PATHOPHYSIOLOG Y Hematogenous spread (ex.

Tricuspid Direct

Microorganis m

Aspiration from

Contiguous extension from an infected pleura or

Goblet cells produce mucus containing lysozome and IgA Eliminates via mucociliary elevators Coug

Defense mechanism Mucociliary clearance Cough Gag

Macrophage kills the bacteria

Alveolar macrophage Alveolar macrophage + Complement antibodies + surfactand prodtein A and D Host inflammatory response

IL 8 and granulocyte colony-stimulating factor

Release of inflammatory mediators Alveolar capillary

Feve

Stimulate neutrophil release (GRAY hepatization)

Rales/Crack Exudate in Infiltrates on Chest XHemopty

Peripheral leukocytosis and inc. purulent secretions

Erythrocyte in intraalveolar exudates (RED

Dec. lung VQ Inc. respiratory Dyspnea Tachypn