Beruflich Dokumente
Kultur Dokumente
Harold S Nelson, MD Professor of Medicine National Jewish Health, and University of Colorado School of Medicine Denver, Colorado, USA
From 3 Canadian databases information obtained on 1274 pregnancies in asthmatic women. Distribution of asthma severities and incidence of small for gestational age babies were: Prevalence SGA - mild 82.6% 13.8% 17.4% Sig - moderate 12.4% - severe 5.0%. 19.5% Sig
Dombrowski MP. Obstet Gynecol 2006;108:667-81 Killien & Olausson AJOG 2006;194:480-5
Maternal Vitamin D intake During Pregnancy is Inversely Associated with Asthma and Allergic Rhinitis in 5-yearold Children.
M Erkkola, et al. Clin Exp Allergy 2009;39:875-82
Finnish birth cohort (n = 1669). - Food frequency questionnaire during pregnancy - Children assessed at age 5-years. Maternal intake of vitamin D in food negatively associated with risk in offspring of: - Asthma (HR 0.80) - Allergic rhinitis (HR 0.85)
Household Chemicals, Persistent Wheezing, and Lung Function: Effect Modification by Atopy?
J Henderson, et al. Eur Respir J 2008;31:547-54
Objective: Assess the effects of maternal use of domestic chemicals during pregnancy on wheezing and lung function in children age up to 8.5 years. Maternal composite household chemical exposure score (CHCE) derived during pregnancy.
Household Chemicals, Persistent Wheezing, and Lung Function: Effect Modification by Atopy?
CHCE score was associated with: - Early (< 18 months) and Intermediate (1836 months) persistent and Late (>30 month) wheezing in non-atopic children. - Decrements in FEV1 and FEF25-75%. Effects may result from prenatal development effects or post-natal irritant effects.
J Henderson, et al. Eur Respir J 2008;31:547-54
Never wheeze
0.0 J Henderson, et al. 1.0
Non-Atopic
Prospective study (1990-6) of 48,028 nurses, mean age 57 years. > 14 days/month versus no use associated with OR 1.62 for development of physician diagnosed asthma
Prenatal Acetaminophen Exposure and Risk of Wheeze at Age 5 years in an Urban, Low-Income Cohort
M Perzanowski, et al. thorax 2009
Prenatal acetaminophen use predicted wheezing and atopy at age 5-years in a minority, New York cohort (n = 301) none 1d 2-4d 5d p wheezing 1.0 1.06 1.95 2.26 <.001 Seroatopy1.0 1.21 1.32 1.99 <.001
Prenatal Acetaminophen Exposure and Risk of Wheeze at Age 5 years According to Glutathione S Transferase Polymorphism The association of prenatal acetaminophen exposure and current wheezing (OR 2.08) & atopy (OR 1.96) at age 5 years was limited to children with GSTP1 AG or GG alleles. GSTT1 (present vs.. null) associated with seroatopy (p < 0.001)
M Perzanowski, et al. thorax 2009
Association Between Acetaminophen Use, Wheezing age 5 years, and GSTP1 Polymorphisms
GSTP1-01 AA(31%), Trend P=0.65
70%
GSTP1-01 AG/GG (68%), Trend P<0.001
None
2-4
> _5