LEONARDO BALDASSARRE

C.da Pagliarone, 1/a 65019 Pianella (Pescara) Italy Tel.: +39 329 4262084 E-mail: leonardo.baldassarre@unina.it

PERSONAL INFORMATION Date of Birth: 30-01-1985 Gender: Male Nationality: Italian

EDUCATION March 2013 to present National Research Council, Institute of Molecular Bioimagining and Physiology, Segrate (Milan), and Interuniversity Centre for Bioactive Peptide Research, Naples. Post-doctoral Research Fellowship Research project: synthesis of novel multi-cyclic peptides possessing nerve growth factor agonist activity. 2010 2013 University G. dAnnunzio of Chieti-Pescara, Department of Pharmacy Ph.D. in Medicinal Chemistry (Doctor Europaeus). Thesis: Synthesis and Biological Evaluation of New Antimicrobial Peptides and Peptidomimetics. Advisor: Prof. Francesco Pinnen March 2013 to October 2013 University Of Cambridge, Department of Chemistry Visiting PhD student. Research project: Biomimetic total synthesis of natural product Bussealin E. Advisor: Dr. David R. Spring 2004 2009 University G. dAnnunzio of Chieti-Pescara, Department of Pharmacy First-class honour degree in Pharmaceutical Chemistry and Technology. Thesis: Synthesis and pharmacological evaluation of ibuprofen-glutathione codrug as novel anti-alzheimer agent. Advisor: Prof. Francesco Pinnen

1999-2004 I.S.S. Luigi di Savoia, Chieti Diploma in Chemistry.

ATTENDANCE AT CONFERENCES, SEMINARS AND SCHOOLS June 27 - July 2, 2012 Italian Chemical Society - European Federation for Medicinal Chemistry European School of Medicinal Chemistry: XXXII Advanced Course of Medicinal Chemistry and E. Duranti National Seminar for PhD Students. July 3 - 8, 2011 Italian Chemical Society - European Federation for Medicinal Chemistry European School of Medicinal Chemistry: XXXI Advanced Course of Medicinal Chemistry and E. Duranti National Seminar for PhD Students. May 2011 University G. dAnnunzio of Chieti-Pescara - Nazarteh College of Rochester Scientific English Course: Writing Across Science July 4 - 9, 2012 Italian Chemical Society - European Federation for Medicinal Chemistry European School of Medicinal Chemistry: XXX Advanced Course of Medicinal Chemistry and E. Duranti National Seminar for PhD Students.

SKILL AND COMPETENCE Technical skills and competences Wide experience in synthetic organic chemistry, including natural products synthesis, peptide synthesis, peptide modification, design and synthesis of peptidomimetics. Competent with automated peptide synthesizer (Protein Technology Symphony and Prelude), NMR spectrometers, LC/MS systems, and HPLC systems coupled with UV and mass detectors. Excellent skill in mass spectrometry techniques (ESI and MALDI). Knowledge of molecular modeling and molecular dynamic and use of computational chemistry tools as HyperChem, VegaZZ and Autodocking tools.

Language Mother tongue: Italian Other languages: English and French Self-assessment*: Understanding English French Listening B2 Listening A2 Reading C2 Reading C1 Speaking Spoken interaction Spoken production B2 C1 Spoken interaction Spoken production A2 A2 Writing B2 A1

(*) Common European Framework of Reference for Languages

Social skills and competences Good interpersonal and communication skills and ability to establish and maintain good work relationships with people of different nationality and cultural backgrounds. Organizational skills and competences Flexible, experienced, and highly organized. Positive approach to hard work and able to work both under supervision and independently with enthusiasm and problem-solving attitude. Computer skills and competences Use of Microsoft Windows and Apple OS X operative systems. Use of Office suite and iWork suite. Use of ChemOffice package and Prism. Experience with molecular computer graphic software such as Chimera and Pymol.

PUBLICATIONS 1. Cacciatore, I., Cornacchia, C., Fornasari, E., Baldassarre, L., Di Stefano, A., Sozio, P., Marinelli, L., Dean, A., Fulle, S., Di Filippo, E. S., La Rovere, R. M. L., Patruno, A., Ferrone, A., Di Marco, V. A glutahione derivative with chelating and in vitro neuroprotective activities: synthesis, physico-chemical properties and bioevaluation. ChemMedChem, Accepted Manuscript 2. Simonetti O., Cirioni O., Mocchegiani F., Cacciatore I., Silvestri C., Baldassarre L., Orlando F., Castelli P., Provinciali M., Vivarelli M., Fornasari E., Giacometti A., Offidani A. The efficacy of the quorum sensing inhibitor FS8 and tigecycline in preventing prosthesis biofilm in a animal model of staphylococcal infection. International Journal of. Molecular Science, 2013, 14, 16321-16332.

3. Baldassarre, L., Fornasari, E., Catia Cornacchia C., Cirioni, O., Silvestri, C., Castelli, P., Giocometti, A., Cacciatore, I. Discovery of novel RIP derivatives by alanine scanning for the treatment of S. aureus infections. MedChemComm, 2013, 4, 1114-1117. 4. Cacciatore, I., Fornasari, E., Baldassarre, L., Cornacchia, C., Fulle, S., Di Filippo, E., Pietrangelo, T., Pinnen, F. A Potent (R)-alpha-bis-lipoyl Derivative Containing 8Hydroxyquinoline Scaffold: Synthesis and Biological Evaluation of Its Neuroprotective Capabilities in SH-SY5Y Human Neuroblastoma Cells. Pharmaceuticals, 2013, 6, 5469. 5. Cirioni, O., Mocchegiani, F., Cacciatore, I., Vecchiet, J., Silvestri, C., Baldassarre, L., Ucciferri, C., Orsertti, E., Castelli, P., Provinciali, M., Vivarelli, M., Fornasari, E., Giacometti, A. Quorum Sensing Inhibitor FS3-coated Vascular Graft Enhances Daptomycin Efficacy in a Rat Model of Staphylococcal Infection. Peptide, 2013, 40, 77-81. 6. Cacciatore, I., Baldassarre, L., Fornasari E., Cornacchia C., Di Stefano A., Sozio P., Cerasa L. S., Fontana A., Fulle S., Di Filippo E. S., La Rovere R. M. L., Pinnen F. (R)--Lipoyl-GlycylProlyl-l-Glutamyl Dimethyl Ester Codrug as a Multifunctional Agent with Potential Neuroprotective Activities. ChemMedChem, 2012, 7, 2021-2029. 7. Baldassarre, L., Pinnen, F., Cornacchia, C., Fornasari, E., Cellini, L., Baffoni, M., Cacciatore, I. Synthesis of short cationic antimicrobial peptidomimetics containing arginine analogues. Journal of Peptide Science, 2012, 18, 567-578. 8. Cacciatore I., Baldassarre, L., Fornasari E., Mollica A., Pinnen F. Recent advances in the treatment of neurodegenerative diseases based on GSH delivery systems. Oxidative Medicine and Cellular Longevity, 2012, 240146. 9. Cacciatore I., Cornacchia C., Baldassarre, L., Fornasari E., Mollica A., Stefanucci A., Pinnen F. GPE and GPE analogues as promising neuroprotective agents. Minireview in Medicinal Chemistry, 2011, 12, 13-23. 10. Cornacchia C., Cacciatore I., Baldassarre, L., Mollica A., Feliciani F., Pinnen F. 2,5diketopiperazines as neuroprotective agents. Minireview in Medicinal Chemistry, 2011, 12, 212.

POSTER COMMUNICATIONS Baldassarre L., Novel small antimicrobial peptidomimetics containing arginine analogues. European School of Medicinal Chemistry: XXXII Advanced Course of Medicinal Chemistry and E. Duranti National Seminar for PhD Students. Urbino, Italy, 27 June - 2 July 2012.

Fornasari E., Cacciatore I., Baldassarre L., Mollica A., Costante R., Pinnen F., Synthesis of GPE analogues as potential neuroprotective agents. 13th Naples Workshop on Bioactive Peptides. Napoli (NA), Italy, 7-10 June, 2012. Fornasari E., Cacciatore I., Cornacchia C., Baldassarre L., and Pinnen F., Synthesis and Neuroprotective and Antioxidant activity evaluation (R)--Lipoyl-Glycyl-Prolyl-l-Glutamyl Dimethyl Ester Codrug as a Multifunctional Agent for the Treatment of Neurodegenerative diseases. XXXI TUMA Interregional Conference, Francavilla al mare, Italy, 18-20 June, 2012.