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HIV - Wikipedia, the free encyclopedia

membranes close together, allowing fusion of the membranes and subsequent entry of the viral capsid.[37][38] After HIV has bound to the target cell, the HIV RNA and various enzymes, including reverse transcriptase, integrase, ribonuclease, and protease, are injected into the cell.[37] During the microtubule-based transport to the nucleus, the viral single-strand RNA genome is transcribed into double-strand DNA, which is then integrated into a host chromosome. HIV can infect dendritic cells (DCs) by this CD4-CCR5 route, but another route using mannose-specific Ctype lectin receptors such as DC-SIGN can also be used.[40] DCs are one of the first cells encountered by the virus during sexual transmission. They are currently thought to play an important role by transmitting HIV to Tcells when the virus is captured in the mucosa by DCs.[40] The presence of FEZ-1, which occurs naturally in neurons, is believed to prevent the infection of cells by HIV.[41] Replication and transcription Shortly after the viral capsid enters the cell, an enzyme called reverse transcriptase liberates the singlestranded (+)RNA genome from the attached viral proteins and copies it into a complementary DNA (cDNA) molecule.[42] The process of reverse transcription is extremely Mechanism of Viral Entry/Membrane Fusion error-prone, 1. Initial interaction between gp120 and CD4. 2. and the Conformational change in gp120 allows for resulting secondary interaction with CCR5. 3. The distal tips mutations may of gp41 are inserted in to the cellular membrane. 4. cause drug gp41 undergoes significant conformational change; resistance or folding in half and forming coiled-coils. This allow the virus process pulls the viral and cellular membranes to evade the together, fusing them. body's immune system. The reverse transcriptase also has ribonuclease activity that degrades the viral RNA during the synthesis of cDNA, as well as DNA-dependent DNA polymerase activity that creates a sense DNA from the antisense cDNA.[43] Together, the cDNA and its complement form a double-stranded viral DNA that is then transported into the cell nucleus. The integration of the viral DNA into the host cell's genome is carried out by another viral enzyme called integrase.[42] This integrated viral DNA may then lie dormant, in the latent stage of HIV infection.[42] To actively produce the virus, certain cellular transcription factors need to be present, the most important of which is NF- B (NF kappa B), which is upregulated when T-cells become activated.[44] This means that those cells most likely to be killed by HIV are those currently fighting infection.

The HIV replication cycle

en.wikipedia.org/wiki/Human_immunodeficiency_virus

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