HBY501 Physiology

Quiz #6, October 15, 2010

On the Scantron answer sheet, completely blacken the bubble (using a number 2 pencil) in the TEST FORM field indicating that this is test form A. Then, indicate your responses by filling in the bubble corresponding to the one lettered item that best answers each question or completes each statement. Correct responses are highlighted in red. 1. Which of the following is(are) NOT found in erythrocytes (RBCs)? A cytosolic enzymes involved in glycolysis B mitochondrial enzymes involved in oxidative metabolism C Na+,K+-ATPase (sodium pump) D carbonic anhydrase 2. Which of the following is NOT a dietary requirement for erythropoiesis? A vitamin K B folate (folic acid) C vitamin B12 (cobalamin) 3. The bulk of extracellular iron in plasma and interstitial fluid is in the form of A transferrin. B hemoglobin. C hepcidin.

D iron

D ferritin.

4. At the site of an injured vessel, platelets A adhere to exposed collagen. B degranulate and release the clotting factors. C degranulate and release a soluble factor required for activation of the clotting factors. D All of the above. 5. A patient suffering from hemophilia (either type A or B) exhibits excessive bleeding because A the common clotting pathway is nonfunctional. B the extrinsic clotting pathway is nonfunctional. C the intrinsic clotting pathway is nonfunctional. D the disorder causes thrombocytopenia (low platelet count). 6. A post-surgical patient is taking daily doses of warfaran (Coumadin) to prevent deep-vein thrombosis. On examination, you find that he has a low hematocrit, he complains of frequent nose bleeds, he bruises easily, and there is blood in his stools. Until the results of lab tests are available, the most prudent action to treat his bleeding disorder would be to A cease his warfaran doses, and administer large doses of heparin subcutaneously. B cease his warfaran doses, and administer large doses of vitamin K. C cease his warfaran doses, and transfuse him with platelets. D cease his warfaran doses, and administer large doses of erythropoietin. 7. Poiseuille's law states that blood flow through a tissue is A directly proportional to vessel length and directly proportional to blood viscosity. B inversely proportional to blood viscosity and inversely proportional to vessel (diameter)4. C directly proportional to vessel (diameter)4 and directly proportional to blood viscosity. D inversely proportional to peripheral resistance and directly proportional to mean arterial pressure The quiz continues on the back

8. The action potentials of sinoatrial-node (SA node) pacemaker cells A exhibit stable diastolic membrane potentials. B exhibit a decrease in the slope of diastolic depolarization phase during periods of sympathetic stimulation. C exhibit an unstable diastolic membrane potential that decreases in slope in response to an acetylcholineinduced change in K+ conductance. D exhibit a longer plateau phase than that observed in atrial cells. 9. Regarding the electrocardiogram (EKG), which of the following statements is TRUE? A A conduction block at the AV node will decrease the duration of the P-R segment. B The Q-T interval approximates the duration of the ventricular action potentials. C The QRS complex reflects ventricular repolarization and atrial depolarization. D The relative directions of the P, QRS and T waves reverse during vigorous exercise in a normal individual. 10. For one cardiac cycle that begins with an excitatory stimulus at the SA node, which temporal sequence is correct (steps may be missing)? (Note: mitral valve = left atrioventricular valve = bicuspid valve) A EKG QRS complex mitral valve closes isovolumetric contraction EKG T-wave aortic valve closes mitral valve opens B isovolumetric contraction opening of mitral valve isotonic contraction opening of aortic valve EKG-T wave C EKG P wave EKG T-wave ventricular volume decreases aortic valve closes D peak of intraventricular pressure first heart sound peak ejection velocity 11. With a mean electrical axis of the heart of 124o (consistent with a right axis shift), what would be the direction of the potentials noted on Einthoven leads I, II, and III? (Note: = positive deflection, = negative deflection, 0 = no net deflection.) A I = , II = 0, III = B I = , II = , III = C I = , II = , III = 0 D I = , II = 0, III = 12. Which of the following statements is FALSE? A The heart exhibits an inherent rate of contraction dictated by pacemaker cells in the heart, rather than pacemaker cells in the central nervous system. B Premature ventricular systole could occur if pacemaker cells in Purkinje fibers were to fire sometime during, or shortly after, the ventricular relative refractory period. C The heirarchy of firing frequency (fastest to slowest) of pacemaker cells is SA node > AV node > Bundle of His > Purkinje fibers. D If a stimulus originating from sympathetic nerve stimulation to the SA node were to occur during the relative refractory period of a ventricular action potential, then ventricular contraction will not occur. Did you remember to fill the A bubble in the Test Form field of your answer sheet?