Brand Name: Prevacid

Generic Name: Lansoprazole

Indications: Erosive esophagitis, duodenal ulcers, active benign gastric ulcer, short-term
treatment of symptomatic GERD, healing and risk reduction of NSAID-
associated gastric ulcer, Pathologic hypersecretory conditiond, including
Zollinger-Ellison syndrome.
Drug Classification: Antiulcer agents, proton-pump inhibitors
Mechanism of Action: Binds to an enzyme in the presence of acidic gastric pH,
preventing the final transport of hydrogen ions into the gastric lumen.
Therapeutic effect: Diminished accumulation of acid in the gastric lumen,
with lessened acid reflux.
Dosage: Adult: Short-term treatment of duodenal ulcer – 15 mg od for 4 wks;
maintenance of healed duodenal ulcers – 15 mg od; short-term treatment of
gastric ulcers/healing of NSAID-associated gastric ulcer – 15 mg od for up
to 12 wks; short-term treatment of symptomatic GERD – 15 mg od for up to
8 wk.
Special Precautions: Geriatric patients; severe hepatic impairment; pregnancy, lactation,
or children < 1 yr.
Pregnancy Risk Category: B
Adverse Reactions:
CNS: headache, dizziness
GI: abdominal pain, diarrhea, nausea
Derm: rash.
Contraindications: Hypersensitivity
Forms: Delayed-release capsules – 15 mg, 30 mg; Solutabs – 15 mg, 30 mg; Delayed-
release oral suspension packets – 15 mg, 30 mg
Nursing Responsibilities:
 Assess patient routinely for epigastric or abdominal pain and for frank
or occult blood in stool, emesis, or gastric aspirate.
 Administer before meals. Capsules may be opened and sprinkled on 1
tbsp of applesauce, pudding, cottage cheese, or yogurt and swallowed
immediately for patients with difficulty swallowing. Do not crush or
chew capsule contents
Advise patient to avoid alcohol, products containing aspirin, or NSAIDs, and foods that
may cause an increase in GI irritation.