Schematic Diagram of Stroke

Due to thrombosis or embolism, some neurons die because of lack of oxygen and nutrients Impaired cerebral tissue perfusion (Hemorrhagic)

Infarction of the Cerebral Vessels known as Stroke

Tissue injury triggers an inflammatory response which increases intracranial pressure

Space- occupying blood clots put more pressure on the brain tissues.

The injury disrupts metabolism leading to changes in ionic transport, localized acidosis, and free radical formation

The regulatory mechanisms of the brain attempt to maintain equilibrium by increasing BP and ICP.

Calcium, sodium, and water accumulate in the injured cells and excitatory neurotransmitters are released

The ruptured cerebral vessels may constrict to limit blood loss however; this vasospam will result to further ischemia and necrosis of brain tissues.

Continued cell cellular injury and swelling both occurs resulting to further cell damage

Brain Death