AUTHOR/S, DATE PUBLISHED; JOURNAL NAME de Frana ND, Poli MC, Ramos PG, Borsoi CS, Colella R (2011).

Rev Bras Hematol Hemoter

TITLE OF THE STUDY

MAJOR OBJECTIVES

DELINEATED FACTORS Age, gender, blood group O

LOCUS

METHOD

Titers of ABO antibodies in group O blood donors.

Mair B, Benson K. (1998). Transfusion.

Evaluation of changes in hemoglobin levels associated with ABOincompatible plasma in apheresis platelets.

Group O donations stratified by gender and age were randomly titrated to identify the best source of products for apheresis and exsanguinous transfusion. To identify possible hemolysis related to the transfusion of plasma-incompatible apheresis platelets.

Banco de Sangue de So Paulo, So Paulo, SP, Brazil.

Antibody titration (conventional tube technique) Statistics: the Fisher exact and KruskalWallis tests.

Transfusion of plasma-incompatible apheresis platelets (minor ABO incompatibility), hemoglobin levels Unexposed to platelets and undergoing treatment for acute leukemia and thalassemia or BMT, transfused leucodepleted platelets, Platelet transfusion refractoriness

Rao, P.; Joshi, S. (2007). Asian Journal of Transfusion Science

Determination of ABO titre for pheresis platelet transfusion

To determine ABO titre for pheresis platelet transfusion

Department of Pathology and Laboratory Medicine, University of South Florida College of Medicine, Tampa, USA. B-9, Kanara Business Centre, Off Link Road, Ghatkopar (E), Mumbai - 400075, INDIA

Determination of Pretransfusion and posttransfusion hemoglobin levels

Platelet transfusion refractoriness

Dong II Won; Byung Chang Kim (2012). Laboratory Medicine

Optimized Flow Cytometry to Measure Anti-ABO Immunoglobulin G

Accurate measurement of ABO antibody levels before and after ABOincompatible organ transplantations.

Mean fluorescence intensity (MFI) ratio, Anti-ABO IgG, Residual hemagglutination and hemolysis,

American Society for Clinical Pathology 33 W Monroe, #1600 Chicago, IL 6060

Optimized Flow Cytometry [Flow ABO Ab and the column agglutination technique (CAT)]

Karafin MS, Blagg L, Tobian AA, King KE, Ness PM, Savage WJ.(2012). Transfusion

ABO antibody titers are not predictive of hemolytic reactions due to plasmaincompatible platelet transfusions.

To evaluate all apheresis PLT (AP) transfusions for 3 months.; to determined the antiA and/or the anti-B immunoglobulin (Ig)G titer for all incompatible APs.

Apheresis PLT (AP) transfusion [anti-A and/or the anti-B immunoglobulin (Ig)G titer for all incompatible APs]; Posttransfusion direct antiglobulin test (DAT) and eluate

Department of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.

Gel titer method

Submitted by: Valdez, Dennis Bryan A.

AUTHOR/S, DATE PUBLISHED; JOURNAL NAME M. Libich (1961). Immunology.

TITLE OF THE STUDY

MAJOR OBJECTIVES

DELINEATED FACTORS Antigenic components in crude diphtheria toxin and tetanus toxoid

LOCUS

METHOD

Bobrovnik SA. (2012). Ukr Biokhim Zh.

Immunochemical Titration of Antigens and Antibodies in Electric Field: Titration of Antigens in Complex Systems and Titration of Individual Determinant Antigen Groups Analysis of titration curves of serum antibodies obtained by ELISA Probiotic-associated high-titer anti-B in a group A platelet donor as a cause of severe hemolytic transfusion reactions.

To develop a quantitative immunochemical method suitable for titration of antigens and antibodies in complex systems. New interpretation of dose-dependent titration curves

Vintage House, 37 Albert Embankment, London SE1 7TL

A quantitative immunochemical method

Daniel-Johnson J, Leitman S, Klein H, Alter H, Lee-Stroka A, Scheinberg P, Pantin J, Quillen K. (2009). Transfusion. Shirey,R.S., Cai, W., Montgomery R.A., Chhibber, V., Ness, P.M., & King, K.E. (2009). Transfusion.

To determine Hemolytic transfusion reactions (HTRs) along with transfusion of platelets (PLTs) containing ABOincompatible plasma. IMMUNOHEMATOLOGY: To monitor ABO Streamlining ABO antibody titers in 53 antibody titrations for ABO-incompatible monitoring ABOkidney transplants incompatible kidney (INKTs) transplants

serum antibodies, monoclonal antibodies and polyreactive immunoglobulins Plateletpheresis component, Transfusion of platelets (PLTs), ABO-incompatible plasma

Russia

ELISA

Department of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.

Plateletpheresis component determination

Anti-A and/or anti-B anti-human globulin (AHG) titers

Department of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.

Revised test tube (TT) method without RT; anti-immunoglobulin G (IgG) gel microcolumn (IgG gel)

Ata P, Cetinkaya F, Ozgezer T, Ozel L, Tulunay A, Eksioglu E, Titiz MI. (2012). Transplant Proc.

Flow cytometric detection of anti-AB antibody titers in blood group O recipients of blood group A2 donor kidneys.

To analyze 20 living related renal transplant couples to detect recipient antiA2 antibody

Flow cytometric antibody titers Blood groups subtype, Anti-A2 antibody titers,

Department of Molecular Genetics, Haydarpasa Numune Research and Training Hospital, Genetic Diseases Diagnosis Center, Turkey.

Flow cytometric analysis; lectin-based dilution assay; hemagglutination method

Submitted by: Paltep, Rashell Anne C.

AUTHOR/S, DATE PUBLISHED; JOURNAL NAME A. RICHARDSON JONES and LORRAINE KANEB. (1960). Blood

TITLE OF THE STUDY

MAJOR OBJECTIVES

DELINEATED FACTORS cross reacting property of group 0

LOCUS

METHOD

Some Properties Of Cross Reacting Antibody Of The ABO Blood Group System

-to determine the spatial relationship between the site of action of the cross reacting antibody in group 0 serum and the antigens A or B of the cell. -establish the relationship between the titer of cross reacting antibody in the serum of group 0 pregnant women and the subsequent development of erythroblastosis in their newborn infants.

American Society of Hematology, 2021 L St, NW, Suite 900, Washington DC

mixed agglutination technic for directly demonstrating the adherence of two cells of differing specificity by cross reacting antibody

Paul R. Warner, PhD, and Theresa A. Nester.(2006) Am J Clin Pathol (ASCP)

ABO-Incompatible SolidOrgan Transplantation

To increase transplantation access, particularly in living-donor renal transplantation, efforts have been made to overcome the barrier of ABO incompatibility

N. D. deFrana, M.C. Poli, P.G. de Almeida Ramos, C.D.R. S.Borsoi, R. Colella (2011). Revista brasileira de hematologia e hemoterapia A. A. R. Tobian, R. S. Shirey, R. A. Montgomery, W. Cai, M. Haas, P. M. Ness and K. E. King. 2010 American Journal of Transplantation

Titers of ABO antibodies in group O blood donors.

to identify the best source of products for apheresis and exsanguinous transfusion.

- expression of antigen on the graft, positive organs; - low titer of antidonor ABO antibodies in the recipient before transplantation - ability to maintain low titers of antidonor ABO antibodies in the recipient after transplantation group O donations stratified by gender and age were randomly titrated

American Society for Clinical Pathology

- renal transplantation - Peritransplantation

Banco de Sangue de So Paulo, So Paulo, SP, Brazil.

ABO antibody titrations

ABO Antibody Titer and Risk of Antibody-Mediated Rejection in ABOIncompatible Renal Transplantation

To evaluate 46 individuals who received TPE to permit ABO-I kidney transplantatio.

-characteristics of individuals with and without antibodymediated rejection (AMR), and elevated titers -posttransplant ABO antibody titer and the correlation to antibody-mediated rejection

Johns Hopkins Medical Institutions, Baltimore, MD Cedars-Sinai Medical Center, Los Angeles, CA

- Human leukocyte antigen (HLA) crossmatch techniques - ow cytometry with T and B cells -histopathologic analysis of biopsies and diagnosis of rejection