GNIPST BULLETIN 2013

1118-1177-4796-9849-7562-5062

TO GROW AS A CENTRE OF EXCELLENCE IN THE FIELD OF PHARMACEUTICAL AND BIOLOGICAL SCIENCE

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5th July, 2013

Volume No.: 26

Issue No.: 04

Vision

Contents

Message from GNIPST Letter to the Editor News Update Health awareness Disease Outbreak News Forth Coming Events Drugs Update GNIPST Photo Gallery
For your comments/contributionOR For Back-Issues, mailto:gnipstbulletin@gmail.com

Campus News Students Section Editors Note Archive

1 EDITOR: Soumya Bhattacharya

GURU NANAK INSTITUTE OF PHARMACEUTICAL SCIENCE AND TECHNOLOGY

05-07-2013

MESSAGE FROM GNIPST

GNIPST BULLETIN is the official publication of Guru Nanak Institute of Pharmaceutical Science & Technology. All the members of GNIPST are proud to publish the 26th Volume of GNIPST BULLETIN. Over the last two years this bulletin updating readers with different scientific, cultural or sports activities of this prestigious institute and promoting knowledge of recent development in Pharmaceutical and Biological Sciences. Students section is informing readers about some curious facts of drug discovery, science, sports and other relevant fields. We look forward to seeing your submission and welcome comments and ideas you may have.

LETTER TO THE EDITOR.

NEWS UPDATE

Novel strategies for making long-term antibiotic use safer (3rd

July, 2013)

A team of scientists at the Wyss Institute for Biologically Inspired Engineering at Harvard University has discovered why long-term treatment with many common antibiotics can cause harmful side effects and they have uncovered two easy strategies that could help prevent these dangerous responses. They suspected that clinical levels of antibiotics can cause oxidative stress that can lead to damage to DNA, proteins and lipids in human cells, but this effect can be alleviated by antioxidants. Read more

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Smart Anticancer 'Nanofiber Mesh'

(3rd July, 2013)

A MANA research team has developed a new nanofiber mesh which is capable of simultaneously realizing thermotherapy (hyperthermia) and chemotherapy (treatment with anticancer drugs) of tumors. They succeeded in efficiently inducing natural death (apoptosis) of epithelial cancer cells. Read more

Novel Chemistry for New Class of Antibiotic

July, 2013)

(3rd

University of Adelaide research has produced a potential new antibiotic which could help in the battle against bacterial resistance to antibiotics. The compound is a protein inhibitor which binds to the enzyme (called biotin protein ligase), stopping its action and interrupting the life cycle of the bacteria. Read more

Exercise reorganizes the brain to be more resilient to stress (3rd July, 2013)
According to a research team based at Princeton University, Physical activity reorganizes the brain so that its response to stress is reduced and anxiety is less likely to interfere with normal brain function.The researchers report in the Journal of Neuroscience that when mice allowed to exercise regularly experienced a stressor exposure to cold water their brains exhibited a spike in the activity of neurons that shut off excitement in the ventral hippocampus, a brain region shown to regulate anxiety. Read more

Molecular switch that kick starts formation of arteries identified (3rd July, 2013)
Researchers in the laboratory of Gladstone describe the precise order and timing of signals that spur the formation of arteries. Specifically,
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they piece together a molecular signaling pathway by which a protein called vascular endothelial growth factor (Vegf) directs the activation of Delta-like 4 (Dll4), which is critical to artery formation. Read more

Scientists Identify Genetic Cause of 'Spongy' Skin Condition (3rd July, 2013)
Scientists have identified the genetic cause of a rare skin condition that causes the hands and feet to turn white and spongy when exposed to water. Read more

DNA Markers in Low-IQ Autism Suggest Heredity

(3rd July, 2013)

The research team led by Eric Morrow in the Department of Molecular Biology, Cell Biology, and Biochemistry at Brown University, made its findings by analyzing the DNA of more than 2,100 children with autism who were born into "simplex" families where neither their parents nor a sibling has an autism disorder a Simons Foundation data set known as the Simons Simplex Collection. The researchers combed through the genomes of affected children and their siblings for so-called "runs of homozygosity" long strands of DNA in which the genetic material contributed by both the mother and the father turn out to be the same. Read more

New

Mechanism

for

Human

Gene

Expression

Discovered (3rd July, 2013)

University of Chicago researchers have found a single gene that encodes two separate proteins from the same sequence of messenger RNA. This is the first example of a mechanism in a higher organism in
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which one gene creates two proteins from the same mRNA transcript, simultaneously. Read more

HEALTH AWARENESS

Lifestyle Modifications in Diabetic World -Dipanjan Majumdar

Diabetes or Diabetes mellitus or Madhumeha, as it is referred in Ayurveda, is a collective term for a heterogeneous group of disorders characterized by abnormal secretion of insulin and/or insensitivity of insulin receptors. The two major forms of diabetes are type 1 (previously called insulin-dependent diabetes mellitus, IDDM, or juvenile-onset diabetes) and type 2 (previously called noninsulindependent diabetes mellitus, NIDDM, or maturity-onset diabetes). Type 2 diabetes is the most common form of diabetes, accounting for 90 - 95% of cases. In type 2 diabetes, the body does not respond properly to insulin, a condition known as insulin resistance. Lifestyle and Diabetes Life style and food habits play major causative role in patients suffering from Type 2 Diabetes. Effect of Alcohol and Smoking: Drinking a moderate amount of alcohol with food does not affect blood sugar levels significantly but mixers, such as fruit juice or regular cola, can increase blood sugar levels and increase the number of calories consumed in a day. Also, calories from alcohol have little nutritional value and may interfere with efforts to lose weight or contribute to weight gain.

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Over 25 percent of people newly diagnosed with diabetes are smokers. Quitting smoking is one of the most important things a patient can do to improve their health. Smokers with diabetes have an increased risk of death (especially from heart attacks and strokes), high LDL cholesterol levels, worsened blood sugar controlled, nerve damage from diabetes, kidney disease leading to dialysis, foot ulcer and amputation of toes, feet or legs caused by peripheral vascular disease. Exercise and Diabetes For diabetics, exercise promotes cardiovascular fitness and weight loss, lowers high blood pressure, improves lipid profiles, improves blood sugar control in some cases, and leads to an overall sense of well-being. When combined with dietary lifestyle intervention it can even help prevent type 2 diabetes in some people. People with diabetes who want to start an exercise program should consult with their healthcare provider first. Generally a physical examination and a resting electrocardiogram (ECG) is done in sedentary adults (age >50 years) with diabetes prior to beginning an exercise program. It is best to begin a gentle exercise program and to gradually progress to a more vigorous program as tolerated. Gentle aerobic exercises, which increase the heart rate for a sustained period of time, are often the best choice for diabetics. A reasonable exercise session consists of 10 minutes of stretching and warm-up, followed by 20 minutes of gentle aerobic exercise. Examples of aerobic exercise include walking, cycling, swimming, or rowing. Diabetics with well-controlled blood sugar levels and no complications can usually participate in most any type of exercise. Exercise does not have to be intense to be beneficial. Persons who want to increase the intensity of exercise should do so gradually, and
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should stop if he or she experiences worrisome symptoms, such as chest discomfort or nausea. People with diabetic eye complications (proliferative retinopathy) may be advised to avoid high-impact activities and strenuous weightlifting, which can increase blood pressure and cause bleeding in the eye. People with neurologic complications (peripheral neuropathy) are usually advised to avoid traumatic weight-bearing exercises such as running, which can lead to foot ulcers and stress fractures although this depends on the severity of the nerve damage. Most of the benefits of exercise for people with diabetes require a regular, long-term exercise program. Patients should commit to exercising 30 minutes a day most days of the week. People who take insulin should try to exercise at the same time of the day. This practice can help to maintain predictable blood sugar levels. Diabetics who use insulin should : Measure blood sugar before, during, and after exercise to determine their body's typical response to exercise. If the pre-exercise blood sugar reading is 250 mg/dL (13.9 mmol/L) or higher, exercise should be postponed until the level is under control. Consider a decrease in insulin dose by about 30 percent during exercise. Choose an insulin injection site away from exercising muscles (for example, avoid the legs if running). Keep rapidly absorbed carbohydrates on hand (glucose tablets, hard candies, or juice). Eat a snack 15 to 30 minutes before exercise, and again every 30 minutes during exercise.

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Eat a source of slowly absorbed carbohydrates (dried fruit, fruit jerky, granola bars, or trail mix) immediately after exercise. This will counter a post-exercise drop in blood sugar levels.

DISEASE OUTBREAK NEWS

Human infection with avian influenza A(H7N9) virus

(4th

July, 2013)

The National Health and Family Planning Commission, China notified WHO of an additional retrospectively detected laboratoryconfirmed case of human infection with avian influenza A(H7N9) virus. Read more

FORTHCOMING EVENTS

The 2nd Pharm. Tech IAPST International Conference on "New insights into
diseases and recent therapeutic approaches" from 17th to 19th January 2014 in Kolkata, India. Read more

DRUGS UPDATES

FDA approves the first non-hormonal treatment for hot flashes associated with menopause (28th June)
The U.S. Food and Drug Administration approved Brisdelle (paroxetine) to treat moderate to severe hot flashes (vasomotor symptoms) associated with menopause. Brisdelle, which contains the
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selective serotonin reuptake inhibitor paroxetine mesylate, is currently the only non-hormonal treatment for hot flashes approved by the FDA. Read more

CAMPUS NEWS A one day seminar cum teachers development programme for school
teachers on the theme of Recent Trends of Life Sciences in Higher Education organized by GNIPST held on 29th June, 2013 at GNIPST auditorium. The programme was inaugurated by Prof . Asit Guha, Director of JIS Group, Mr. U.S. Mukherjee, Dy Director of JIS Group and Dr. Abhijit Sengupta, Director cum Principal of GNIPST with lamp lighting. The programme started with an opening song performed by the B.Pharm students of this institute. The seminar consists of a series of lectures, video presentations and poster session. On the pre lunch session 4 lectures were given by Dr. Lopamudra Dutta, Debabrata Ghosh Dastidar, Swati Nandy and Tamalika Chakraborty. On their presentation the speakers enlighten the recent development of Pharmacy, Genetics and Microbiology and their correlation with Life Sciences. On the post lunch session, Saini Setua and Sanchari Bhattacharjee explained the recent development and career opportunities in Biotechnology and Hospital Management. The programme was concluded with valedictory session and certificate distribution. About 50 Higher secondary school teachers from different schools of Kolkata and North& South 24 Parganas district of West Bengal participated in this programme. A good interactive session between participants and speakers was observed in the seminar. The seminar
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was a great success with the effort of faculties, staffs and students of our Institute. It was a unique discussion platform for school teachers and professional of the emerging and newer branches of Life Science. JOB OPPOURTUNITY There are some job opportunities in Cadell Pharmaceuticals, Kolkata in the Production unit . The interested B.Pharm. pass out students are requested to contact Mr. Anshuman Bhattacharya (9836070711) immediately.

The following B.Pharm. final year students have qualified, GPAT2013. We congratulate them all.

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G GN NI IP PS ST T iis sn no ow wa ap pp pr ro ov ve ed db by yA AI IC CT TE Ea an nd da af ff fiilliia atte ed d tto oW WB BU UT Tf fo or r

c co on nd du uc cttiin ng g tth he e ttw wo o y ye ea ar rs s p po os stt g gr ra ad du ua atte e c co ou ur rs se e ( (M M..P Ph ha ar rm m) ) iin n P PH HA AR RM MA AC CE EU UT TI IC CS S.. T Th he ea ap pp pr ro ov ve ed dn nu um mb be er ro of fs se ea att iis s1 18 8..

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STUDENTS SECTION
WHO CAN ANS WER FIRS T????

Which

Indian

entrepreneur

established

Standard Organics Limited in 1980? Which medicinal plant is also known as lucky nut?
Answer of Previous Issue Question:

A) Heroin B) Tetrahydrocannabinol

Send your thoughts/ Quiz/Puzzles/games/writeups or any other contributions for Students

Section& answers of this Section atgnipstbulletin@gmail.com EDITORS NOTE I am proud to publish the 4th issue of 26th Volume of GNIPST BULLETIN. GNIPST BULLETIN now connected globally through facebook account GNIPST bulletin I want to convey my thanks to all the GNIPST members and the readers for their valuable comments, encouragement& supports. I am thankful to Dr. Abhijit Sengupta, Director of GNIPST and Prof. Dipankar Chakraborty, Registrar of GNIPST for their valuable advice and encouragement. Special thanks to Dr. Prerona Saha and Mr. Debabrata Ghosh Dastidar for their kind co-operation and technical supports. I am also thankful to Mr. Dipanjan
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Majumdar, Asst. Professor, GNIPST for his contribution to this issues Health Awareness section. An important part of the improvement of the bulletin is the contribution of the readers. You are invited to send in your write ups, notes, critiques or any kind of contribution for the forthcoming special and regular issue.

ARCHIVE The general body meeting of APTI, Bengal Branch has been conducted at GNIPST on 15th June, 2012. The program started with a nice presentation by Dr. Pulok Kr. Mukherjee, School of Natural Products, JU on the skill to write a good manuscript for publication in impact journals. It was followed by nearly two hour long discussion among more than thirty participants on different aspects of pharmacy education. Five nonmember participants applied for membership on that very day. GNIPST is now approved by AICTE and affiliated to WBUT for conducting the two years post graduate course (M.Pharm) in PHARMACOLOGY. The approved number of seat is 18. The number of seats in B.Pharm. has been increased from 60 to 120. 2nd World Congress on Ga-68 (Generators and Novel Radiopharmaceuticals), Molecular Imaging (PET/CT), Targeted Radionuclide Therapy, and Dosimetry (SWC-2013) : On the Way to Personalized Medicine Dates 28 Feb 2013 02 Mar 2013 Location: Chandigarh, India.Details.

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AICTE has sanctioned a release of grant under Research Promotion Scheme (RPS) during the financial year 2012-13to GNIPST as per the details below: a. Beneficiary Institution: Guru Nanak Institution of Pharmaceutical Science & Technology. b. Principal Investigator: Dr. Lopamudra Dutta. c. Grant-in-aid sanctioned :Rs. 16,25000/- only d. Approved duration: 3 years e. Title of the project: Screening and identification of potential medicinal plant of Purulia& Bankura districts of West Bengal with respect to diseases such as diabetes, rheumatism, Jaundice, hypertension and developing biotechnological tools for enhancing bioactive molecules in these plants.

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