Brand Name: Zegen

Generic Name: Cefuroxime

Indications: Treatment of bone and joint infections, bronchitis (and other lower
respiratory tract infections), gonorrhea, meningitis, otitis media, peritonitis,
pharyngitis, sinusitis, skin infections, surgical infections and UTI.
Drug Classification: Antibiotics
Mechanism of Action: Bind to bacterial cell wall membrane which causes cell death.
Dosage: Cap Adult and children > 10 y/o 250-500mg q8h, Inj Adult 750mg-1.5g every 6-
8 hrs for 5-10 days. Children > 3 months 50-100 mg/kg body wt/day in equally
divided doses every 6-8 hrs.
Special Precaution: Hypersensitivity to penicillins. Possible superinfection in prolonged
use. Nephrotoxicity and ototxicity.
Pregnancy Risk: B
Adverse Reaction: Thrombophlebitis, Pruritus, urticaria, +ve Coombs’s test, diarrhea,
nausea, pseudomembrenous colitis,. Decrease in Hb and hematocrit transient
increase in liver enzymes, elevation in serum creatinine and BUN. Possible
seizure and angiodema.
Contraindications: Known allergy to cephalosporins.
Form: Capsule and inj.
Nursing Responsibilities:
 Assess patient fro infection at the beginning and during the therapy.
 Before initiating thepary, obtain a history to determine previous use of and
reaction to penicillin or cephalosporins. Person with a negative history of
penicillin sensitivity may still have an allergic response.
 Obtain specimens for culture and sensitivity before initiating the therapy.
 Observe patient for sings and symptoms of anaphylaxis (rash, pruritus, laryngeal
edema, wheezing)
 Assess patient for renal dysfunction and adjust accordingly.