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We are 100% user supported! Home >> Flashcards >> Medical >> Hepatitis

Details Title: Hepatitis Description: hepatitis Total Flash Cards: 49 Created: 10/09/2008 05:30:00
Cards in this set:
Term Definition

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What is Hepatitis?

A descriptive term that refers to infection with any of the 6 hepatotrophic viruses. A, B, C,D, E, & G.

Term

Definition

How is Hep A transmitted?

Fecal-Oral route Contaminated seafood/water etc..

Term

Definition

What is the incubation period of Hep A?

15-45d (3w average) Remember Hep A: abrupt onset Hep B: gradual onset Hep C: insidious onset.

Term

Definition

True or False A pt with Hep A is infectious for 2-3w in the late infection and early clinical course.
Term Definition

True.

True or False ALT/AST is elevated 1-2w presymptoms in Hep A.


Term Definition

True

Concerning labs for Hep A, explain the difference between:


Hep A IgG Hep A IgM


Definition

If positive, Hep A IgG shows past infection and lasts indefinately. If positive, Hep A IgM (moment) shows a current infection and can last up to 3-6m before it returns to normal.

Term

What is the adverse relationship that exists in the Hep A while normally the most begign of the 6 comorbid states of Hep A & Hep C. hepatitis, becomes an aggrevating factor to Hep C & worsens its outcome when they exist together.
Term Definition

What labs are ordered for the hepatitis pt?

CBC Lytes w/LFTs PT/PTT Viral markers HAV antibody (appears when s/s present 1-8w) Anti HAV IgM (Dx made by this lab) Anti HAV IgG

Term

Definition

How is Hep A diagnosed?

Anti HAV IgM it is present when s/s appear becomes negative when IgG pops up Pt will have life long immunity after.

Term

Definition

What is the tx for Hep A?

Prevention:

Vaccine (2 inj. 6-12m apart) avoid contaminated food Post exposure: Immune globulin

Term

Definition

Is it true that there is no chronic disease state of Hep A?


Term Definition

Yes.

True or False Hep B is the only one of the Hepatitis to be considered an STD.
Term Definition

True.

How is Hep B transmitted?

Sex (semen) Blood Saliva Mucous mem. Mom to fetus Tattoo parlors

Term

Definition

True or False Hep B has a asymptomatic carrier state.


Term Definition

True.

What is one of the worse clinical courses in Hep B?

Submassive Hepatic Necrosis 60% fatality rate

Term

Definition

What is the Hep B surface antigen?


Term Term

lab that is positive in the acute stage of infection. Usually positive in the 4th-12th week.
Definition Definition

True or False 80-90% of the time the Hep B surface antigen will disappear in about 3m.

True.

Term

Definition

True, the Hep B surface antigen usually falls away in about 3m 80-90% of cases. If the Hep B surface antigen is positive after 6m of acute infection, the pt is a carrier.
Term Definition

True or False

True or False The Hep B surface antibody:


True.

indicates past infection appears after ABsAG dissappears indicates full recovery provides immunity
Definition

Term

True or False The Hep B core antibody has two parts: 1. IgG 2. IgM
Term Definition

True

True or False If the Hep B surface antigen is positive the pt is in a highly infectious state.
Term Definition

True.

What is the tx for Hep B?

Pegelated Interferon Alpha Epivir

Term

Definition

What is the post exposure tx for Hep B?

Hep B panel first. then if needed.......... HBIG within 24-72h.

Term

Definition

Is the treatment for Hep B dependent on the viral load and ALT levels of the pt?

Yes.

Term

Definition

What is the most important lab in regard to treating hepatitis?


Term Definition

ALT

In the pt that has hepatitis, what could the It may indicate that the liver is damaged to the absence, decline, or low level of liver enzymespoint be that it no longer is able to produce enzymes. an indicator of?
Term Definition

What disease state must be present first in order Hep B. to diagnose Hep D? If you vaccinate against Hep B, then you really vaccinate against Hep D.
Term Definition

True or False We did not test our blood supply for Hep C prior to 1992
Term Definition

True

True or False HIV & Hep C aggrevate one anothers disease states.
Term Definition

True

True or False 90% of IVDA have Hep C if > 45y.


Term Definition

True.

What is the #1 reason for Liver Transplant?


Term Definition

Hep C
Transfusion before July 1992 Injecting or snorting drugs-even once Ear, body piercing Hemodialysis organ transplant Multiple sex partners Health care worker

What are some risk factors for Hep C infection?


Term

Definition

How does the onset of Hep C differ than that of A or B?


Term Definition

Much slower, insidious onset.

What are some s/s of Hep C?

may have none, many asymptomatic lethargy fever nausea ab pain jaundice SKIN RASH AND HEADACHES In HIV population ALT can fluctuate

Term

Definition

What do most pts with HIV die of today? Bleeding complications related to Hep C. If they do not have Hep C, they may live a long life.
Term Definition

True or False Liver biopsy is the gold standard for amount of liver damage in hepatitis C, but has risk of bleeding & small risk of death.
Term Definition

True

True or False Serial levels of HCV-RNA are crucial in management of Hep C.


Term Definition

True

What is true about HCV-RNA?

Sucessfully treated pts loose HCV-RNA during tx. If HCV-RNA is zero after 6m after tx, cure is durable Cured pts have been followed up to 13y with no return of HCV-RNA

Term

Definition

What population should not be treated for Hep C?

Depressed----suicide Severe heart disease Autoimmune diseases

Term

Definition

True or false

True.

Regarding the tx of Hep C: Interferon is a protein the body makes to fight viral infections. It protects healthy cells & increases immune response.
Term Definition

True or False Treatment of Hep C is sucessful when no Hep C antibody and no vial load exist.
Term Definition

True.

True or False In treating Hep C, if HCV-RNA blood levels fall with the first dose of interferon and is zero by one month of tx the pt is curable.
Term Definition

True

What annual labs should be ordered for chronic Hep C pt?


CT liver (or u/s) LFTs PT/PTT Hep C viral load Alpha Feto Protien

Term

Definition

When a pt with HepC is tx with interferon what are the S/E?


Flulike symptoms NO TYLENOL/NSAIDS/ETOH medicate for discomfort with oxycodone beware of suicide attempts causes fatigue and sleep disturbance.

Term

Definition

Regarding Hep C, Is it true that Ribavirin is an antiviral drug which cannot eleliminate HCV by itself but when combined with interferon it doubles its efficacy?
Term Definition

Yes

Evalute the following Hep B panel results & explain its meaning to the pt.:

1. No acute disease 2. Immunity exists due to vaccination 3. No evidence of past exposure/infection.

Hep B Surface Antigen: Negative

Hep B Surface Antibody: Positive Hep B Core Antibody: Negative


Definition

Term

What are some S/E of Ribravirin?

ANEMIA TO THE POINT OF DEATH cough SOB Rash dry skin

Term

Definition

True or False In treating Hep C, using the cobonation of Ribavirin and Interferon results in twice the effeciveness.

True, but ribavirin cannot be used alone.

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