SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006

Revision Date 21.05.2010

The Safety Data Sheets for catalog items are also available at www.merck-chemicals.com
Page 1 of 9
1. Identification of the substance/mixture and of the company/undertaking
Product Information
Catalogue No.: 108325
Product name: Toluene for analysis EMSURE ACS,ISO,Reag. Ph Eur
Use of the
Substance/Mixture
Reagent for analysis, Solvent, Pharmaceutical production and analysis

Company: Merck KGaA * 64271 Darmstadt * Germany * Phone:+49 6151 72-0
Emergency telephone: Please contact the regional Merck representation in your country.
Responsible/issuing person: EQ-EPS * e-mail: prodsafe@merck.de

2. Hazards identification
GHS Classification
Flammable liquid, Category 2 H225: Highly flammable liquid and vapour.
Reproductive toxicity, Category 2 H361d: Suspected of damaging the unborn child.
Aspiration hazard, Category 1 H304: May be fatal if swallowed and enters
airways.
Specific target organ toxicity - repeated
exposure, Category 2
H373: May cause damage to organs through
prolonged or repeated exposure.
Skin irritation, Category 2 H315: Causes skin irritation.
Specific target organ toxicity - single exposure,
Category 3
H336: May cause drowsiness or dizziness.
EC Classification
F; R11
Repr.Cat.3; R63
Xn; R48/20 - 65
Xi; R38
For the full text of the R-phrases mentioned in this Section, see Section 16.

3. Composition/information on ingredients
Formula CHCH CH (Hill)
CAS-No. 108-88-3
Index-No. 601-021-00-3
EC-No. 203-625-9
Molar mass 92,14 g/mol

4. First aid measures

After inhalation: fresh air. If breathing stops: mouth-to-mouth respiration or mechanical
ventilation. Oxygen mask if necessary! Immediately call in physician.

After skin contact: wash off with plenty of water. Remove contaminated clothing.

After eye contact: rinse out with plenty of water. Call in ophthalmologist.

Safety Data Sheet
according to Regulation (EC) No. 1907/2006

Catalogue No.: 108325
Product name: Toluene for analysis EMSURE ACS,ISO,Reag. Ph Eur

The Safety Data Sheets for catalog items are also available at www.merck-chemicals.com
Page 2 of 9
After swallowing: caution if victim vomits. Risk of aspiration! Keep airways free. Call a physician
immediately. In case of spontaneous vomiting: Risk of aspiration. Pulmonary failure possible.
Call in physician.

5. Fire-fighting measures

Suitable extinguishing media
Carbon dioxide (CO2), Foam, powder, Dry powder

Specific hazards during fire fighting
Combustible material
Vapours are heavier than air and may spread along floors.
Forms explosive mixtures with air at ambient temperatures.
Pay attention to flashback.
Development of hazardous combustion gases or vapours possible in the event of fire.

Special protective equipment for fire-fighters
Do not stay in dangerous zone without self-contained breathing apparatus. In order to
avoid contact with skin, keep a safety distance and wear suitable protective clothing.

Further information
Prevent fire extinguishing water from contaminating surface water or the ground water system.
Cool closed containers exposed to fire with water spray.

6. Accidental release measures

Personal precautions
Do not breathe vapours, aerosols. Avoid substance contact. Ensure adequate ventilation.

Environmental precautions
Do not empty into drains. Explosive properties

Methods for cleaning up
Take up with liquid-absorbent material (e.g. Chemizorb ). Forward for disposal. Clean up
affected area.

7. Handling and storage
Handling

Advice on safe handling
Work under hood. Do not inhale substance. Avoid generation of vapours/aerosols.

Advice on protection against fire and explosion
Keep away from open flames, hot surfaces and sources of ignition. Take precautionary
measures against static discharge.

Storage

Further information on storage conditions
Keep away from heat and sources of ignition. Keep container tightly closed in a dry and well-
ventilated place.

Store at +15C to +25C.
Safety Data Sheet
according to Regulation (EC) No. 1907/2006

Catalogue No.: 108325
Product name: Toluene for analysis EMSURE ACS,ISO,Reag. Ph Eur

The Safety Data Sheets for catalog items are also available at www.merck-chemicals.com
Page 3 of 9

8. Exposure controls/personal protection

Personal protective equipment
Protective clothing should be selected specifically for the working place, depending on
concentration and quantity of the hazardous substances handled. The resistance of the
protective clothing to chemicals should be ascertained with the respective supplier.

Respiratory protection
required when vapours/aerosols are generated.
Recommended Filter type: Filter A (acc. to DIN 3181) for vapours of organic compounds

Hand protection
full contact:
Glove material: Viton (R)
Glove thickness: 0,70 mm
Break through time: > 480 min
splash contact:
Glove material: Nitrile rubber
Glove thickness: 0,40 mm
Break through time: > 10 min

The protective gloves to be used must comply with the specifications of EC irective 89/686/EEC
and he resultant standard EN374, for example. KCL 890 Vitoject (full contact), KCL 730
Camatril -Velours (splash contact).
The breakthrough times stated above were determined by KCL in laboratory tests acc. to
EN374 with samples of the recommended glove types.
This recommendation applies only to the product stated in the safety data sheet and supplied by
us as well as to the purpose specified by us. When dissolving in or mixing with other substances
and under conditions deviating from those stated in EN374 please contact the supplier of CE-
approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).

Eye protection
Safety glasses

Protective measures
Flame retardant antistatic protective clothing

Hygiene measures
Immediately change contaminated clothing. Apply skin- protective barrier cream. Wash hands
and face after working with substance. Work under hood. Do not inhale substance.

9. Physical and chemical properties
Form liquid

Colour colourless

Odour characteristic

pH not applicable

Viscosity, dynamic 0,6 mPa.s
at 20 C

Safety Data Sheet
according to Regulation (EC) No. 1907/2006

Catalogue No.: 108325
Product name: Toluene for analysis EMSURE ACS,ISO,Reag. Ph Eur

The Safety Data Sheets for catalog items are also available at www.merck-chemicals.com
Page 4 of 9
Viscosity, kinematic 0,7 mm2/s
at 20 C

Melting point -95 C

Boiling point/boiling range 110,6 C

Ignition temperature 535 C
Method: DIN 51794

Flash point 4 C
Method: c.c.

Oxidizing properties no data available

Flammability no data available

Lower explosion limit 1,2 %(V)

Upper explosion limit 8 %(V)

Vapour pressure 29 hPa
at 20 C

Relative vapour density 3,18

Density 0,87 g/cm3
at 20 C

Solubility/qualitative no data available

Water solubility 0,52 g/l
at 20 C

Partition coefficient: n-
octanol/water
log Pow: 2,65
Method: (experimental)
(IUCLID) No appreciable bioaccumulation potential is to be
expected (log Pow 1-3).
Evaporation rate no data available


10. Stability and reactivity

Conditions to avoid
Warming. A range from approx. 15 Kelvin below the flash point is to be rated as critical.

Materials to avoid
Risk of explosion with:

fuming sulfuric acid, Nitric acid, silver, perchlorates, nitrogen dioxide, nonmetallic halides, acetic
acid, halogen-halogen compounds, uranium hexafluoride, organic nitro compounds

Violent reactions possible with:

Strong oxidizing agents, Strong acids, sulfur, Heat.

Safety Data Sheet
according to Regulation (EC) No. 1907/2006

Catalogue No.: 108325
Product name: Toluene for analysis EMSURE ACS,ISO,Reag. Ph Eur

The Safety Data Sheets for catalog items are also available at www.merck-chemicals.com
Page 5 of 9
Hazardous decomposition products
no information available

Further information
unsuitable working materials:
various plastics, rubber
Vapours may form explosive mixture with air.

11. Toxicological information

Acute oral toxicity
LD50 rat
Dose: 636 mg/kg
(IUCLID)
Symptoms: Nausea, Vomiting, Risk of aspiration upon vomiting., Aspiration may cause
pulmonary oedema and pneumonitis., Pulmonary failure possible after aspiration of vomit.
Acute inhalation toxicity
LC50 rat
Dose: 28,1 mg/l, 4 h
(IUCLID)
Symptoms: Irritation symptoms in the respiratory tract., Headache, Drowsiness, drowziness,
Dizziness, After uptake of large quantities:, Pneumonia, respiratory paralysis
absorption

Acute dermal toxicity
LD50 rabbit
Dose: 12.124 mg/kg
(IUCLID)

absorption

Skin irritation
rabbit
Result: Irritations
Method: OECD Test Guideline 404
Repeated or prolonged exposure may cause skin irritation and dermatitis, due to degreasing
properties of the product.
Causes skin irritation.
Eye irritation
rabbit
Result: Eye irritation
Method: OECD Test Guideline 405
Specific target organ toxicity - repeated exposure
May cause damage to organs through prolonged or repeated exposure.

Genotoxicity in vitro
Mutagenicity (mammal cell test): micronucleus.
Result: negative
(IUCLID)
Ames test
Result: negative
(Lit.)
Safety Data Sheet
according to Regulation (EC) No. 1907/2006

Catalogue No.: 108325
Product name: Toluene for analysis EMSURE ACS,ISO,Reag. Ph Eur

The Safety Data Sheets for catalog items are also available at www.merck-chemicals.com
Page 6 of 9
CMR effects
Teratogenicity:
Suspected of damaging the unborn child.

Further information
Systemic effects:
After absorption of large quantities:
CNS disorders, inebriation, Convulsions, Unconsciousness, respiratory arrest, Circulatory
collapse, death
Further toxicological data:
Handle in accordance with good industrial hygiene and safety practice.

12. Ecological information
Ecotoxicity

Toxicity to fish
LC50
Species: Oncorhynchus mykiss (rainbow trout)
Dose: 5,8 mg/l
Exposure time: 96 h
(ECOTOX Database)
Toxicity to daphnia and other aquatic invertebrates.
EC50
Species: Daphnia magna (Water flea)
Dose: 6 mg/l
Exposure time: 48 h
(ECOTOX Database)
NOEC
Species: E.sulcatum
Dose: 456 mg/l
Exposure time: 72 h
(IUCLID)
Toxicity to algae
IC50
Species: Pseudokirchneriella subcapitata (green algae)
Dose: 12 mg/l
Exposure time: 72 h
(Lit.)
Toxicity to bacteria
EC50
Species: Photobacterium phosphoreum
Dose: 20 mg/l
Exposure time: 30 min
(Lit.)
Mobility
Henry constant
683Pa*m3/mol
(Lit.) Distribution preferentially in air.

Safety Data Sheet
according to Regulation (EC) No. 1907/2006

Catalogue No.: 108325
Product name: Toluene for analysis EMSURE ACS,ISO,Reag. Ph Eur

The Safety Data Sheets for catalog items are also available at www.merck-chemicals.com
Page 7 of 9
Theoretical oxygen demand (ThOD)
3.130 mg/g
(Lit.)
Partition coefficient: n-octanol/water
log Pow: 2,65
Method: (experimental)
(IUCLID) No appreciable bioaccumulation potential is to be expected (log Pow 1-3).
Additional ecological information
Biological effects:
Change in the flavour characteristics of fish protein.
Further information on ecology
Do not allow to enter waters, waste water, or soil!

13. Disposal considerations

Product
Chemicals must be disposed of in compliance with the respective national regulations. Under
www.retrologistik.de you will find country- and substance-specific information as well as contact
partners.
Packaging
Merck product packaging must be disposed of in compliance with the country-specific
regulations or must be passed to a packaging return system. Under www.retrologistik.de you will
find special information on the respective national conditions as well as contact partners.

14. Transport information
ADR/RID
UN 1294 TOLUENE, 3, II
IATA
UN 1294 TOLUENE, 3, II
IMDG
UN 1294 TOLUENE, 3, II
EmS F-E S-D
The transport regulations re cited according to international regulations and in the form applicable
in Germany. Possible national deviations in other countries are not considered.


15. Regulatory information
GHS-Labelling
Hazard pictograms


Signal word
Danger

Hazard statements
H225: Highly flammable liquid and vapour.
Safety Data Sheet
according to Regulation (EC) No. 1907/2006

Catalogue No.: 108325
Product name: Toluene for analysis EMSURE ACS,ISO,Reag. Ph Eur

The Safety Data Sheets for catalog items are also available at www.merck-chemicals.com
Page 8 of 9
H304: May be fatal if swallowed and enters airways.
H361: Suspected of damaging fertility or the unborn child.
H373: May cause damage to organs through prolonged or repeated exposure.
H315: Causes skin irritation.
H336: May cause drowsiness or dizziness.

Precautionary statements
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P301 + P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P331: Do NOT induce vomiting.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.

Reduced labelling (125 ml)
Hazard pictograms


Signal word
Danger

Hazard statements
H304: May be fatal if swallowed and enters airways.
H361: Suspected of damaging fertility or the unborn child.

Precautionary statements
P301 + P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.


Index-No. 601-021-00-3
Labelling according to EC Directives
Symbol(s): F
Xn
Highly flammable
Harmful
R-phrase(s): 11-38-48/20-63-65-
67
Highly flammable. Irritating to skin. Harmful: danger of
serious damage to health by prolonged exposure
through inhalation. Possible risk of harm to the unborn
child. Harmful: may cause lung damage if swallowed.
Vapours may cause drowsiness and dizziness.
S-phrase(s): 36/37-46-62 Wear suitable protective clothing and gloves. If
swallowed, seek medical advice immediately and show
this container or label. If swallowed, do not induce
vomiting: seek medical advice immediately and show
this container or label.

EC-No. 203-625-9 EC Label
Reduced labelling (125 ml)
Symbol(s): F
Xn
Highly flammable
Harmful
R-phrase(s): 48/20-63-65 Harmful: danger of serious damage to health by prolonged exposure
through inhalation. Possible risk of harm to the unborn child. Harmful:
may cause lung damage if swallowed.
S-phrase(s): 36/37-62 Wear suitable protective clothing and gloves. If swallowed, do not
induce vomiting: seek medical advice immediately and show this
container or label.

EC Label


Safety Data Sheet
according to Regulation (EC) No. 1907/2006

Catalogue No.: 108325
Product name: Toluene for analysis EMSURE ACS,ISO,Reag. Ph Eur

The Safety Data Sheets for catalog items are also available at www.merck-chemicals.com
Page 9 of 9
National legislation
Storage class VCI: 3 Flammable Liquids

Major Accident Hazard
Legislation:
96/82/EC Update: 2003
Highly flammable
7b
Quantity 1: 5.000 t
Quantity 2: 50.000 t

Other regulations: Take note of Dir 94/33/EC on the protection of young people at
work. Take note of Dir 92/85/EEC on the safety and health at work
of pregnant workers.

16. Other information
Full text of R-phrases referred to under sections 2 and 3
R11 Highly flammable.
R38 Irritating to skin.
R48/20 Harmful: danger of serious damage to health by prolonged
exposure through inhalation.
R63 Possible risk of harm to the unborn child.
R65 Harmful: may cause lung damage if swallowed.

Regional representation: This information is given on the authorised Safety Data Sheet for
your country.


The information contained herein is based on the present state of our knowledge. It characterizes the product with
regard to the appropriate safety precautions. It does not represent a guarantee of the properties of the product.