Main Idea: The author proposed nonlinear analysis for characterizing cardiac and non-cardiac diseases of the Autonomic

Nervous System based on Heart Rate Variability (HRV). Three nonlinear HRV parameters are considered: 1) Approximate Entropy (ApEn); 2) Sample Entropy (SampEn); 3) Symbolic Entropy (SE). Major Issues: 1. The motivation of this thesis is not clearly stated in this section. It would be better if the author describe clearly what the contribution of this thesis is and relate it to the problem definition. For example: What the contribution really is? What you have been observed? Whats the reason behind this idea? 2. In related to the point number 1, the author need to evaluate the performance comparison and explanation of each nonlinear techniques. For example, in what cases that the ApEn is given more precise results compared to the SampEn or other nonlinear method. 3. The problem definition of this thesis was not clearly described. For example, what is the existed problems for characterizing the cardiac and non-cardiac diseases? Whats the current methodology for characterizing the subjects that are suffering from Cardiac and non-cardiac diseases? 4. The objectives of this thesis are not fulfilled. For example: Derive the power spectral density distribution. In the discussion part, the author did not offer a balanced discussion how the author derive the Power Spectral Density distribution and the Spectral Entropy using HRV. There is no any explanation about it. 5. In related to point number 4, in this thesis, the author does not offer a discussion of values/parameters that are used for the analysis (i.e., chapter IVImplementation of ApEn and SampEn). There is no discussion why and how the author uses those values for algorithm implementation. A comparison of different values/parameters could be made to see the optimal solution for characterizing different cardiac and non-cardiac diseases of Autonomic Nervous system. Moreover, the author does not explain the details of how the author did the analysis of FFT and Autoregressive model to analyze power spectral. For example, how the author determines the values/parameters for the modeling. The same issues also applied for the derivation of Correlation Dimension. 6. The consistency of each chapter should be carefully noted. For example: the author stated that no studies have been addressed the problem of detecting the impact of Thyroid on ANS and impact of Depression on ANS. It contradicted because most of the algorithm implementations used in this thesis are based on the previous work. (e.g., 101, 102, 105, etc]. Minor: Chapter III

1. Section 3.3.3 page 40, second paragraph. It would be better if the author put the citation. 2. Correction need in page 38 (3.9) Chapter VII Instead of only discussing the results, it is also important to discuss which nonlinear algorithm is the best to detect more accurate for the specific diseases (e.g., CHF, AF, Depression, etc).