NEW TEST SERIES - V

Duration: 2.00 hours 100 Max Marks:

1. 2. 3. 4. 5. 6. 7.

This question paper contains 50 objective type questions. Q. 1 to 40 carry 2 marks each. Q. 41and 50 are common data based question, each carry two marks. In case of wrong answer 0.5 marks will be deducted. Using HP pencil, darken the appropriate double under each digit of your registration number and the letters corresponding to your paper code. Calculator is allowed in the examination hall. charts, graph sheets or tables are NOT allowed in the examination hall Rough work can be done on the question paper itself. Additionally blank pages are given at the end of the question paper for work.

Sunil mokati

CENTRE - LIC BUILDING, 3rd FLOOR, CIVIL LINES, SAGAR (M.P.) Mob.: 9753030576, 9907039445, 9981779766

NEW TEST SERIES-V

1. 2. 3. 4. 5. 6. Polarography technique is based on the measurement of (a) Potential difference (b) Resistance a (c) Tempreture change (d) Conductivity Which of the following is used as suspending agent in parental product (a) Polysorbate 20 (b) Thiomersal (c) Na CMC a (d) Mannitol The polymer which have highest water and gas permeation is (a) Polyamide (b) Polystyrene a (c) Polypropylene (d) Polycarbonate In conductometry the specific conductance of solution is equal to a) cell constant / specific resistance (b) cell constant / resistance a (c) specific resistance / cell constant (d) resistance / cell constant Loss of taste sensation can be a side effect of the following antihypertensive drug (a) Clonidine (b) Captopril a (c) Verapamil (d) Prazosin The principle action common to all class I antiarrythmic drugs is (a) Na+ channel blockade a (b) K+ channel opening (c) Depression of effective refractory (d) Mild lipophilic period Most frequently used non aqueous water immiscible solvent for parentral (a) Dimethyl acetamide (b) N-lactamide (c) Benzyl benzoate a (d) Propylene glycol Pyrogens are the metabolic products of (a) Gram-ve bacteria a (b) Gram+ve bacteria (c) Viruses (d). BGA Diffusion current is directly propotinal to (a) Concentration of substance being oxidized or reduced (b) Natureof substance being oxidized or reduced a (c) Both (d) None For calomel electrode,the connection to the test solution is made through (a) HCL (b) KCL a (c) AgCl (d) Hg2Cl2 Glass membrane electrode at very low H+ concentration (pH>9.0) respond to alkali metal ions with the H- ion it is known as (a) Hydrogen ion error (b) Alkaline error a (c) Matrix effect (d) Background error The following antihypertensive drug has favourable effect on plasma lipid profile (a) Prazosine a (b) Propanolol (c) hydrachlorothiazide (d) furosemide Choose the drug that selactivily block AT1 sub type of angiotensin receptors (a) Ramipril (b) Candesartan a (c) Lovastatin (d) Sumatriptan Long term hydralazine tharpy is likely to cause (a) Gynacomastia (b) Thromocytopenia (c) Haemolytic anaemia (d) Lupus erythematosus a Which of the following statement is not correct (a) Hydralazine dilate mainly resistance (b) Nitrate dilate mainly capacitance vessels 2

7. 8. 9.

10. 11.

12. 13. 14. 15.

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16. 17. 18. 19. 20.

21.

22. 23. 24. 25. 26. 27. 28. 29.

30.

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vessels (c) Nicorandil dilate mainly capacitance (d) Losartane dilate both resistance and vessels a capacitance vessels In case of flurescence, lamination stop within (a) 10-8 to10-4 sec a (b) 10-4to10 sec (c) Both (d) None Process in which determination of EMF is carried out and steady state is maintained (a) Voltametry (b) Potentiometry (c) Amperometry a (d) All As indicator electrode used in potentiometry is basically made up of (a) Platinum (b) Zinc (c) Hydrogen (d) All a Which of the following drug does not require to become active form (a) enalapril (b) perindopril lisinopril a (d) benazeprile Migration current can be made zero by (a) Adding more amount of similar reducible (b) Adding indifferent electrolyte a agent (c) Keeping the solution as such for long (d) All time The nitrogen rule is often helpful in mass spectrometry which state that (a) A molecule of even numbered molecular mass must contain no nitrogen atom (b) A molecule of even numbered molecular mass must contain even no. of nitrogen atom (c) An odd numbered molecular mass requires an odd number of nitrogen atoms (d) all of the above a Desacetyle digilanide-A cardiac glycoside contain (a) Digitoxigenine a (b) Gitoxigenine (c) Oubagenine (d) Digoxigenine One characteristic not as critical for ophthalmics is freedom from (a) Pyrogens a (b) PH adjustment (c) Isotonicity adjustment (d) Purity The measurement of the intensity of transmitted light of a suspension is the basis of (a) Nephlometric analysis (b) Colorimetric analysis (c) Turbidimetric analysis (d) Both b and c a Large vials and bottles are made by (a) Glass tubing (b) Blow molding a (c) Both (d) None Which of the following drug is phenothiazine analogue (a) Mexiletine (b) Azimilide (c) Moricizine a (d) None Teflon liners have been applied on rubber closure to provide an effective barrier against (a) Sorption (b). Leaching (c) Vapour permeation (d) All a The following are the mass detector EXCEPT (a) Faraday cup detector (b) Electron detector (c) Photo detector a (d). Photographic detector Lyophilization is a process which is applicable to (a) Thermolabile substance a (b) Thermostable substance (c) Substance which unstable in (d) Substance which is unstable on freeze drying dry state When captopril given with allopurinol, there is increase in risk of (a) Hypersensitivity a (b) Lithium level (c) Blood level of captopril (d) All of them 3

31. 32. 33. 34.

35

36. 37. 38. 39. 40.

Instrumental methods of evaluation for particulate matter in liquids utilizing the principles of (a) Light scattering (b) Light absorption (c) Electrical resistance (d) All a Which of the following drug is endothelial antagonist (a) Beraprost (b) Hydralazine (c) Bosentan a (d) Sodium nitropruside Potassium channel agonistic drug are (a) Diazoxide (b) Minoxidile (c) Nicorandil (d) All of these a Nifedipine block (a) T-type voltage sensitive Ca++ channels (b) N-type voltage sensitive Ca++ channels ++ (c) L-type voltage sensitive Ca channels (d) T-type voltage sensitive Na++ channels a The peripheral vein may be considered a suitable route for intravenous administration in which of the following situations (a) When an irritating drug is given (b) When hypertonic drugs are given (c) For administering dextrose 15% as (d) For long term therapy parentral nutrition a Which one drug can block Na+, K+ and Ca++ channel (a) Propafenone (b) Flecainide (b) Dofetilide (d) Amiodarone a All the following are potential hazards of the parentral therapy EXCEPT (a) Hypothermia (b) Phlebitis (c) Extravasation (d) None a A inodilator are the drug which cause thrombocytopenia is (a) Sildenafil (b) Hydralazine (c) Inamrinone a (d) Minoxidil Which of the following is/are membrane stabilizing agent (a) Phenytoin a (b) Amiodarone (c) Dofetilide (d) Both b and c Which 1 blocker are uricoosuric in nature (a) Tamsulosin a (b) Prazosin (c) Temazosin (d) Doxazosin

LINKED QUESTION
41. 42. In which technique, the reagent gas is used (a) GS-MS (b) CI-MS a (c) GC-MS (d) DM-MS The above technique is used for certain compound which on fragmentation shows (a) Negative ions is more intense than (b) Positive ions is more intense than positive ions a Negative ions (c) Both are equal in proportion (d) All DATA FOR QUESTION 43-44 Suspension of solid have been used in the eye when the therapeutic need superseded the need to avoid irritating effect. The concentration of solid in ophthalmic suspension should be (a) Less than 5% a (b) Less than 10% (c) Less than 15% (d) Less than 20% All the following are used as preservatives in ophthalmics EXCEPT (a) Benzalkonium chloride (b) Phenol a (c) Phenyl mercuric acetate (d) Chlorobutanol

43. 44.

LINKED QUESTION
45.
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A novel antianginal drug which act via non haemodynamic mechanism. The drug is (a) Dipyridamol (b) Nicorandil 4

46.

47 48

(c) Trimetazidine a (d) Oxyphedrine The mechanism of above drug is (a) Inhibiting mitochondrial long chain 3- (b) Reducing fatty acid metabolism and KAT increase glucose metabolism (c) Protecting against O* free radical (d) All of the above a induced membrane damage DATA FOR 47 48 1,4 dihydro2,6-dimethyl -4-(2-nitrophenyl)-3,5-pyridine carboxylate is the IUPAC name of a drug which is used in vasospastic angina and classical angina pectoris. The drug is (a) Nisoldipine (b) Nimoldipine (c) Nifedipine a (d) Nicardipine The side effect of the above drug is (a) Increase urine voiding difficulty in males (b) Increase urine voiding difficulty in a females (c) Increase insulin level in males (d) Reduces hypotension

LINKED QUESTION
49. In the synthesis of diazoxide, the starting material is (a) 2,4-dichloronitrobenzene + benzylthiol a (b) (c) 2,6-diiodo-5-nitrobenzene + benzylthiol (d) If the drug is given at its therapeutic level. It causes (a) Hypertension (b) (c) Hypersensitivity (d) 2,4-diiodonitrobenzene + benzylthiol 2,6-dichloro-5-nitrobenzene diethylthiol Vasodepression Bronz skin a +

50.

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