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Application Note 4 XL Coater

OYSTAR Manesty Kitling Road, Knowsley Merseyside, England L34 9JS Tel: +44 (0)151 547 8000 Fax: +44 (0)151 547 8001 e-mail: sales@oystar.manesty.com Web: www.oystar.manesty.com

Sugar coating of multivitamin tablets The Manesty XL coater has the flexibility to enable the seal coat of moisture sensitive products to be applied by a film coating process and the sub coat and colour coating stages to be applied using a sugar dosing bar. The changeover between the two stages is simple as the same pumping system can be used for both film and sugar coating

Double Headed Peristaltic Pump

Sugar Coated Tablets

Many multivitamin tablets that are sugar coated are moisture sensitive. Because of the nature of the sugar coating process it is necessary to seal the product from moisture ingress prior to sugar coating This sealing stage can be applied as a film of Opadry AMB or Sepifilm LP. Table 1 shows suggested process parameters when film coating with Opadry AMB and Sepifilm LP on the Manesty XL

Table 1 Suggested process parameters when film coating with Opadry AMB or Sepifilm LP
Coating suspension Solids concentration (% w/w) Batch size (kg) Inlet temperature (C) Exhaust temperature (C) Spray rate (g/min) Drum speed (r.p.m) Airflow (m3/hr) Cabinet Depression (Pa) Gun to bed distance (cm) Atomising air pressure (bar) Fan air (bar) Baffle System Gun details Peristaltic tubing Tablet Weight gain (%) Coating time (mins) Coating Efficiency (%) Sepifilm LP 12 1.5 65 36 37 7-8 15 328 -35 13 1.5 1.2 Ploughshare 1 Manesty with 1.2mm nozzle Silicone; 3.2mm bore; 1.6mm wall 3 52 99.5 Opadry AMB 20 3.0 65 39 9 15 322 -30 11 1.5 1.5 Ploughshare 1 Manesty with 1.2mm nozzle Silicone; 3.2mm bore; 1.6mm wall 4 68 99.7 Sepifilm LP 12 3.2 65 35 36 14 22 334 -45 14 1.5 1.5 Ploughshare 1 Manesty with 1.2mm nozzle Silicone; 3.2mm bore; 1.6mm wall 3 58 99.5 Opadry AMB 15 5.5 65 35 - 38 11 - 15 15 341 -50 13 1.5 1.5 Ploughshare 1 Manesty with 1.2mm nozzle Silicone; 3.2mm bore; 1.6mm wall 4 102 99.9

Sugar sub-coat and colour coating stages 6kg of multivitamin tablet cores were first seal coated with a 4% weight gain of Opadry AMB. These cores were then sugar coated. Table 2 shows the formulation details for each of the sugar coating stages. The tablets were polished by addition of 7g of micronised carnauba wax to the drum with the inlet and exhaust fans switched off. The tablets were tumbled at 20 rpm for 10 minutes at ambient temperature during the polishing phase.

Table 2 Formulation details for the three sugar coating stages


Stage Formulation Sub Coat Rapid Build Up Material % w/w Sepifilm SC 65 758 (white) water 35 Smoothing Coat Material Simple Syrup (70 %w/w sucrose) Titanium Dioxide Start 921 155 % w/w 87 Colour Coat Material Opalux (orange) % w/w 12.5

13 Simple Syrup Finish 1047 Start 921 210

87.5

Tablet weight (mg) Process time (mins)

Start 834 170

Finish 921

Finish 1168

Table 3 Sugar Coating process parameters using formulations in Table 2


Stage Sub coat Smooth coat Colour coat Colour coat (2) No. of Doses 35 40 25 5 Dose (g) 70 60 30 30 Roll (sec) 120 - 180 160 - 180 150 400; 300 and 200 Dry (sec) 100 90 120 N/a Drum Speed (rpm) 14 9 - 14 6- 9 7 Inlet Airflow (m/hr) 400 400 400 N/a Inlet Temp ( C) 36 - 37 45 34 - 40 ambient Exhaust Temp ( C) 26 - 29 34 28 - 32 ambient

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