BOOK-BASED PATHOPHYSIOLOGY

Endothelial damage

Vasospasms

Increased thromboxane to prostacydin

Fluid shifts from intravascular to intracellular

Increased endothelin & decreased nitric oxide

Intravascular coagulation

Increased sensitivity to angiotensin II

Generalized vasoconstriction

Uteroplacen tal arteriole lesions

Glomerular damage

Cortical brain spasms

Pulmonary edema

Proteinuria Hypertension
-IUGR -Abruption of placenta -increased uterine contractility

Headache
Edema of the hands face and abdomen (dependent) Hyperreflexia

Dyspnea

Seizure Hepatic micro emboli; Liver damage

Retinal arteriaolar spasms

Haemolysi s of RBCs

Platelet aggregatio n and fibrin deposition

-Blurred vision

-Decreased haemoglobin -Maternal hyperbilirubinem ia

Thrombocytopeni a Disseminated intravascular coagulation

-elevated liver enzymes -Nausea and vomiting -Epigastric pain -Right Upper Quadrant Pain -Decreased blood glucose