaneous) b t ) Aseptic Technique The technique for manipulations of compounded sterile products and parenteral preparations that prevents contamination
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Definitions (cont.)
Contamination any effect or action that has a negative impact on a product's integrity making it unfit for use Chemical composition pH Sterility (e.g. microorganism contamination) Pyrogenicity y g y Biological or therapeutic potency Physical appearance Particulate matter (e.g. dust, glass or precipitation)
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Background g
Sources of p product contamination People (most common) Touch contamination Generation of particulates from shedding cells or hair Supply air Heating Ventilation and Air Conditioning C ( (HVAC) C) Infiltration Particles from adjacent spaces Internal generation Walls, floors, ceilings, packaging, equipment
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Only products essential to product preparation should be placed in the laminar flow hood to minimize the potential for contamination
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The killing killing power power of steam is due to its latent heat of vaporization 80 calories: 1 L water to boiling g 540 calories: 1 L boiling water to steam
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Action of Steam
Steam contacts a cooler surface, surface condenses, causing a huge decrease in volume and setting g up p a negative g pressure that draws more steam Condensation occurs as long g as there is a temperature differential Action of steam ensures: Surface heating, penetration, and protein coagulation
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Time ( (min) ) 15 30 30
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Special Situations
Media boils out of bottles differs among media Very dense or closed dry objects beaker full of microfuge tubes with aluminum foil covering
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TERIMA KASIH
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