All can cause pneumonia Characteristics Dimorphic fungi Except

Disseminate

Coccidioides

Histoplasma capsulatum

Pneumonia

Tuberculate macroconidia

Macroconidia Mold in soil Properties Dimorphic

Paracoccidioides basiliensis

Latin America

Endemic to Yeast in tissue

Inhaled

Pathogenesis & clinical ndings Fever Systemic symptoms Weight loss Paracoccidioides Histoplasma Symptoms Painful oral ulcers

"Captain's wheel"

Multiple buds

Tissue samples

Lymphadenopathy

Hepatosplenomegaly

X-ray

Hilar adenopathy

Pneumonia and meningitis

Coccidioides immitis
Systemic mycoses

Transmission & epidemiology

Ohio and Mississippi valleys

Soil contaminated with

Bird droppings

"Valley fevers"

Southwestern US, California

Endemic to

Can be inhaled

Arthrospores

Spore in dust

Case rate after earthquakes

Tissue samples

Oval budding yeast in macrophages

Coccidioides

Spherules lled with endospores

Tissue samples

Blastomyces dermatitidis

Endemic to Bone Can disseminate to Skin Can disseminate to

Great Lakes, Ohio, Mississippi River regions

Cause inammatory lung disease

Skin

Bone Blastomyces

Tissue samples

Big, Broad-based Budding