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diversion/duodenal switch 16 (67%). Purely restrictive procedures were performed in 24 (100%) of the countries, restrictive/malabsorptive in 21 (88%), and primarily malabsorptive in 18 (75%). Conclusions: Bariatric surgery is expanding exponentially to meet the global epidemic of morbid obesity. Operative procedures in bariatric surgery are in flux and specific geographic trends and shifts are evident. Yet, of the patients qualifying for surgery, only about 1% are receiving this therapy the only effective treatment currently available. Key words: Morbid obesity, bariatric surgery, gastric bypass, gastric banding, gastroplasty, biliopancreatic diversion, duodenal switch, laparoscopy
Introduction
There is a world epidemic of overweight (body mass index [BMI] 25) and obesity (BMI 30), estimated to encompass 1.7 billion people.1,2 According to the Worldwatch Institute, the number of overweight people is approximately equal to the number of underweight people.3 Of all the world's nations, the percentage of adult overweight is highest in the United States (about 60%).4-7 However, overweight people are in excess of 50% in Russia, the United Kingdom, and Germany; 20% in Colombia, Brazil, Italy, Austria, and Switzerland; and even 10% in China.8 In Australia, 41% of adult men and 23% of adult women are overweight. In the Federated States of Micronesia, 80% of women 40 to 49 years old are overweight and over 50% are obese.8 Globalization, stated to be an undeniable economic evolution, appears also to be an undeniable weight evolution. Morbid obesity (BMI 40 or BMI 35 in the presence of significant co-morbidities9) is estimated to afflict about 20% of the obese population.4-7 It is in this population that bariatric surgery has come to the
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forefront as the only current mode of therapy that is reasonably successful. Bariatric surgery not only markedly lowers body weight, but reverses or ameliorates the myriad of obesity co-morbidites (e.g., type 2 diabetes, hypertension, hyperlipidemia, heart disease, stroke, asthma, obstructive sleep apnea, back and lower extremity weight-bearing degenerative problems, many forms of cancer, depression, etc.) responsible for >2.5 million deaths per year worldwide.10 The response of the world community of bariatric surgeons to the obesity epidemic was the creation of the International Federation for the Surgery of Obesity (IFSO) in 1995. Since 1999, the annual IFSO congresses have included the International Symposium on Laparoscopic Obesity Surgery (ISLOS), and since 2003, Executive Council membership for Allied Health. The first president of IFSO was Nicola Scopinaro of Genoa, Italy, whose 1997 Presidential Address served as the precursor for this report.11 At present, IFSO has 31 member nations with Sweden as a correspondent nation. The absence of a current international review of bariatric surgery number of cases, number of surgeons, membership in IFSO, and the relative distribution of the standard bariatric operations worldwide and per nation has stimulated this report. These data are based on the compilation and tabulation of responses to an e-mail survey.
4. When did your country join IFSO? The questionnaire also requested the relative percentage of open and laparoscopic operations, and the relative percentage of the following specific bariatric procedures performed: Open adjustable gastric banding Laparoscopic adjustable gastric banding Open gastric bypass Laparoscopic gastric bypass Open long-limb gastric bypass Laparoscopic long-limb gastric bypass Open vertical banded gastroplasty Laparoscopic vertical banded gastroplasty Open biliopancreatic diversion Laparoscopic biliopancreatic diversion Open duodenal switch Laparoscopic duodenal switch Other (specify)
Data Analysis
For the tabulation of findings, the supplied data are presented. For the calculation of relative prevalence of specific procedures, weighted averages are used to compensate for the wide ranges of the number of procedures performed: % Variable x Number of Variable ______________________________ Number of Variable
Total (Responders) 2,839 Table 3. Question 3 - When did bariatric surgery start in your country? Argentina - 1988 Australia (New Zealand) - 1960 Austria - 1973 Belgium (Luxembourg) - 1970 Brazil - 1973 Czech Republic - 1983 Egypt - 1996 France - 1984 Germany - 1975 Greece - 1978 Hungary - 1999 Israel - 1978 Italy - 1973 Japan - 1982 Mexico - 1971 Netherlands - 1973 Panama - 1989 Poland - 1974 Russia - 1969 Spain - 1977 Sweden - 1970 Switzerland - 1970 Turkey - 1990 Ukraine - 1978 United Kingdom - 1955 USA/Canada - 1953
103,000. Nations performing 2,000 operations or more annually were France, 12,000; Belgium, 6,000; Brazil, 4,000; Italy, 3,000; Australia (New Zealand), 2,750; Egypt, 2,750; Mexico, 2,500; and Spain, 2,000.
Earliest Start Date 1953 USA Latest Start Date 2002 Panama
They were joined in 1996 in Prague by Austria, Belgium (Luxembourg), Brazil, Germany, Greece, and the Netherlands, and in 1997 in Cancun by France, Israel, Paraguay, and Spain (Table 4, Figure 2).
Open vs Laparoscopic
Of the 26 responder nations (or national groupings), the relative percentages of open procedures vs laparoscopic were 37.15% to 62.85%. Thus, today, nearly two-thirds of the world's bariatric surgery is performed laparoscopically.
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30 27 25 25 22
No. of Nations
35 30 30 25 20 20 15 15 10 8 17 20 24 25 31
No. of Nations
20 15 10 5 0 1950 1960 4 2
17
1970
1980
1990
2000
Figure 2. Cumulative number of nations (or national groupings) joining IFSO by year.
Figure 1. Cumulative number of nations (or national groupings) starting bariatric surgery by decade since 1950.
given in Table 6. The number of nations (or national groupings) performing specific bariatric procedures and the relative percentages for this 24-nation subset is given in Table 7.
Derivative Data
When the open and laparoscopic procedures are pooled in the 24 nations cohort, with biliopancreatic diversion/duodenal switch considered a single category, gastric bypass took a commanding world lead (65.11%), followed by gastric banding (24.41%), vertical banded gastroplasty (5.43%), and biliopancreatic diversion/duodenal switch (4.85%) (Figure 4). Categorizing the procedures by weighted averages
Table 5. Bariatric surgery procedures worldwide % Laparoscopic gastric bypass Laparoscopic adjustable gastric banding Open gastric bypass Laparoscopic long-limb gastric bypass Open long-limb gastric bypass Open vertical banded gastroplasty Open duodenal switch Laparoscopic vertical banded gastroplasty Laparoscopic biliopancreatic diversion Open biliopancreatic diversion Laparoscopic duodenal switch Open adjustable gastric banding Laparoscopic gastric pacing Laparoscopic nonadjustable gastric banding Open jejunoileal bypass 25.67 24.16 23.07 8.92 7.45 4.25 2.03 1.18 1.09 0.87 0.85 0.17 0.15 0.08 0.07
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20%
15%
0% Lap. Gastric BypassLap. Adjustable Gastric Banding Open Gastric Bypass Lap. Long-Limb Open Long-Limb Gastric Bypass Gastric Bypass Open Vertical Banded Gastroplasty
into the functional categories of restrictive/malabsorptive (gastric bypass standard and long-limb), purely restrictive (gastric banding, vertical banded gastroplasty), and primarily malabsorptive (biliopancreatic diversion, duodenal switch), their relative distribution is 65.11%, 29.84%, and 4.85%, respectively. Looking at the popularity of procedures worldwide, i.e. the number of nations (or national groupings) performing certain procedures, 23 of the 24 (96%) perform gastric banding; 21 (88%), gastric bypass (standard and long-limb); 19 (79%), vertical banded gastroplasty; and 16 (67%), biliopancreatic diversion/duodenal switch. Thus, in the year 20022003, gastric banding was performed in all but 1 of the 24 responding nations (or national groupings). Within functional categories, purely restrictive procedures (gastric banding and vertical banded gastroplasty) were performed in 24 of the 24 nations (100%), restrictive/malabsorptive (gastric bypass, standard and long-limb) in 21 (88%), and primarily malabsorptive (biliopancreatic diversion and duodenal switch) in 18 (75%) (Figure 5).
Discussion
This tabulation and analysis of bariatric surgery worldwide is the first major attempt to perform such a function since the paper by Scopinaro in 1998, over 5 years ago.11 During this time interval, the number of annual bariatric surgery operations has increased from 40,000 to 146,301 worldwide an
increase of 266%. The number of IFSO societies has increased from 14 to 31 an increase of 121%. The data in this paper are limited by certain factors: not all nations performing bariatric surgery belong to IFSO, the response rate from the IFSO member nations (or national groupings) was less than 100%, and within each nation delineation of the number of procedures and the number of bariatric surgeons, more than likely, was not precise. Furthermore, for the relative prevalence of specific procedures, the available numbers were even less precise; an exception was the information obtained from Italy, which has a functioning and inclusive bariatric surgery registry.12 Finally, there were several discrepancies in the data supplied by some of the responders, which we corrected to the best of our knowledge. Nevertheless, the information in this study gives a fairly accurate overview of this field and provides data for a contemplation of trends. Certain conclusions can be drawn from these findings. As in all other surgical fields, operative procedures are always in flux. There is no gold-standard bariatric procedure and, probably, never will be. It was just a number of years ago that vertical banded gastroplasty was not only the primary purely restrictive operation performed but in the USA the most commonly performed bariatric procedure.13 Today, vertical banded gastroplasty in the USA/Canada comprises only 1.4% of bariatric procedures. Again, in the USA/Canada before 2002, laparoscopic adjustable gastric banding was not performed at all outside of trials sanctioned by the Food and Drug Administration (FDA).13 Currently, 9% of bariatric procedures in the USA/Canada are laparoscopic adjustable gastric banding operations. Worldwide, the percentage of biliopancreatic diversion/duodenal switch procedures is growing. New operations (e.g., gastric pacing) are being introduced and may well become popular. Definite geographic trends and shifts are observable in the specific bariatric procedures being performed. Biliopancreatic diversion started in Genoa, Italy; it was converted to the duodenal switch in the USA/Canada;14 and now these two operations are both becoming more widely employed in Europe. Certainly, laparoscopic adjustable gastric banding was a European, Australian, and South American procedure until recently and its introduction into the USA/Canada. In return, Europe and nations outside
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Table 6. Countries performing specific procedures of 24 responders Procedures (%)
Nations LRGB LAGB ORGB LLLLOVBG ODS LVBG LBPD LRGB ORGB OBPD LDS OAGB LGP LNAGB OJIB
Argentina Australia (New Zealand) Austria Belgium (Luxembourg) Czech Republic Egypt France Germany Greece Hungary Israel Italy Japan Mexico Netherlands Poland Russia Spain Sweden Switzerland Turkey Ukraine United Kingdom USA/Canada
5 4 1.5
80 80 98 70
5 4 7
1 1
1 1
1 1
1 1 0.5
6 1
0.5
1.5 15
5 10 5 2 1
80 25 80 90 15 95 90 5 1 70 0.5 25 10 10 40 15 6 37 4 5 14 30 17 5 38 10 1 23 5 2 2 3 20 3 5 8 2 3 20 1 4 3 1 4 1 1 4 10 26 3 4 6 5 10 25 10 30 12 10 5 8 1.1 20 1 2.5 0.3 1 20 2 1 20 2 0.1 3 5 1.4 13 20 7 14 1 10 1 10 0.3 0.2 1 0.8 0.02 5
41
10 4
60 75 10 40
10 5 8 7 34
1 1
32 15
16 22 20
6 10 45 90 10
2 33
75 9
KEY: LRGB=laparoscopic Roux gastric bypass; LABG=laparoscopic adjustable gastric banding; ORGB=open Roux gastric bypass; LLLRGB-long-limb laparoscopic Roux gastric bypass; LL-ORGB=long-limb open Roux gastric bypass; OVBG=open vertical banded gastroplasty; ODS=open duodenal switch; LVBG= laparoscopic vertical banded gastroplasty; LBPD=laparoscopic biliopancreatic diversion; OPBD=open biliopancreatic diversion; LDS=laparoscopic duodenal switch; OAGB=open adjustable gastric banding; LGP=laparoscopic gastric pacing; LNAGB=laparoscopic nonadjustable gastric banding; OJIB=open jejunoileal bypass. NOTE: Specific breakdown of procedures is not available for Brazil or Panama, although 96% of the procedures in Brazil are LRGB and LAGB.
of the USA/Canada have become more receptive to laparoscopic gastric bypass. The annual IFSO meetings, throughout the world, have had a major role in this cross-fertilization process. Bariatric surgery is expanding exponentially to address the global epidemic of morbid obesity. The success of bariatric surgery will stimulate research into the origins of obesity and into biochemical
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ways to ameliorate this disease. Eventually, pharmaceutical agents will assume part of the therapeutic burden and may, indeed, work in concert with bariatric surgery a synergistic or hybrid approach to therapy. In the USA, bariatric surgery is currently used to treat 1% to 2% of the morbidly obese population qualifying for operative therapy by the outdated cri-
Primarily Malabsorptive
(Biliopancreatic Diversion/ Duodenal Switch)
teria of the 1991 National Institutes of Health (NIH) Consensus Conference.9 Elsewhere in the world, the percentage of qualifying individuals who actually undergo bariatric surgery is even less. The ratio of the number of patients with the disease of morbid obesity to the number being treated by the only currently effective therapy bariatric surgery would not be tolerated by healthcare organizations or the public, if the disease were any other than morbid obesity and if the therapy were any other than surgical. The next few years, or decade, will be critical in the growth, maturation, and assessment of bariatric surgery worldwide. We plan to update this study, if feasible, on a periodic basis.
We wish to thank Dr. Nicola Scopinaro for his original assessment of bariatric surgery worldwide and his help in reviewing some of these data. We also thank Dr. Mervyn Deitel for providing facts, insights, and time. We are grateful to the international contributors of information, the responders to our e-mail survey, that made this effort possible: Argentina - Dr. Carlos A. Casalnuovo; Australia (New Zealand) - Dr. Paul E. O'Brien and Dr. Andrew C. Jamieson; Austria - Dr. Karl A. Miller; Belgium (Luxembourg) - Dr. Luc Lemmens; Brazil - Dr. Fernando Barosso; Czech Republic - Dr. Martin Fried; Egypt - Dr. Essam Abd-El Galil; France - Dr. Jerme Dargent; Germany - Dr. Rudolf Weiner; Greece - Dr. John Melissas; Hungary - Dr. Jnos Bende; Israel Dr. Ilan Charuzi; Italy - Dr. Nicola Scopinaro; Japan - Dr. Isao Kawamura; Mexico - Dr. Ariel Ortiz Lagardere and Dr. Rafael Alvarez-Cordero; Netherlands - Dr. Jan Greve; Panama - Dr. Csar A. De Len Poblete; Poland - Dr. Marian Pardela; Russia Dr.Yury I.Yashkov; Spain - Dr. Aniceto Baltasar; Sweden - Dr. Erik Nslund; Switzerland - Dr. Andreas Glattli; Turkey - Dr. Mustafa Taskin; Ukraine - Dr. Andriy S. Lavryk; United Kingdom - Dr. John N. Baxter; and USA/Canada - Ms. Georgeann Mallory.
References
70% 65.11%
60%
50%
40%
30%
24.41%
10%
0% Gastric Bypass (Standard and LongLimb) Gastric Banding Vertical banded Gastroplasty Biliopancreatic Diversion/Duodenal Switch
1. Deitel M. Overweight and obesity worldwide now estimated to involve 1.7 billion people (Editorial). Obes Surg 2003; 13: 329-30. 2. Professor Philip James, Chair of the London-based International Obesity Task Force, Monte Carlo, March 17, 2003. Available at: http://www.iotf.org/media 3. Worldwatch Institute. Available at: http://www.worldwatch.org. Accessed September 9, 2002. 4. Flegal KM, Carroll MD, Kuczmarski RJ et al. Overweight and obesity in the United States: prevaObesity Surgery, 14, 2004
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Buchwald et al lence and trends, 1960-1994. Int J Obes 1998; 22: 3947. Mokdad AH, Serdula MK, Dietz WH et al. The spread of the obesity epidemic in the United States, 19911998. JAMA 1999; 282: 1519-22. Monteforte MJ, Torkelson CM. Bariatric surgery for morbid obesity. Obes Surg 2000; 10: 391-401. The National Center for Health Statistics NHANES IV Report. Available at: http://www.cdc.gov/nchs/product/pubs/pubd/hestats/obes/obese99.htm2002. Accessed September 9, 2002. World Health Organization Reports. [online] 2002. Available at: http://www.who.ch/ Accessed September 9, 2002. Gastrointestinal surgery for severe obesity. National Institutes of Health Consensus Development Conference Draft Statement. Obes Surg 1991; 1: 25766. 10.World Health Report 2002. Available at: www.iotf.org www.who.int/peh/burden/globalestim.htm. Accessed January 13, 2004. 11.Scopinaro N. The IFSO and obesity surgery throughout the world. Obes Surg 1998; 8: 3-8. 12.Angrisani L, Alkilani M, Basso N et al. Laparoscopic Italian experience with the Lap-Band. Obes Surg 2001; 11: 307-10. 13.Buchwald H. Mainstreaming bariatric surgery. Presidential Address, ASBS. Obes Surg 1999; 9: 46270. 14.Buchwald H, Buchwald JN. Evolution of operative procedures for the management of morbid obesity 1950-2000. Obes Surg 2002; 12: 705-17. (Received July 21, 2004; accepted August 5, 2004)
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