Beruflich Dokumente
Kultur Dokumente
August 2012
August 2012
Liver with Reidel lobe, a prominent caudal extension of the right lobe.
Wanless I.R. 2012
August 2012
Schematic representation of segments of liver according to vascular anatomy (nomenclature of Couinaud revised Strasberg)
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Ultrastructure of hepatocyte
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Normal portal tract from a human liver, showing several small ducts, two arteries, a portal vein, and occasional lymphocytes. (H&E)
Wanless I.R. 2012
August 2012
Acinar structure of the hepatic microcirculation, as conceived by Rappaport and modified by Matsumoto and Kawakami.
Reproduced from with permission from Elsevier.) Wanless I.R. 2012
It consists of the parenchyma centered around the terminal branches of the hepatic artery and portal vein. It is to be noted that the cells in Zone 1 nearest these nutrients, while the cells of Zone 2 are less favored and those of Zone 3 near the terminal hepatic venules are least favorably situated. Redrawn after Rappaport AM, et al. Anat. Rec., 119:11, 1954
August 2012
Blood supply of one simple liver acinus and the zonal arrangement of cells.
Wanless I.R. 2012
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Muscle
Glucose
Glucose
Urea
Pyruvate
Alanine Alanine
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Step 1 Modification
Hydroxylation Sulfoxidation Dealkylation Reduction Oxidative Dehalogenation Deamination
Step 2 Conjugation
With Uronic acids Sugars Sulfate Glutathione Taurine Glycine
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Molar Ratios
15
3 1
Cholesterol 4%
Phospholipids 24%
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Saturated zone
0 100
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Chenodeoxycholic
+ Glycine
Cholic Acid
+ Taurine
Taurochenodeoxycholic Taurocholic
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Catabolism
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Intracellular storage
Ferritin - thousands of iron atoms
Tf
GI T R A C T
Erythroid Marrow
Hepatocytes
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Multiple Hydroxylations
HO
OH
OH
COOH
HO
OH
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CH2
CH2 H C () CH3 CH
CH3
CH
N ( ) C-H N
CH3
CH3
Haem oxygenase
COOH CH2 CH2 CH3 H N C N H O
CH3
CH3
CH3
CH2 CH
Biliverdin IX ()
Biliverdin reductose
COOH CH2 CH2 H N H C H N H COOH CH2 CH2 CH3 H C N H O
CH3
CH2 CH H C
CH3
CH3
CH2 CH
Bilirubin IX ()
N H
OH CH2 CH
Bilirubin IX () diglucuronide
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A. Bilirubin IX ()
B. Bilirubin IX () diglucuronide
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Gallbladder Filling
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Gallbladder Emptying
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