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HUBS1401
H Hydrogen (H)
O Oxygen (O)
N Nitrogen (N)
C Carbon (C)
Basic substance pH 7
Acid substance 7
Skin pH about 5
Blood pH about 7.4
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ATOMS AND CELLS
HUBS1401
BONDS
Ionic This chemical bond involves a transfer of an electron,
Bond so one atom gains an electron while one atom loses an electron.
One of the resulting ions carries a negative charge, and the other ion carries a positive
charge.
Because opposite charges attract, the atoms bond together to form a molecule
Covalent The most common bond in organic molecules, a covalent bond involves the sharing of
Bond electrons between two atoms.
The pair of shared electrons forms a new orbit that extends around the nuclei of both
atoms, producing a molecule.
Polar
Hydrogen
Polar Bond Two atoms connected by a covalent bond may exert different attractions for the
electrons in the bond, producing an unevenly distributed charge.
an intermediate case between ionic and covalent bonding, with one end of the
molecule slightly
Negatively charged and the other end slightly positively charged.
Resulting molecule is neutral; at close distances the uneven charge distribution can
be important. Water is an example of a polar molecule; the oxygen end has a slight
positive charge whereas the hydrogen ends are slightly negative.
Polarity explains why some substances dissolve readily in water and others do not.
Hydrogen Because they’re polarized, two adjacent H2O (water) molecules can form a linkage, where a
Bond (electronegative)
hydrogen atom of one H2O molecule is electro statically attracted to the (electropositive) oxygen
atom of an adjacent water molecule.
molecules of water join together transiently in a hydrogen-bonded lattice.
Hydrogen bonds have only about 1⁄20 the strength of a covalent bond, yet even this force is
sufficient to affect the structure of water, producing many of its unique properties, such as high
surface tension, specific heat, and heat of vaporization.
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ATOMS AND CELLS
HUBS1401
Several sub-categories
Monosaccharides
Disaccharides
Polysaccharides
Monosaccharides Monosaccharides, also called monomers or simple sugars, are the building blocks of larger
carbohydrate molecules and are a source of stored energy
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ATOMS AND CELLS
HUBS1401
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ATOMS AND CELLS
HUBS1401
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ATOMS AND CELLS
HUBS1401
Oxidation-Reduction
Important pair of reactions that occur in carbohydrates, lipid and protein metabolism
Oxidation and reduction occur together one oxidised, the other reduced
Electron This chemical reaction pairing to transport energy is a process known as the
transport chain respiratory chain or, electron transport chain
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ATOMS AND CELLS
HUBS1401
The Krebs Also known as the tricarboxylic acid cycle or citric acid cycle
Cycle This series of energy producing chemical reactions begins in the
mitochondria after pyruvate arrives from glycolysis.
Before the Krebs cycle can begin, the pyruvate loses a carbon dioxide
group to form acetyl coenzyme A (acetyl CoA).
Acetyl CoA combines with a four-carbon molecule (oxaloacetic acid,
or OAA) to form a six carbon citric acid molecule that then enters the
Krebs cycle.
The CoA is released intact to bind with another acetyl group. During
the conversion, two carbon atoms are lost as carbon dioxide and
energy is released.
One ATP molecule is produced each time an acetyl CoA molecule is
split.
The cycle goes through eight steps, rearranging the atoms of citric
acid to produce different intermediate molecules called keto acids.
The acetic acid is broken apart by carbon (or decarboxylated) and
oxidized, generating three molecules of NADH, one molecule of
FADH2 (flavin adenine dinucleotide), and one molecule of ATP.
The energy can be transported to the electron transport chain and
used to produce more molecules of ATP. OAA is regenerated to get
the next cycle going, and carbon dioxide produced during this cycle is
exhaled from the lungs.
Electron Series of energy compounds attached to the inner mitochondrial
Transport membrane
chain Molecules in the chain are called cytochromes
Electron transferring proteins contain a heme (iron group)
Hydrogen from oxidised food sources attach to coenzymes
combine with molecular oxygen
Energy produced is used to reattach inorganic phosphate groups to
ADP or ATP molecules
Pairs of electrons transferred to NAD produce three molecules of
ATP by oxidative phosphorylation after first phosphorylation
yield is only two ATP
Oxidative phosphorylation is important because it makes energy
available in a form cells can use
End of chain – two + charged hydrogen molecules combine with to
electrons and an atom of oxygen to form water
Final molecule to which electrons are passed is oxygen
Electrons are transferred from one molecule to the next, producing
ATP molecules.
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ATOMS AND CELLS
HUBS1401
Lactic Acid Severe soreness and fatigue in muscles after strenuous exercise is the
result of lactic acid build up during anaerobic respiration.
Glycolysis continues because it doesn’t need oxygen to take place.
Glycolysis does need a steady supply of NAD+, which usually comes from
the oxygen -dependent electron transport chain converting NADH back into
NAD+.
In its absence, the body begins a process called lactic acid fermentation, in
which one molecule of pyruvate combines with one molecule of NADH to
produce a molecule of NAD+ plus a molecule of the toxic by product lactic
acid.
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ATOMS AND CELLS
HUBS1401
The Cell
Cytology “Cyto” = cell, the study of cells
Selective permeability
Bilayer of phospholipids interspersed with protein molecules
Outer surface hydrophilic heads
Inside, between two layers, hydrophobic, non polar tails made up of fatty chains
Cholesterol molecules between phosphate layers add stability and make less permeable to
water soluble substances
Cytoplasm and the matrix where cells live are mainly water
Polar heads attract polarised water while non-polar tails lie between the layers, shielded
from water and creating dry middle layer
Membrane interior is made up of oily fatty acid molecules that are electro statically
symmetric or non polarised
Lipid soluble molecules can pass through oily fatty layer, but not water
Phospholipids also known as amphipathic molecules due to their polar and non-polar
regions
Cell membrane is designed to hold the cell together distinct functional unit of
protoplasm.
Can fix minor tears, but major damage will cause the cell to disintegrate
Allows some movement across cell membrane by diffusion, osmosis or active transport.
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ATOMS AND CELLS
HUBS1401
Diffusion
High Low
Facilitated diffusion – the cell membrane allows non polar molecules (don’t readily bond
with water) to flow from high to low concentration areas via channel proteins that create
diffusion friendly openings for molecules to diffuse through
Osmosis
Passive transport similar to diffusion solvent moving through semi permeable membrane
from higher lower concentration
Water is called universal solvent
Solvents are two parts
Water is a polar molecule small enough to pass through pores of most cell membranes,
but will not pass through lipid bilayer
Osmosis occurs where there is a different molecular concentration of water on the two sides
of the membrane solvent (water) is allowed to pass through but keeps out the particles
(solute) dissolved in the water
Osmolarity is the term used to describe concentration of solute particles per litre.
As water diffuses into a cell, hydrostatic pressure builds pressure becomes equal to and
balanced by the osmotic pressure outside.
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ATOMS AND CELLS
HUBS1401
Active Transport.
i.e. opposite of diffusion and osmosis – moves from LOW HIGH concentration gradient
Requires expenditure of energy released from ATP molecule
Protein molecules in the hydrophilic heads of the outer layer detect and move compounds
through the membrane
Carrier or transport proteins interact with passenger molecules and use ATP supplied energy
to move them against the gradient
Carrier molecules – usually amino acids and ions – combine with transport molecules to
pump them against the gradient
Active transport lets cells obtain nutrients that can’t pass through the membrane by other
means
Secondary active transport and processes that are similar to diffusion but instead use
imbalances in electrostatic forces to move molecules across the membrane.
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ATOMS AND CELLS
HUBS1401
Nucleus
Largest cellular organelle the first to be discovered by scientists accounts for about 10% of
the volume of the cell and holds a complete set of genes
Outermost part is the nuclear envelope phospholipid bilayer selectively permeable barrier
Inside phospholipid bilayer is the fluid filled space called the perinuclear cistema
Large pores in the barrier allow free movement in molecules and ions large protein molecules
included
Nuclear lamina intermediate filaments lining the surface of the envelope functions in the
disassembly and reassembly of the nuclear membrane during mitosis and bins the membrane in
the endoplasmic reticulum.
Nucleoplasm clear viscous material that forms the matrix in which the organelles of the nucleus
are imbedded.
Chromosomes contain DNA encoded with genetic information needed to direct cells activities
Nucleolus main subnuclear body sores RNA molecules ribosomes messenger RNA
(mRNA).
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ATOMS AND CELLS
HUBS1401
ORGANELLES AND THEIR FUNCTIONS (Part 1)
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ATOMS AND CELLS
HUBS1401
ORGANELLES AND THEIR FUNCTIONS (Part 2)
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ATOMS AND CELLS
HUBS1401
Cell Cycle – known also as CDC or cell division cycle.
Extends from the beginning of one cell division to the beginning of the next cell division
Two distinct phases
o Interphase – “resting phase”
Actively growing and carrying out normal metabolic function and preparing
for cell division.
o Mitosis
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ATOMS AND CELLS
HUBS1401
Prophase
o First active phase of mitosis
o Nucleus, nuclear membrane, nucleoplasm and nucleoli begin to disappear
o Centrioles push apart to opposite ends of the nucleus
o Form poles and mitotic spindle between them and asters radiate from the poles
into the cytoplasm
o Chromatin shorten and coil form chromosomes
o Chromosomes divide into chromatids and remain attached to centromere
o Tubules called kinetochre interact with spindle to ensure each daughter has full set
of chromosomes
o Start to migrate towards equatorial line, imaginary line between the poles
Metaphase
o Nucleus is gone
o Chromatids have lined up on equatorial line and attached to the mitotic spindle by
the centromere
Anaphase
o Centrosomes split separating duplicate chromatids and forming chromosomes
o Spindles shorten pulling chromosomes towards opposite poles
o Cell elongates
o Late anaphase cleavage furrow forms this is the site of cytokenisis.
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