You are on page 1of 26
SEPSIS OSTEOARTRITAE ENDOCARDITA TEGUM + TES MOI + ANTIBIOPROFILAXIA Strepto pyogen MENINGOCOC Strepto pneum-S Staf- meti-S

SEPSIS

OSTEOARTRITAE

ENDOCARDITA

TEGUM + TES MOI + ANTIBIOPROFILAXIA

Strepto pyogen MENINGOCOC Strepto pneum-S Staf- meti-S GONOCOC Staf –meti- R Enteroc faecium Clostridium spp -
Strepto pyogen
MENINGOCOC
Strepto pneum-S
Staf- meti-S
GONOCOC
Staf –meti- R
Enteroc faecium
Clostridium spp
-
Bacillus antrach

AMINO – PENICILINE

MENINGITA MENINGOCOCICA

PENICILINA G +

SEPSIS OSTEOARTRITAE ENDOCARDITA TEGUM + TES MOI + ANTIBIOPROFILAXIA Strepto pyogen MENINGOCOC Strepto pneum-S Staf- meti-S
 

Inf ORL

Endocardita

-

pneumococica

-

enterococica

-profilaxie

Enterococ fecalis Gonococ Enterococ faecium Stafilcoc Bacteroides Bordetella pertusis Vibrio cholerae Clostridium spp Bacillus antrach Haemophilus
Enterococ fecalis
Gonococ
Enterococ faecium
Stafilcoc
Bacteroides
Bordetella pertusis
Vibrio cholerae
Clostridium spp
Bacillus antrach
Haemophilus infl
non B si tip B
Enterobacterii
Fusobacterium

PNEUMONIE PNEUMOCOCICA PENI - I / S

SEPSIS OSTEOARTRITAE ENDOCARDITA TEGUM + TES MOI + ANTIBIOPROFILAXIA Strepto pyogen MENINGOCOC Strepto pneum-S Staf- meti-S

Infectii LISTERIA Alte infectii ENTEROCICE Boala LYME std I

PENICILINE NATURALE

ERIZIPEL ERIZIPELOID ROSENBACH SCARLATINA GANGRENA GAZOASA

PENICILINE NATURALE ERIZIPEL ERIZIPELOID ROSENBACH SCARLATINA GANGRENA GAZOASA RAA ANGINA - STREPTOCOCICA - PLAUT - VINCENT

RAA

ANGINA - STREPTOCOCICA - PLAUT - VINCENT

Peptostreptococ Streptococ pyogen Meningococ Enterococ faecium STAF Clostridium B –T- P difficile Actinomices israeli Bacillus anthracis
Peptostreptococ
Streptococ pyogen
Meningococ
Enterococ faecium
STAF
Clostridium B –T- P
difficile
Actinomices israeli
Bacillus anthracis
Fusobacterium necro.
Coryne diphterie
Pasteurella multoc
Bacteroides
Listeria
Erysipelothrix r.
Majorit BGN
PENICILINE NATURALE ERIZIPEL ERIZIPELOID ROSENBACH SCARLATINA GANGRENA GAZOASA RAA ANGINA - STREPTOCOCICA - PLAUT - VINCENT

SIFILIS

LEPTOSPIROZA INF ANAEROBI (Nu Bacteroides ) ACTINOMICOZA

SPIROCHETE : TREPONEMA spp LEPTOSPIRA BORELLIA spp SPIRILIUM

 

Mycoplasma

12. PROFILAXIA MUSCATURA ANIMAL

Chlamydia

Rickettsia

Mycobacterium spp

CARBOXIPENICILINE

CARBOXIPENICILINE Infectii BGN – mai ales piocianic in asoc cu AG AMINO – P + Pseudomona

Infectii BGN – mai ales piocianic in asoc cu AG

AMINO – P +

Pseudomona aerug Enterobacter Proteus – indol+ Morganella spp Serratia spp Providencia spp Alti vibrio
Pseudomona aerug
Enterobacter
Proteus – indol+
Morganella spp
Serratia spp
Providencia spp
Alti vibrio

Activitate mai ↓↓↓ decat AMPI pe: enterococi , streptococi , pneumococi (> 30 % ) Incidenta crescuta a BGN rezistenti la TICARCILINA : Enterobacter ,E. coli, Pseudomonas.

UREIDO-PENICILINE

MENINGITE cu BGN INF SISTEMICE cu germeni sensibili ANTIBIOPROFILAXIE chirurg colorectala / gineco
MENINGITE cu BGN
INF SISTEMICE
cu germeni sensibili
ANTIBIOPROFILAXIE
chirurg colorectala / gineco

AMINO – P +

STAF GONOCOC PNEUMO peni-R PSEUDOM aer BACTEROIDES ENTEROBAC sp . KLEBSIELA spp SERRATIA CITROBACTER H. INFLUENZ
STAF
GONOCOC
PNEUMO peni-R
PSEUDOM aer
BACTEROIDES
ENTEROBAC sp
.
KLEBSIELA spp
SERRATIA
CITROBACTER
H. INFLUENZ
Pseudomonas non
ACINETOBACT

Nu : - LISTERIA

  • - ENTEROCOCIS

  • - STAFILOCOC meti- R

  • - CLOSTRIDIUM difficile

CEFALOSPORINE

  • - MYCOPLASMA spp, CHLAMYDIA spp , RICKETTSIA spp

INF ORL comunitare INF bronsice comunitare INF cutanate ITU joase necomplicate
INF ORL comunitare
INF bronsice
comunitare
INF cutanate
ITU joase
necomplicate

Antibio-profilaxie

In chirurgie

CFS I

STREPTO PNEUMO peni-s/ peni R GONOCOC STAF meti- S ACTINOMYCES CORINEBACT E. coli difteriae PROTEUS mirA
STREPTO
PNEUMO peni-s/
peni R
GONOCOC
STAF meti- S
ACTINOMYCES
CORINEBACT
E.
coli
difteriae
PROTEUS mirA
BACTEROIDES spp
SALMONELLA
SHIGELLA
PASTEURELLA
H.
infl ß-lactamazo
negativi
ENTEROBACT
SERRATIA
CITROBACTER
PROVIDENCIA
MORGANELLA
CFS II
PROTEUS V.
PSEUDOMO
Alti
ACINETOBACT
Nu : - LISTERIA - ENTEROCOCIS - STAFILOCOC meti- R - CLOSTRIDIUM difficile CEFALOSPORINE - MYCOPLASMA

INF ORL comunitare

INF cutanate

parti moi

INF bronhopulmonare comunitare

Nu : - LISTERIA - ENTEROCOCIS - STAFILOCOC meti- R - CLOSTRIDIUM difficile CEFALOSPORINE - MYCOPLASMA

INF ginecologice

INF urinare

CFS I + BGN anaerobi

  • - activit superioara pe BGN aerobi

  • - rezistenta la ß - lactamaze

Antibio-profilaxie

in chirurgie

INF mixte aerobi si anaerobi pt cefamicine

CFS III

MENINGITE INF ORL INF RESPIRATORII INF PNEUMO -R INF CUTANATE PARTI MOI ENDOCARDITE ITU
MENINGITE
INF ORL
INF RESPIRATORII
INF PNEUMO -R
INF CUTANATE
PARTI MOI
ENDOCARDITE
ITU

GONOREE BOALA LYME FEBRA TIFOIDA ANTIBIOTICO- PROFILAXIE IN CHIRURGIE

STREPTO PNEUMO peni-S / MENIGOCOC Peni-R GONOCOC STAF meti- S MORAX catha ACTINOMYCES E. coli BACTEROIDES
STREPTO
PNEUMO peni-S /
MENIGOCOC
Peni-R
GONOCOC
STAF meti- S
MORAX catha
ACTINOMYCES
E.
coli
BACTEROIDES spp
PROTEUS mir,
vulgaris
SALMONELLA
SHIGELLA
PASTEURELLA
H.
influenzae
Providencia
Citrobacter
Klebsiella
Morganella
Borrellia burg.

ENTEROBACT

Citrobacter feund

SERRATIA

Yersinia

Klebsiella pneum

Pseudomonas aer

LEGIONELLA

ACINETOBACT

STENOTROFOMONAS MALTOPHILIA BURKOLDERIA CEPACIA

CFS spectru larg

CFS spectru larg Inf abdominale (+ metronidazol ) Inf de focar / sistemice – urinare, parti
CFS spectru larg Inf abdominale (+ metronidazol ) Inf de focar / sistemice – urinare, parti

Inf abdominale (+ metronidazol )

Inf de focar / sistemice – urinare, parti moi

Inf bacteriene severe la Ne- penici + AG

STREPTO PNEUMO peni-S / MENIGOCOC Peni-R GONOCOC STAF meti- S MORAX catha ACTINOMYCES E.coli Proeus mir,vulg
STREPTO
PNEUMO peni-S /
MENIGOCOC
Peni-R
GONOCOC
STAF meti- S
MORAX catha
ACTINOMYCES
E.coli
Proeus mir,vulg
Salmonella
Borrelia burgdorf
BACTEROIDES spp
Shigella
Enterobacter
Pasteurella
H. infl
Providencia
Piocianic
Serratia
Citrobacter
Klebsiella
Morganella

STENOTROFOMONAS MALTOPHILIA BURKOLDERIA CEPACIA

ACINETOBACT

Klebsiella pneum

Legionella

Spectru : CFS exrema stg + centru Activit superoara pe streptococi si piocianic (fata de CFS III ) Stabilit mai mare la act ß – lactaze cls I si ESBL- uri

ß-lactamine + IBL

AMOXI + IBL

ß-lactamine + IBL AMOXI + IBL INF ORL + stomatologice INF CUTANATE INF RESPIRATORII ITU si

INF ORL + stomatologice

INF CUTANATE

INF RESPIRATORII

ß-lactamine + IBL AMOXI + IBL INF ORL + stomatologice INF CUTANATE INF RESPIRATORII ITU si

ITU si genitale

INF prin muscaturi de

animal /om

AMOXI / AMPI + IBL

AMPI+ sulbactam

+ INF INTRAABDOMIMALE, PERITONITA

,peritonita

TICAR+ CLAVULANAT

+ BGN rezistenti la alte ßL

+ INF NEUTRIPENICI ( + alte AB)

PIPER+ tazobactam

CEFOPER+ sulbactam

+ inf SEVRE PLURIMICROBIENE cu germeni

multiR (+ piocianic)

+INF NEUTRIPENICI ( + alte AB)

TICARCILINA / PIPER + IBL

STREPTO PNEUMO peni-S / STREPTO PNEUMO peni-S / Peni-R si I peni I si R CGN
STREPTO
PNEUMO peni-S /
STREPTO
PNEUMO peni-S /
Peni-R si I
peni I si R
CGN
STAF meti- S
CGN
Enterococ faecium
STAF meti- S
Enterococ /
faecium
STAF -MR
STAF-MR
E.coli (piper)
E.coli
Klebsiella pneum
ACINETOBACTER
BACTEROIDES spp
BGP
Proteus
BGP
Salmonella
BACTEROIDES spp
E,coli (ticar )
Proteus
Salmonella
Shigella
Shigella
Enterobacter
Enterobacter
Pasteurella
Pasteurella
H. infl
H.
infl
Providencia
Campilobacter
Piocianic
Rezistenti : Chlamydia, Rickettsia,
V.
cholerae
ACINETOBACT
Mycobacterium
Capnocytophaga
Providencia
Serratia
Piocianic
Citrobacter
Serratia
Klebsiella
CARBAPENEME
Citrobacter
CGP
Morganella
Morganella
( enterococ
Yersinia
Klebsiella pneum
Legionella
/Faecium
CGN
Legionella
Nocardia
( moraxella )
MENINGITE , ABCESE CEREBRALE
STAF-metiR
b
l
STAF -MR
BACTEROIDES spp
BGP aerobi
( listeria)
7
INF RESPIRATORII ENDOCARDITE INF OSOASE INF ABDOMINALE INF URO-GENIT INF SEVERE LOCALIZATE / GENERALIZATE - germeni
INF RESPIRATORII ENDOCARDITE INF OSOASE INF ABDOMINALE INF URO-GENIT INF SEVERE LOCALIZATE / GENERALIZATE - germeni

INF RESPIRATORII

INF RESPIRATORII ENDOCARDITE INF OSOASE INF ABDOMINALE INF URO-GENIT INF SEVERE LOCALIZATE / GENERALIZATE - germeni

ENDOCARDITE

INF OSOASE

INF RESPIRATORII ENDOCARDITE INF OSOASE INF ABDOMINALE INF URO-GENIT INF SEVERE LOCALIZATE / GENERALIZATE - germeni

INF ABDOMINALE

INF URO-GENIT

INF SEVERE LOCALIZATE / GENERALIZATE

  • - germeni multirezistenti-

STARI FEBRILE LA NEUTROPENICI

BGN

Aer – si ana-

(piocianic)

Legionella

Citrobacter

jeikeium

ACINETOBACT

STENOTROFOMONAS MALTOPHILIA BURKOLDERIA CEPACIA MYCOPLASMA CHLAMYDIA RICKETTSIA MYCOBACTERIUM

GRUPUL MLSK Macrolide

ANGINE, + a.difterica IACRI -bronsite cr acutiz ACNEE -Pn Mycopl Chlamyd INF STAFILOCOCICE Legionella –ORL -cutanat
ANGINE, + a.difterica
IACRI
-bronsite cr acutiz
ACNEE
-Pn Mycopl
Chlamyd
INF STAFILOCOCICE
Legionella
–ORL
-cutanat
INF DIGESTIVE
-Cryptosporid
-Campylobacter
-Helicobater pylori
URETRITE
CERVICITE non-gonococ
PEPTOSTREPT MENINGO STAF MS / MR PNEUMOCOC STREPTOCOC moraxella c. GONOCOC E.faecium BORDETELLA BACTEROIDES HELICOBACT p
PEPTOSTREPT
MENINGO
STAF MS / MR
PNEUMOCOC
STREPTOCOC
moraxella c.
GONOCOC
E.faecium
BORDETELLA
BACTEROIDES
HELICOBACT p
FUSOBACTERIUM
B. anthracis
CAMPYLOBAC
CORIN.diphter
LEGIONELLA
LISTERIA
E.rhusiopathiae
H. inflUENZAE
RHODOCOC
VIBRIO
CLOSTRID perfr
ENTEROBA-CEE
NOCARDIA
PSEUDOMONSA
ACINETOBACT
  • - ERIZIPELOID

  • - TOXOPLASMA IN SARCINA

  • - TOXOPLASMA CEREBRALA

  • - Inf CU MAC

  • - ANGIOMATOZA BACILARA

  • - Alternativa la pac alergici la penicilina (sifilis, RAA)

LEPTOSPIRA spp

BORELLIA burgdorferi

TREPONEMA

MYCOPLASMA pn

CHLAMYDIA

UREAPLASMA U. RICKETSSIA BARTONELLA henselae

LINCOSAMIDE

INF

osteo-articulare

INF cavitatea bucala INF parti moi - INF cu ANAEROBI indifer de
INF
cavitatea bucala
INF
parti moi
-
INF cu ANAEROBI indifer de

localizare ( exceptie : meninge )

  • - Alte INF STAFILOCOCICE

PEPTOSTRPTO STAF MS / MR NEISSERIA PNEUMOCOC MORAXELLA STREPTOCOC ENTEROCOCI PREVOTELLA H.influenzae B. anthracis / cereus
PEPTOSTRPTO
STAF MS / MR
NEISSERIA
PNEUMOCOC
MORAXELLA
STREPTOCOC
ENTEROCOCI
PREVOTELLA
H.influenzae
B. anthracis / cereus
CORIN.diphter /
ENTEROBAC-CEE
BACTEROIDES
PSEUDOMONSA
jeikeium
PASTEURELAA
E.rhusiopathiae
FUSOBACTERIUM
LEGIONELLA
CLOSTRID perfr
ACTYNOMICES
EUBACTERIUM
CLOSTRID difficile
NOCARDIA
LISTERIA
  • - TOXOPLASMOZA CEREBRALA in SIDA ( + pirimetamina )

  • - INF ORL, PROFILAXIE ENDOCARDITA (alergici la peniciline/BL)

MYCOPLASMA hominis / pneumonie CHLAMYDIA trachomatis

UREAPLASMA U.

Clindamicina :

TOXOPLASMA gondii BABESIA microti PLASMODIUM spp PNEUMOCYSTIS carnii

AMINOGLICOZIDE

gen I

-

KANA

 

-

STREPTO

TBC, pesta,

 

tularemie, bruceloza,

inf enterococica

-

SPECTINO

uretrita gonococica

-

NEOMICINA→ decontam tub dig preoperator

 

coma hepatica,

otite ext

-

PAROMOMICINA

KANA ( nerecomandata in prezent)

-

CGP (pneumococ)

-

CGN

 

-

BGN

 

H. infl

Serratia

Morganella

Klebsiella

E.coli

Yersinia

Vibrio cholerae

treponeme

Br cella

 

gen III

-

AMIKA

 

-

NETILMICINA

-

ISEPAMICINA

-

DIBEKAMICINA

AMIKA, ISEPA

 

Spectru KANA +

 

LISTERIA

ACINETOBACTER

CITROBACTER

PIOCIANIC

PROVIDENCIA

AEROMONAS

MYCOBACTERII ATIPICE

+ / - PNEUMOCOC

Indicatii :

 
 

INF SEVERE germeni multirezist

 

+ BL

/FQ / GP

 

TBC germeni multiR

INF mycobacterii atipice

NETILMICINA, DIBEKA

 

~ GENTA

 

gen II

  • - GENTA

  • - TOBRAMICINA

  • - SISOMICINA

Spectru : AMIKA fara

PSUEDOMONAS

ACINETOBACTER (exceptie TOBRA)

MYCOBACTERII

Indicatii:

ENDOCARDITE INF(+ BL, VANCO)

INF SEVERE loc /gen cu STAF

INF URINARE

INF cu LISTERIA ( + aminoP)

Rezistenti :

Anaerobi

Pneumococ

STAF meti-R

Germeni intracelulari

Leptospire

Mecanism : fix pe subunit 30S ribozomala → inhiba sinteza

proteinelor

  • - Concentrare masiva intrabacteriana : permeabiliz, transport

activ dep de metabolismul aerob

  • - Bactericide, conc-dependente

  • - Efect post-antibiotic

  • - Doza unica, zilnica

Mecanism rezistenta:

enzimatic

impermeabilitate

mutatii tinta

Cele mai vechi : mai putin active

GENTA : mai activa pe Serratia, Bartonella

TOBRA: cea mai activa pe PIOCIANIC, ACINETOBACTER

AMIKA : Nocardia

CHINOLONE

CHINOLONE RESPIRATORII =

CHINOLONE URINARE

ANAEROBI CGP CGN E.COLI PROTEUS v si m ENTEROBACTER
ANAEROBI
CGP
CGN
E.COLI
PROTEUS v si m
ENTEROBACTER
CHINOLONE SISTEMICE + ANAEROBI NU Cl difficile STREPTO : - PYOGENES - VIRIDANS - PNEUMCOC +
CHINOLONE SISTEMICE +
ANAEROBI
NU Cl difficile
STREPTO :
-
PYOGENES
-
VIRIDANS
-
PNEUMCOC
+ /- MRSA

CHINOLONE SISTEMICE

Mecanism act: - act la niv enz ADN – giraza si topoizomeraza IV → inhiba sinteza
Mecanism act:
-
act la niv enz ADN – giraza si
topoizomeraza IV → inhiba sinteza
ANAEROBI
ADN
Bctericide
Conc-dependente
Efect postAB : 2 – 4 ore
STAF MS
NEISSERIA
STREPTO pyoge
MORAXELLA C.
STAF MRS
PNEUMOCOC
ENTEROCOC
ENTEROBACTERI
CAMPYLOBACT
NOCARDIA
LEGIONELLA
LISTERIA
VIBRIO spp
ACINETOBACT
PIOCIANIC

S : MICOBACTERII ATIPICE

R : UREAPLASMA urealyticum

anaerobi

Absorbtie digestiva : foarte buna

CHINOLONE SISTEMICE / RESPIRATORII

1. MENINGITE PURULENTE SECUNDARE + CFS III 2.OCULAR Q respiratorii 7. Acutizari bronsite cronice Q respiratorii
1. MENINGITE PURULENTE SECUNDARE + CFS III
2.OCULAR
Q respiratorii
7. Acutizari bronsite cronice
Q respiratorii
Pneumonii :
3.ORL : sinuzite, otite
- comunitare /nosocomiale
8. OSTEOARTICULAR
4.INF DIGESTIVE
+ lincosamide /RIFA
-febra tifoida
-dizenterie bact
-holera
-diaree calatori
5. INF urinare joase / inalte
6. INF GENITALE
-uretrite, prostatite
9. INF SISTEMICE
-gonoree
-salpingita
10.
ANTRAX
-boala inflam pelvina
-limfogranulomat veneriana benigna
11.
FEBRA Q
  • 12. INF MAC la pac HIV

  • 13. PROFILAXIE :

-portaj nazofaring

meningococ

-diaree calatori

Chinolone urinare

MEDICAMENT

DOZE

ADM

 

ADULT

COPIL

Ac nalidixic

30 – 50 mg/kg/zi

 

6 ore p.o.

NORFLOX

800 mg/zi

12 ore p.o.

LOMEFLOX

400 – 800 mg/zi

 

12 ore, p.o.

 

MEDICAMENT

DOZE

ADM

ADULT /zi

CIPRO

1 – 1.5 g -

po

12 ore

0.4 – 1.2 g - i.v.

PEFLOX

800 mg

12 ore; p.o / i.v.

OFLOX

400 – 800 mg

12 ore; p.o.

MOXI

400 mg

 

LEVO

500 mg

Priza unica ; p.o. / i.v.

GATI

400 mg

GEMI

320 mg

CICLINE

1.Inf genitale – Chlamydia

  • 2. Ricketssioze

-

febra Q

-

febra butonoasa

-

alte

  • 3. Holera

  • 4. Bruceloza

  • 5. boala Lyme

  • 6. Febra recurenta

  • 7. Inf cu

Mycobacterium fortuitum

  • 8. Ehrichioza

  • 9. Malarie

10.Inf cu Balantidium coli

Alternative pt :

1. Inf genitale – Chlamydia 2. Ricketssioze - febra Q - febra butonoasa - alte 3.

1.Pneumonii comunitare reduse / medii

2.Leptospiroza

3.Pasteurelloza

4.Inf digestive – dizenterie

5.Tularemie

6.Pesta

7.Inf cu –Mycoplasma pn / Ureaplasma u.

8.Boala Lyme ( cardita )

9.Inf cu Mycobacterium marinum

10.Acnee

11.

Actinomicoza

12.Antrax cutanat

13.Angiomatoza bacilara

14.

Nocardioza pulmonara

15.Sifilis

16.

Febra muscaturii de sobolan

17.

Malarie- profilaxie

PEPTOSTRPTOCOC PROPIONEBACTER MENINGOCOC ST MORAXELLA STREPTO STAFILO H inflenzae VIBRIO cholerae C PASTEURELLA FRANCISELLA t LISTERIA
PEPTOSTRPTOCOC
PROPIONEBACTER
MENINGOCOC
ST
MORAXELLA
STREPTO
STAFILO
H inflenzae
VIBRIO cholerae
C
PASTEURELLA
FRANCISELLA t
LISTERIA
B
LEGIINELLA pn
BRUCELLA spp
ENTEROB- cee
ENTEROBACTER

+

LEPTOSPIRA

BORRELIA

MYCOPLASMA

CHLAMYDIA

RICKETTSIA

BRUCELLA

PROTEUS

PSEUDOMONAS

SERRATIA

YERSINIA spp

MICOBACTERII

Mecanism actiune :

  • - fix subunit ribozomala 30 S → ihiba sisnteza proteica

Mecanism rezistenta

  • - ↓ acces tinta : ↓ transport activ / eflux activ

  • - Modificari ribozomale

  • - Inactivare chimica

FENICOLI

Infectii severe cu germeni sensibili dk

nu sunt accesbile alte AB :

- -
-
-
Infectii severe cu germeni sensibili dk nu sunt accesbile alte AB : - - meningite purulente

meningite purulente

abces cerebral

supuratie pulmonara

Infectii severe cu germeni sensibili dk nu sunt accesbile alte AB : - - meningite purulente

Ricketssioze - alternativa

PEPTOSTREPTOCOC O STREPTO spp NEISSERIA spp BACTEROIDES ENTEROCOC FUSOBACTERIUM STAFILOCOC HAEMOPHILUS infl. ACTYNOMICES SALMONELLA CLOSTRDIUM BACILLUS
PEPTOSTREPTOCOC
O
STREPTO spp
NEISSERIA spp
BACTEROIDES
ENTEROCOC
FUSOBACTERIUM
STAFILOCOC
HAEMOPHILUS infl.
ACTYNOMICES
SALMONELLA
CLOSTRDIUM
BACILLUS spp
SHIGELLA
LISTERIA
YERSINIA
FRANCISELLA t
BURKOL. Cepacia
S. maltophilia
BRUCELLA
VIBRIOS spp

+

CHLAMYDIA spp

MYCOPLASMA spp

RICKETSSIA spp

-

MYCOBACTERII

PROTEUS

KLEBSIELLA

PSEUDOMONAS

SERRATIA

PROVIDENCIA

SULFAMIDE

1. Boala Crohn : salazopirina 2. Nocardioza 3. Toxoplasmaoza 4. Dermatita herpetiforma ANAEROBI CGP CGN Majorit
  • 1. Boala Crohn : salazopirina

  • 2. Nocardioza

  • 3. Toxoplasmaoza

  • 4. Dermatita herpetiforma

ANAEROBI CGP CGN Majorit BGN BGP H.influenzae ENTERO-cee NOCARDIA Shigella E.coli
ANAEROBI
CGP
CGN
Majorit BGN
BGP
H.influenzae
ENTERO-cee
NOCARDIA
Shigella
E.coli

+

MYCOBATERIUM LEPRAE TOXOPLASMA

-

GERMENI INTERMEDIARI

SULFAMIDE ASOCIATE

ITU
ITU
3. -
3.
-

1. ACUTIZARI BRONSITE CR

SULFAMIDE ASOCIATE ITU 3. - 1. ACUTIZARI BRONSITE CR 2. BOLI DIAREICE 5. SANCRU MOALE cistita

2. BOLI DIAREICE

5. SANCRU MOALE

  • cistita acuta necomplic

    • - profilax cistite recidiv

      • 4. PROSTATITA ACUTA

ANAEROBI STAF AUREUS NEISSERIA spp STAF epidermid ENTEROCOC PROTEUS LISTERIA SALMONELLA SHIGELLA NOCARDIA H. influenzae E.
ANAEROBI
STAF AUREUS
NEISSERIA spp
STAF epidermid
ENTEROCOC
PROTEUS
LISTERIA
SALMONELLA
SHIGELLA
NOCARDIA
H.
influenzae
E.
coli
KLEBSIELLA
ENTEROBACTER
PROVIDENCIA
VIBRIO

+

  • 6. TOXOPLASMOZA ( CTX )

  • 7. PNEUMOCISTOZA ( CTX )

8.NOCARDIOZA

9.MALARIE ( fansidar )

CAMPYLOBACT

BRUCELLA

LEGIONELLA

+ PNEUMOCISTIS CARINII TOXOPLASMA GONDI - MYCOPLASMA spp CHLAMYDIA spp SPIROCHETE
+
PNEUMOCISTIS CARINII
TOXOPLASMA GONDI
-
MYCOPLASMA spp
CHLAMYDIA spp
SPIROCHETE

RIFAMICINE

RIFAMPICINA

RIFAMICINE RIFAMPICINA 1 . MENINGITE TBC / non-TB CGP CGN BACTEROIDES BGP HAEMOPHIL infl ( +

1. MENINGITE TBC / non-TB

CGP CGN BACTEROIDES BGP HAEMOPHIL infl ( + clostridii diffcile) LEGIONELLA spp Majorit BGN
CGP
CGN
BACTEROIDES
BGP
HAEMOPHIL infl
( + clostridii
diffcile)
LEGIONELLA spp
Majorit BGN

+

MYCOPLASMA spp

CHLAMYDIA spp

BRUCELLA spp

MYCOBACTERIUM spp

2. TBC pulmonar / extra

( + alte anti-TB )

3. INF OSTEOARTIC STAFILOCOCICE

4. ENDOCARDITA

STAFILOCOCICA

( + VANCO )

5. SEPSIS

  • 6. LEPRA

  • 7. BRUCELOZA

  • 8. STERILIZ PORTAJ NAZO-FARINGIAN

- menigococ, H. influenzae, stafilococ, streptococ

  • 9. LEGIONELOZA

10. PROFILAX SECUND INF MATERIALE PROTETICE

11. LEISHMANIOZA CUTANATA

12.INF ANAEROBI

13 PROFILAXIE infectii cu MAC la imunD (RIFABUTIN )

RIFABUTIN

RIFABUTIN RIFAMICINE MYCOBACTERIUM - tuberculosis - avium-intracellular (MAC ) - alte mycobacterii atipice INDICATII - inf

RIFAMICINE

MYCOBACTERIUM

  • - tuberculosis

  • - avium-intracellular (MAC )

  • - alte mycobacterii atipice

INDICATII

  • - inf cu MAC ( + CLARITO / AZITRO )

  • - inf cu Mycobacter TB la pac care primesc TARV cu INNRT / IP

  • - profilaxie MAC

BENZIMIDAZOLI

-metronidazolul-

BENZIMIDAZOLI -metronidazolul- 1. INF cu ANAEROBI 2. COITA PSEUDOMEMBRANOASA 3. TETANOS 4. INF H. pylori- trat
  • 1. INF cu ANAEROBI

  • 2. COITA PSEUDOMEMBRANOASA

  • 3. TETANOS

  • 4. INF H. pylori- trat ulcer gastric

  • 5. AMIBIAZA INTESTINALA si HEPATICA

  • 6. GIARDIOZA

  • 7. TRIHOMONIAZA

  • 8. ACNEE ROZACEE

  • 9. VAGINOZA

    • 10. PROFIL inf anaerobi in interv pe tub diges /prostata

BENZIMIDAZOLI -metronidazolul- 1. INF cu ANAEROBI 2. COITA PSEUDOMEMBRANOASA 3. TETANOS 4. INF H. pylori- trat

Bacterii strict AEROBE

PEPTOSTREPTO VEILONELLA BACTEROIDES PREVOTELLA FUSOBACTERIUM MOBIULUNCUS CLOSTRIDIUM CAMPYLBACTER EUBACTERIUM H. PYLORI BIFIDOBACTERIUM ACTINOMYCES PROPIONIBACTERIUM
PEPTOSTREPTO
VEILONELLA
BACTEROIDES
PREVOTELLA
FUSOBACTERIUM
MOBIULUNCUS
CLOSTRIDIUM
CAMPYLBACTER
EUBACTERIUM
H. PYLORI
BIFIDOBACTERIUM
ACTINOMYCES
PROPIONIBACTERIUM

OXAZOLIDINDIONE

1. PNEUMONII severe nosocomiale cu 2. INFECTII severe STAF MR m PARTI MOI pneumococi rezistenti Concentrare
1. PNEUMONII
severe nosocomiale cu
2. INFECTII severe
STAF MR m
PARTI MOI
pneumococi rezistenti
Concentrare
superioara in
plaman fata de
vanco !!!
3. INFECTII SISTEMICE cu:
-
enterococi Vanco-R ,
-
STAF metiR
-
Vanco -R
4. INF cu Mycobacterii (dk prima inie nu poate fi utilizata
PEPTOSTRPTOCOC STREPTO STAF ms / mr visa / gisa BACTEROIDES fragilis FUSOBACTERIUM spp ENTEROCOC faecalis, faecium
PEPTOSTRPTOCOC
STREPTO
STAF ms / mr
visa / gisa
BACTEROIDES fragilis
FUSOBACTERIUM spp
ENTEROCOC
faecalis, faecium
PNEUMOCOC
ps / pr
BACILLUS spp
MORAXELLA
CLOSTRIDIUM spp
CROYNEBAC
BORDETELLA
LISTERIA m
HAEMOPHIL. Infl
ERYSIPELOTHRIX
RHODOCOCUS equi
ENTEROBACT-cee
PSEUDOMONAS
spp

POLIPEPTIDE CICLICE

  • 1. INF URINARE cu BGN multi-R (inclusiv Piocianic)

  • 2. Topic :

    • - aerosoli: MUCOVISCIDOZA

    • - oral : DECONTAMINARE DIGESTIVA

    • - inra-articular

    • - intra-tecal

    • - intra-conjunctival

    • - auricular : OTITE EXTERNE

    • - inf CUTANATE

ENTEROBAC-cee Exceptie : SERRATIA PROTEUS PROVIDENCIA PIOCIANIC HEAMOPH. Infl PASTEURELLA m
ENTEROBAC-cee
Exceptie :
SERRATIA
PROTEUS
PROVIDENCIA
PIOCIANIC
HEAMOPH. Infl
PASTEURELLA m

MEDICAMENT

DOZE

ADM

ADULT

COPIL

POLIMIXINA E

150-200 MU /kg/zi :

p.o.

6 – 8 ore

= COLIMICINA=

50 -100 MU/kg/zi : i.m / i.v.

8 – 12 ore

POLIMIXINE B – se administreaza numai local : colir, unguent, pomada

NITROFURANI

- cu utilizare digestiva -

Inf digestive non-invazive: - bacteriene - parazitare
Inf digestive non-invazive:
-
bacteriene
-
parazitare
CGP ENTEROBAC-cee -SALMONELLA -SHIGELLA -E. coli EP + AMOEBE TRICHOMONAS
CGP
ENTEROBAC-cee
-SALMONELLA
-SHIGELLA
-E. coli EP
+ AMOEBE
TRICHOMONAS
Inf URINARE: - Joase - Necomplicate - Femeia grav
Inf URINARE:
-
Joase
-
Necomplicate
-
Femeia grav

NITROFURANI - cu utilizare urinara -

STAFILOCOCI ENTEROCOCI PROTEUS indol - SALMONELLA E. COLI
STAFILOCOCI
ENTEROCOCI
PROTEUS indol -
SALMONELLA
E. COLI

ACIDUL FUSIDIC

1. INF STAFILOCOCICE - localizate - generalizate 2. COLITA PSEUDOMEMBR 3. PROFILAXIA INF : - osoase
1.
INF
STAFILOCOCICE
-
localizate
-
generalizate
2. COLITA
PSEUDOMEMBR
3. PROFILAXIA INF :
-
osoase
  • - parti moi

    • 4. INF CU ANAEROBI GRAM +

PEPTOSTRPTOCOC STAF - MS/ MR STREPTOCOC pyogenes CGN CLOSTRIDIUM CORYNEBACT ACTYNOMICES LISTERIA NOCARDIA CLOSTRIDIUM
PEPTOSTRPTOCOC
STAF - MS/ MR
STREPTOCOC
pyogenes
CGN
CLOSTRIDIUM
CORYNEBACT
ACTYNOMICES
LISTERIA
NOCARDIA
CLOSTRIDIUM

FOSFOMICINA

1. INF MENINGIENE cu: - BGN rezistenti ANAEROBI + CFS III/ carbapeneme/ CIPRO - STAF +
1.
INF MENINGIENE cu:
-
BGN rezistenti
ANAEROBI
+ CFS III/ carbapeneme/ CIPRO
- STAF + CFS III
2. INF OSTEOARTICUL cu
BGN rezistenti
+ CFS III/ carbapeneme/
CIPRO
STAF - MS / MR
PNEUMOCOC
ENTEROCOC
faecalis / faecium
NEISSERIA spp
3. ITU joase,
STREPTOCOC
necomplicate-
Gr A, B, D
monodoza
ENTEROBAC- cee
SERRATIA
PSEUDOMONAS
PROVIDENCIA
PROTEUS m.
4. INF SISTEMICE cu STAF MS + Pen M
ACINETOBACTE

LINCOSAMIDE

Absorbtie digestiva : T ½ : Leg proteine plasm : Difuziune tisulara Eliminare Efecte adverse 26

Absorbtie digestiva :

T ½ :

Leg proteine plasm :

Difuziune tisulara

Eliminare

Efecte adverse

Absorbtie digestiva : T ½ : Leg proteine plasm : Difuziune tisulara Eliminare Efecte adverse 26