Beruflich Dokumente
Kultur Dokumente
CMV Smallpox
OA
VZV
HIV/AIDS
Hepatitis B/C
Antiviral Drugs?
DNA This works ts well into the WAG Priority of Health and biosciences
Avian u H5N1
O
O
ganciclovir Cymevene CMV Roche
H C C
Br
N N
HN H2N N
N N
HN O HO N
BVDU Brivudin VZV Menarini
OH
O
d4T Stavudine HIV BMS
HN O HO
NH2
N N
abacavir Ziagen HIV GSK 3TC lamivudine HepB O GSK
N N O
N O
HO
Nucleoside Drugs
O
NH
Thymidine
HO O
OH
Nucleoside Drugs
O
NH
AZT
HO O
N3
Nucleoside Drugs
O
NH
HO O
NH2
OH
deoxyguanosine
Nucleoside Drugs
O
NH
HO O
NH2
acyclovir
Kinase Kinase
O OH O
a ct ive d4TTP
O P OH O O
O HN N O Me
Kinase
in
eO v i t ac
d4T
HO P O P O OH
d4TMP
The pre-formed phosphate (nucleotide) is of limited use as its charge prevents cell entry.
X
A blocked nucleotide or ProTide
ProTides
GB Patent appl. 9505025, Mar 13 1995 McGuigan, J Med Chem, 1996, 39, 1748 .
gemcitabine
NH2 N N O
MP (also TG)
S N N H N NH
FU
also capecitabine
O NH N H O
NH2 N N N F
HO O OH
NH2 N N N N Cl
cladribine
HO
cytarabine
NH2 N N O
udarabine
HO OH approved anti-cancer O
OH
OH
NH2
OH
OMe N N N NH2
clofarabine
HO O
N N N F
nelarabine
Cl
N HO O OH OH
OH
Working with Nucana BioMed we are applying ProTides to cancer nucleosides, such as Gemcitabine.
NH2 N N HO O OH F
Hugh S Griffith CEO