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P .7.f. Child and adolescent disorders and treatment Other (clinical) Serbia, India, Indonesia, Nigeria, Bulgaria, Croatia, and Turkey completed the Pediatric Quality of Life Inventory (PedsQL) for QOL assessments and Strengths and Difculties Questionnaire (SDQ) for mental health difculties. Assuming that the aspects of psychopathology and QOL could be highly inter-correlated due to similarities in items, the PedsQL items with similar meaning to the SDQ items measuring psychopathology were omitted. A SEM model was tested for this purpose: one latent QOL variable represented by three indicators scales derived from the PedsQL (Physical functioning, Social functioning, and School functioning) and two correlated predictors mental difculties (derived from the SDQ scores indicating signicant psychopathology) and chronic condition/illness (the presence/absence of a chronic health problem). The following statistics was used to assess the adequacy of the model: Tucker Lewis Index TLI (>0.95 excellent), the Comparative Fit Index CFI (>0.95 excellent), and Root Mean Square Error of Approximation RMSEA (<0.05 excellent). Results: In overall, data from 2367 adolescents [1184 males and 1183 females, mean age 15.64 (1.28) years] were available for this study. Of these, 212 (9%) adolescents showed signicant psychopathology as indicated by the SDQ. For the SEM model specied above, the t statistics indicated excellent model t, with TLI = 0.974, CFI = 0.990, RMSEA = 0.038. In the model, mental health difculties and chronic condition were signicant predictors of QOL, b = 0.28 (p < 0.05) and b = 0.05 (p < 0.05), respectively. Conclusions: Mental health signicantly inuence levels of QOL and it should to be considered routinely in QOL assessments among adolescents. Although preliminary, this data indicate that interventions targeting QOL might indirectly inuence mental health, but not only vice versa. The effects of different mental difculties such as internalizing and externalizing problems and QOL, as well as models invariance considering age, gender, and socioeconomic status, shall be evaluated.
References [1] Acquadro, C., Berzon, R., Dubois, D., et al., 2003 Incorporating the patients perspective into drug development and communication: an Ad Hoc Task Force report on the Patient-Reported Outcomes (PRO) Harmonization Group Meeting at the Food and Drug Administration, February 16, 2001. Value Health, 5, 522531. [2] Stevanovic, D., 2013 Impact of emotional and behavioral symptoms on quality of life in children and adolescents. Quality of life Research, 22, 333337. [3] Atilola O, Singh Balhara YP, Stevanovic D, et al., 2013 Self-reported Mental Health Problems among Adolescents in Developing Countries: Results from an International Pilot Sample. Journal of Developmental & Behavioral Pediatrics, 34, 129137.

Mean number of hours of sleep negatively correlated with PSS score (rp= 0.221; p = 0.000). Mean SDQ score was 12.045.01 (males: 11.484.90; females: 12.575.07; t = 3.986; p = 0.000). Signicant differences were observed by age (14 or less years: 11.424.76; 15 years: 12.884.86; 16 or more years: 12.345.23; F = 8.083; p = 0.000), the effect was exerted by individuals aged 1516, which had higher scores than younger students. Immigration status was not associated with SDQ (immigrants: 12.604.58; no-immigrants: 11.935.03; t = 1.25; p = 0.211). Mean hours of sleep was not correlated with SDQ prosocial scale but negatively correlated with all the other scales (p 0.008). Conclusions: This study supports the evidence that inadequate sleep is maybe associated with problematic psychosocial adjustment of youth. Poor sleep is positively correlated with higher PSS and SDQ scores. Since sleep problems are common among adolescents, also due to maturational processes and changes in sleep patterns, institutions dealing with the young should be aware and pay more attention to this problem, and implement preventive and intervention programs.

P.7.f. Child and adolescent disorders and treatment Other (clinical)

P.7.f.001 Relationships between psychopathology and quality of life among adolescents: a structural equation modeling approach D. Stevanovic1 , O. Atilola2 , Y.P. Singh Balhara3 , M. Avicenna4 , H. Kandemir5 , P. Vostanis6 , R. Knez7 , T. Franic8 , P. Petrov9 , Z. Vlaskalic1 1 General Hospital Sombor, Department of Psychiatry, Sombor, Serbia; 2 University College Hospital Ibadan, Department of Psychiatry, Ibadan, Nigeria; 3 All India Institute of Medical Sciences, Department of Psychiatry, New Delhi, India; 4 State Islamic University Syarif Hidayatullah, Faculty of Psychology, Jakarta, Indonesia; 5 Harran University, Department of Psychiatry, Sanliurfa, Turkey; 6 Leicester University, School of Psychology, Leicester, United Kingdom; 7 University Hospital Centre Rijeka, Department of Psychiatry, Rijeka, Croatia; 8 University of Split, Department of Psychiatry, Split, Croatia; 9 University Hospital St. Marina, Department of Child and Adolescent Psychiatry, Varna, Bulgaria Purpose: One of the main characteristics of measuring quality of life (QOL) in psychopharmacology is in providing data about the impacts of specic treatments on different aspects of well-being and functioning [1]. Therefore, QOL and other similar patientreported outcome (PRO) measures are recognized by regulatory bodies as important outcome measures in clinical trials, drugs registration, and marketing processes as an important target for intervention. Nevertheless, the aspects of psychopathology and QOL are highly inter-correlated and no clear demarcations were made the concepts [2]. As a useful method for studying complex relationships between various constructs, structural equation modeling (SEM) has not received much attention to study psychopathology and QOL together. This study evaluated the relationships between aspects of QOL and mental health using a SEM approach among adolescents in an international sample. >Methods: In this study, adolescents from an international project participated [2]. Adolescents aged 1418 years from

P.7.f.002 Association of latrophilin 3 gene polymorphism with behavioral problems in attention-decit/hyperactivity disorder K.H. Yook1 , H.J. Hong2 , J. Song3 1 Bundang CHA hospital School of medicine CHA University, Psychiatry, Seongnam, South-Korea; 2 College of Medicine Hallym University, Psychiatry, Anyang, South-Korea; 3 National Health Insurance Service Ilsan Hospital, Psychiatry, Goyang, South-Korea Purpose of the study: Genetic inuence on attention-decit/ hyperactivity disorder (ADHD) has been investigated in many researches. Recent study explored novel genes which are involved with ADHD beyond catecholamine system. Latrophilin 3 gene (LPHN3) is one of those novel genes and the association between