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A myeloblast is a large cell, 12-20 microns in diameter, with a nucleus that takes up most of the cell. Nuclear chromatin is fine, with little condensation and fairly homogenous in appearance. Nucleoli may vary in number and are apt to be large. The scanty cytoplasm is blue without granules.
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A promyelocyte may be the same size as the myeloblast or even larger. Unlike the myeloblast, the promyelocyte's cytoplasm contains large black or purple granules. Nucleoli may be present.
The myelocyte is smaller than the myeloblast or the promyelocyte. Unlike the myeloblast and promyelocyte, the myelocyte's cytoplasm contains specific granules, i.e. brick-red (eosinophils), large, blue-black granules (basophils), and lilac granules (neutrophils). The nucleus still has a round or oval shape and no nucleoli are present. Myelocytes are not seen on a normal peripheral blood smear.
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Metamyelocytes (Juvenile) are smaller than the myelocytes. There is more marked clumping of the nuclear chromatin so that the nucleus becomes much denser, takes up less than half the cell volume, and is indented (kidney-shaped).
The band (stab) is similar to the metamyelocyte but the band is smaller and has a horseshoe-shaped nucleus. The cytoplasm may contain fine lilac granules (neutrophilic), brick-red granules (eosinophilic) or large blue-black granules (basophilic). Bands normally account for 0-5% of the total leukocyte count in circulating blood of the adult.
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Metamyelocytes (Juvenile) are smaller than the myelocytes. There is more marked clumping of the nuclear chromatin so that the nucleus becomes much denser, takes up less than half the cell volume, and is indented (kidney-shaped).
The band (stab) is similar to the metamyelocyte but the band is smaller and has a horseshoe-shaped nucleus. The cytoplasm may contain fine lilac granules (neutrophilic), brick-red granules (eosinophilic) or large blue-black granules (basophilic). Bands normally account for 0-5% of the total leukocyte count in circulating blood of the adult.
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A segmented neutrophil (poly) is approximately 12-14 microns in diameter. This is the final stage of granulocytic development. Normal polys generally have two to five lobes. Hypersegmented polys, containing six or more lobes, are characteristically seen in megaloblastic anemias. Polys normally account for 45-75% of a normal differential in an adult. What is this cell?
A monocyte has blue-gray cytoplasm and a lobulated nucleus. It's distinguished from other leukocytes by the folding-over of the nuclear lobe (fetal-shaped). 4-11% in a normal blood differential.
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Basophils are present in small numbers (0-3%) in a normal blood smear. Dark coarse granules and indistinct nucleus are characteristic. The basophil is a source of histamine and involved with allergic and inflammatory/immune responses. Increased numbers are seen in myeloproliferative disorders, e.g. chronic myelogenous leukemia and polycythemia vera. What is this cell?
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