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Goljan High Yield for Cell Injury USMLE 1 Study this set online at: http://www.cram.com/cards/952055 tissu

Goljan High Yield for Cell Injury USMLE 1

Study this set online at: http://www.cram.com/cards/952055

tissu e h yp o xia - in a d e q u a te O 2 re a ch in g tissu e s

1. ish e mia -

2. h yp o xe mia - lo w Pa O 2

list 5 causes of tissue hypoxia

3. p ro b le ms with o xid a tive p a th wa y

in mito ch o n d ria

4 u n co u p le s o x/p h o s in mito ch o n d ria

5. AV sh u n tin g

Definition- decreased arterial blood flow to tissue and give 2 examples

ischemia

atherosclerosis like in MCC

decreased cardiac output

definition- low arterial partial pressure of O2. list 4 examples

h yp o xe mia

1. re sp ira to ry a cid o sis

2. ve tila tio n p ro b le ms like in a te le cta sis (RDS, ARDS)

3. p e rfu sio n p ro b le ms- in cre a se s d e a d sp a ce p u lmo n a ry e mb o lu s

4. d iffu sio n - in te rstitia l fib ro sis in lu n g s

5. a n e mia

6 . CO

p o iso n in g

7. me th e mo g lo b in 8 . le ft sh ift o f O DC

how do CN and CO cause tissue hypoxia

inhibit complex 4 in miochondria so cause problems in ox/phos which decreases amount of ATP and causes tissue hypoxia

what do uncouplers do and list 4 examples

re n d e r in n e r mito ch o n d ria l me mb ra n e p e rme a b le to p ro to n s wh ich d e cre a se s ATP syn th e sis

1. a lco h o l

2. sa licyla te s 3. DNP

4. Va lin o mycin

name 3 ways other than congenitally that a person can develop an AV shunt

1. AV fistula from trauma

2. spider angioma due to hyperestrinism

3. mosaic bone in Paget's

list 3 main effects is there is a decrease in ATP in cell

1. cell must use anaerobic glycolysis to generate ATP

2. impaired Na/K pump

3 ribosomes fall off RER

how is phosphofructokinas (PFK) activated

1. by low citrate

2. increase in AMP

Goljan High Yield for Cell Injury USMLE 1 Study this set online at: http://www.cram.com/cards/952055 why

Goljan High Yield for Cell Injury USMLE 1

Study this set online at: http://www.cram.com/cards/952055

why is a decrease in intracellualr pH when there is a decrease in ATP

bc cell must used anaerobic glycolysis and the last step is to convert pyruvate to lactate which is an acid this degenerates cell enzymes an other proteins causing coagulative necrosis and producing a large anion gap metabolic acidosis

what is the difference bwt O2 content, PaO2 and SaO2

O2 content- total am ount of O2 carried in blood

PaO2- am ount of O2 dis s olved in plam s a

SaO2- percentage of O2 atached to the 4 hem e groups in Hb within RBC, norm al range is 94-96%