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Elizabeth D.

Neil

Specific and Non-Specific Resistance to Disease


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Down 1. Learned 2. Part of the 1st line of defense; a fluid that lubricates & moistens the cavity surface; it traps microbes and foreign substances; it contains microbial properties to filter, moisturize, and warms air 3. Coordinate activity of the immune response; cytokines are secreted to stimulate the non-specific immune response to continue, strengthen and boost appropriate specific responses (2 words) 5. Are mediated by cells not by antibodies; there are different types with different antigens on their surfaces and have different roles in the immune response; cells mature in the thymus (2 words) 7. Occurs during the activation of T cells because they require two signals to become fully activated - an antigen-specific and antigen nonspecific 8. Remembers the previous antigen so a second encounter prompts an even more rapid and vigorous response; long-term-stable cells that can differentiate into plasma cells (2 words) 10. A defense mechanism that uses at least 30 proteins in the blood that helps antibodies kill the invaders (2 words) 11. An essential part in the defense against microbes; are involved early in nonspecific defense responses (2 words) 12. Defenses, that are not specific to individual pathogens (2 words) 13. Produce antibodies; that is, they do not mature in the thymus

14. Highly focused identification of a foreign molecule then seek it out all over the body to attack on a particular antigen (2 words) 15. Deal with antigens that have gotten through the initial defenses and still remain a threat to the infected organism; involves chemical and cellular defenses (4 words) 16. Usually has direct contact with the external environment (4 words) 18. Immune cells that never forget (2 words) 20. Genetic 21. 2nd Responders; they are very large phagocytes that are slow and powerful; they reach out & grab bacterium and pull it into the vesicle; are a vital link between the non-specific & specific defenses Across 1. These are usually proteins, usually associated with the surface of a foreign object, sets off a defense reaction; Epitopes are part of these 4. First recognize that other body cells are infected; then kills those cells therefore kills cell AND the infection (3 words) 6. Cells that can IMMEDIATELY produce (and secrete) antibody molecules (2 words) 9. All mucous secreting cells lining all openings into the body (2 words) 14. A biological barrier protecting the internal environment 17. Destroys its own cells that have been infected by viruses, or that have become cancerous (3 words) 19. This is what you are born with (2 words) 22. They must recognize (2 words)

1st Line of Defense 2nd Line of Defense Acquired Antigen Dependent Antigen Independent F. Antigens A. B. C. D. E.

G. H.

B-Lymphocytes Complement System I. Co-Stimulation J. Cytotoxic Killer Ts K. Helper T-Cells L. Innate

M. N. O. P. Q.

Macrophages Memory B-Cells Mucous Mucous Epithelium Non Specific Defense R. Phagocytic Cells

S. T. U. V. W.

Plasma B-Cells Skin Specific Resistance T-Cell Receptors T-Lymphocytes

Specific and Non-Specific Resistance to Disease


Answer Key
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A C
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M U 4 C O U S

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U Y T O T O X I R E D C K I L L

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E L
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T -

P E R

L Y M

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C O
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M E
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C O

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P P
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H O C Y T E S

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N 0
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S A T I M U L A T I O N U

M O R Y B C E L L S A

B L Y M P
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M P K I L E M E A N T S Y S T E M T L

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2 1 S S T L
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H A G O C Y N T I C C E L L S

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N D L I N D E O F D E F E N C E

N S P E C I F I C D E F E N C

I P E N E O F D E F E N C E

H O C Y T E S

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E M O R Y T C E L L

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R E S I S T A N C

M A C R O P H A G C E S P

N A T E

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