Case Study II

Modular Bio Containment facility BSL 3 Seed Lab

Thomas Meyer
tmmy@nnepharmaplan.com +49 172 610 11 81

The Case

BSL 3 Seed Lab Client is Confidential Location: Europe Reasons to choose modular approach:

Fast track realisation, start up before the next vaccination campaign

starts in autumn Removable building: in case of an outbreak, the building could be moved to e.g. Spain

Overview
BSL 3 Seed Laboratory within 6 months

Rigging August 17.-18.2007

Planning

(artist view made by our visualisation department)

Realisation

Layout, Cleanroom classes

Layout, pressure levels

Shell in shell system

Construction

Requirements
Several regulations have to be considered in the design: e.g. DIN/EN Norms, GenTSV, EN 1717, DIN 1946 part 7, ..

First objective: protection of the staff and environment Method: Disinfections, HAVC, procedures, Controlled access Method: Locked doors and windows, interlocking, card reader, code switches Person protection by visible workplaces Method: doors with windows, walls with windows Smooth surfaces, easy to clean Method: pool design, pvc welded on floors and wall, trespa ceiling Personnel safety equipment Safety procedures Method: SOPs, touch less taps, emergency shower, eye shower, towel and disinfection dispenser

Requirements

Waste treatment Method: double door decontamination autoclave, kill tank, H13 filters Disinfection of working table tops Method: curb on table tops, water retention on the floor, no floor drains Fire protection Method: F90 Building, F30 Windows, fire extinguisher, no sprinkler, floor curb at the entrance, problem to keep underpressure Drinking water protection Method: water line separation valve Hermetic closure of the building in case of an emergency fumigation Emergency power supply for ventilation, illumination, emergency call and communication systems Two escape routes

Decontamination Autoclave

rooms

PVC on walls and floor, Trespa on the ceiling

Media connections

Minimised, centralised, In separate insulated panels

rooms

Fumigation with H2O2, triple glas windows, Shell-System fumigation with formaldehyde

HVAC

Police filter H13

Fumigation with formalin

Volume control valves

All installed in the technical area

Waste air incineration

For kill tank

Shell-Filter H13

Fumigation with formalin

Pressure regulator

For small rooms with a water valve

Fumigation with H2O2

Disinfection procedure 10 pages word document! VHP compatibility: Steris-Bioquell

(see also: http://www.bioquell.com/)

Time schedule

Time Schedule

Cost benchmarks

Equipment; 1.184.725,0 0; 83% Engineering / Hours; 185.000,00; 13% Transport; 50.000,00; 4%

Monitoring; 30.925,00; Lab 3% Furniture; 4.800,00; 0%

Decontamin ation Autoclave; 82.500,00; 7% Waste Water Treatment; 96.500,00; 8% HVAC ; 350.000,00; 30%

Modules; 620.000,00; 52%

1,4 Million Euro 5,400 /m

Questions ?