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Authored By: Allison DiMatteo Reviewed By: Mahnaz Fatahzadeh, DMD Oral thrush or oral pseudomembranous candidiasis is a fungal infection of the mouth common among denture wearers, infants and people with weakened immune systems. The most common human fungal infection, oral thrush presents as slightly raised removable plaques (resembling cottage cheese) on the tongue or inner cheek. Thrush can also affect the roof of the mouth, gums, tonsils or back of the throat. There are three other forms of oral candidiasis infections:
Erythematous candidiasis appears as red patches on the roof of the mouth and tongue. Hyperplastic (chronic) candidiasis resembles the more common type, but cannot be scraped off. Angular cheilitis looks like red sores that develop in the corners of the mouth.
Oral thrush is caused primarily when there is an overgrowth of Candida albicans, a yeast normally present in the mouth in small quantities and kept in balance by helpful bacteria in the body. Less frequently, oral thrush may also be caused by an overgrowth/infection of the Candida glabrata or Candida tropicalis yeasts, which also are present in the mouth. Dry mouth, high blood and salivary sugar levels (diabetes), and prolonged use of certain antibiotics or corticosteroid therapy (asthma inhalers) can upset the body's natural balance of friendly bacteria that would otherwise fight off a yeast infection. This allows overgrowth of Candida and leads to oral thrush.
Mothers and their infected infants can pass oral thrush back and forth. For a breastfeeding mother, Candidal infection could result in burning, painful nipples. Candidal infections can also cause vaginal yeast infections in women. Candidiasis is not limited to the mouth and, if left untreated, can spread to other parts of the body (throat, vagina, skin). Although rare, oral thrush can spread to other organs of the body, but this is usually limited to immunocompromised individuals. Your dentist can diagnose oral thrush by examining your mouth and brushing the lesions away. If necessary, microscopic testing can be used for confirmation.
Investigations Consider the following investigations in patients presenting with angular cheilitis:
CBC, ferritin, B12, folate, fasting blood sugar, HbA1C swab for bacterial culture and sensitivity, and candidiasis
Consider referral to dermatologist who may biopsy any lesions suspicious of malignancy, e.g. if there is induration or ulceration. The dermatologist may also see about patch testing if its a possible ACD. Treatment The keys to successful management include treating any underlying causes and modifying habits that may worsen the condition. Patients should be instructed to ensure optimal denture fit, and remove dentures nightly with regular cleansing. Tell patients to apply a barrier moisturizer to the lips frequently. Have them try petroleum jelly or zinc oxide ointments, especially before bed and meals. Topical antifungals that are effective against yeasts are the mainstay of therapy. Clotrimazole and nystatin creams are good options. Use topical antibiotics if bacterial superinfection is likely. Fusidic acid, polymyxin B, and mupirocin are possible options. Mild topical corticosteroids and topical calcineurin inhibitors (pimecrolimus, tacrolimus) are additional options if inflammation is obvious. Combinations such as 1% hydrocortisone in clotrimazole cream can also be helpful. If these arent effective, oral antifungals, e.g. fluconazole, should be considered. Mechanical correction of deep folds, such as collagen injection, is rarely done for select cases. Case discussion We discussed the nature of angular cheilitis with our patient, and took swabs for bacterial and fungal culture and sensitivity. Blood work included CBC, ferritin, fasting blood sugar and HbA1C. We instructed our patient to avoid lip licking and cinnamon-flavoured toothpaste, and to apply petroleum jelly to the lips and angles before eating and sleep. We also prescribed clotrimazole cream to use twice daily at the angles of the mouth.
Charles Lynde, MD, FRCP(C) is an assistant professor of dermatology at the University of Toronto. John Kraft, MD, is in his third year of the Dermatology Residency Program at the University of Toronto.
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