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Types of Hemophilia
The mutations that cause low levels of clotting factor are carried recessively
on the X chromosome.
As women have two X chromosomes (XX), the mutated gene would have to
be present on both chromosomes to cause the disease, and this is
exceedingly rare.
Since men have only one X chromosome (XY), one copy of the mutated
hemophilia gene is enough to cause the disease, so males who inherit the
gene will be affected.
Hemophilia Causes Bruising and Mild to Severe Bleeding
Severe Hemophilia: Spontaneous joint bleeding can cause severe pain and
physical deformity as cartilage and surrounding bones are damaged. Further,
gastrointestinal, urinary tract, or intracranial bleeding can occur and require
immediate medical attention. Even mild physical trauma to the head may
result in intracranial bleeding, a very serious condition.
Hemophilia symptoms are often not apparent at birth unless the disorder is
severe.
Moderate hemophilia symptoms may not be noticed until a child starts to
crawl, when unusual bleeding and bruising become more apparent.
A mild case of hemophilia may go unnoticed until dental work, surgery, or a
serious injury results in unusual bleeding.