Beruflich Dokumente
Kultur Dokumente
Biomedical Laboratories
The University of Texas at Tyler
IACUC Education and Training
*Note: Content not specific to UT Tyler is from the American
Association for Laboratory Animal Science (AALAS)
Principles of BioSafety
Secondary containment is
provided by a combination
of facility design and
operational practices.
Ventilation systems,
controlled access, airlocks,
and other facility design
features must be part of any
biosafety program.
Principles of BioSafety:
Biological Safety Cabinets
Safety equipment includes biological safety
cabinets (BSCs), enclosed containers, and
other engineering controls designed to remove
or minimize exposures to hazardous biological
materials.
Personal protective
equipment (PPE) is often
used in combination with
biological safety cabinets
and other devices that
contain the agents, animals,
or materials being handled.
It may be difficult or
impractical to work in
biological safety cabinets in
some situations; in this
instance, personal protective
equipment may form the
primary barrier between
personnel and the infectious
materials.
Principles of Biosafety: The
Facility as a Barrier
Facility design and
construction contribute to
the laboratory workers'
protection, provide a
barrier to protect persons
outside the laboratory,
and protect people and
animals in the community
from infectious agents
which may be
accidentally released
from the laboratory.
Principles of Biosafety: The
Facility as a Barrier
Laboratory management is responsible for
providing facilities that are commensurate with
the laboratory's function and with the
recommended biosafety level for the agents
being manipulated.
Biosafety Level 1
BSL-1 laboratories are used to study
agents not known to consistently cause
disease in healthy adults.
Route of Transmission
Agents transmitted by the aerosol route
have caused the most laboratory
infections, versus agents transmitted
parenterally or by ingestion. When
planning work with an unknown agent with
an uncertain mode of transmission, the
potential for aerosol transmission must be
considered due to the higher risk.
Risk Assessment
Agent Stability
Desiccation, exposure to sunlight or
ultraviolet light, exposure to chemical
disinfectants and other factors can affect
the agent's stability in the environment.
Risk Assessment
Infectious Dose
Infectious dose can vary from one to
hundreds of thousands of units.
Risk Assessment
Susceptibilty
The infectious dose is affected by the individual's
resistance, so a laboratory worker's immune status
is directly related to his/her susceptibility to disease
when working with an infectious agent. Thus,
susceptibility may be greater than in a healthy
person for persons who are pregnant, have
undergone surgery, are receiving immune-
suppressent medications (including steroids), or
who have systemic infectious diseases.
Risk Assessment
Origin
Origin may refer to geographic location
(e.g., domestic or foreign); host (e.g.,
infected or uninfected human or animal); or
nature of source (potential zoonotic or
associated with a disease outbreak).