Brighton, MA 02135 (216) 258-9777 luoxiaoyang2006@gmail.

com

XIAOYANG LUO

PROFESSIONAL SUMMARY
Highly trained scientist with in-depth expertise in neurodegenerative diseases, genetics, molecular and cell biology, and protein biochemistry. Proven record of research productivity. Outstanding scientific writing and oral presentation skills. Award-winning teaching and mentoring experience.

CORE COMPETENCIES
Scientific knowledge Critical thinking Innovation Planning & organizing Reliability Adaptation Laboratory techniques Problem solving Scientific writing & publication Peer review Public speaking Collaboration & Facilitation Communication Project management Teaching & mentoring

PROFESSIONAL EXPERIENCE
Research Fellow, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 2009 2013 Generated five mouse models for human neurological diseases research. Discovered novel neuregulin-1 proteolytic cleavage and its functional importance in neureguin-1 signaling. Elucidated a reversible function of neuregulin-1 N-terminal-fragment in schizophrenia pathogenesis. Unveiled isoform-specific functions of neuregulin-1 in myelin development in the central nervous system. Led writing of research proposals that won two major NIH grants for the laboratory in three years. Invited presentation at a leading international scientific meeting. Frequently invited for peer-review of manuscripts for high-impact scientific journals. Routinely supervised graduate students, medical students, and technicians. Skills/Expertise: Transgenic/knockin/knockout mouse generation/husbandry/genotyping/phenotyping/ tissue isolation, rodent behavioral analyses, mammalian cell line/neural stem cell/primary neuronal culture, DNA cloning/sequencing/transfection, site-directed mutagenesis, RNAi, lentiviral-mediated gene transfer, quantitative RT-PCR, Southern/northern/western blotting, ELISA, protein expression/extraction/purification, immunoprecipitation, in vitro myelination, in-situ hybridization, immunohistochemistry, immunocytochemistry, various microscopy techniques (confocal/electron microscopy, etc.) Postdoctoral Associate, The Jackson Laboratory, Bar Harbor, ME 2007 2008 Spearheaded research on normal and cancer stem cells. Skills/Expertise: Mouse colony management, neural stem cell culture, flow cytometry, Guava Viacount assay, cytotoxicity assays, apoptosis assays, and immunofluorescence microscopy. Graduate Student/Teaching Assistant, Boston College, Chestnut Hill, MA 2000 2007 Developed innovative membrane models for high-resolution X-ray diffraction analysis of myelin structure. Demonstrated myelin P0 structural dynamics during myelin development. Established and coordinated research collaborations. Trained and supervised undergraduate research assistants. Achieved university recognition on excellent undergraduate teaching performance. Skills/Expertise: DNA cloning, protein expression (in various cell culture or in vitro expression systems) and purification (FPLC and column chromatography), protein crystallography, SDS-PAGE, Native-PAGE, myelin purification, circular dichroism, spectrofluorometry, X-ray diffraction, HPLC, and mass spectrometry.

Project Manager, Five-zero Industries Inc., Changchun, China Led research and development of novel eco-friendly biodegradable materials. Targeted and maintained long-term raw-material suppliers. Recruited, trained and supervised technical personnel.

1995 2000

HONORS AND AWARDS

Invited seminar, Neuroscience Conference Regular member, The Society for Neuroscience Professional member, American Association for the Advancement of Science. Concept Award alternate, Department of Defense MS Research Program Elected full membership, Sigma Xi, The Scientific Research Society The Jackson Laboratory Postdoctoral Fellowship Donald J. White Teaching Excellence Award, Boston College 2011 2011 2011 2010 2008 2007 2008 2007

EDUCATION
Ph.D., Biology, Boston College, Chestnut Hill, MA Dissertation Title: Structural analysis of human and zebrafish P0 cytoplasmic domains and molecular characterization of P0 from Xenopus laevis. B.S., Biology, Fudan University, Shanghai, China 2000 2007 1990 1995

PUBLICATIONS
Luo, X., He, W., Hu, X., and Yan R. 2013. Overexpression of the neuregulain N-terminal fragment reduced astrogenesis by regulation of the Notch pathway. (In preparation) Luo, X., He, W., Hu, X., and Yan R. 2013. Reversible overexpression of BACE1-cleaved neuregulin-1 N-terminal fragment induces schizophrenia-like phenotypes in mice. Biol Psychiatry. (In press) Hu, X., He, W., Luo, X; Tsubota, K.E., and Yan, R. 2013. BACE1 regulates hippocampal astrogenesis via the Jagged-1-Notch pathway. Cell Rep. 4(1):40-49. Luo, X., Prior, M., He, W., Hu, X., Tang, X., Shen, W., Yadav, S., Kiryu-Seo, S., Miller, R., Trapp, B.D., and Yan, R. 2011. Cleavage of neuregulin-1 by BACE1 or ADAM10 protein produces differential effects on myelination. J. Biol Chem. 286(27):23967-23974. Luo, X., and Yan, R. 2010. Inhibition of BACE1 for therapeutic use in Alzheimer's disease. Int J. Clin Exp Pathol. 3(6), 618-628. Luo, X., Cerullo, J., Dawli, T., Hadaddin, Z., Inouye, H., Avila, R., Lees, J., Sharma, D., Xie, B., Costello, C.E., and Kirschner, D.A. 2008. Peripheral myelin of Xenopus laevis: Role of electrostatic and hydrophobic interactions in membrane compaction. J. Struct Biol. 162(1), 170-183. Xie, B., Luo, X., Zhao, C., Priest, C.M., Chan, S.Y., OConnor, P.B., Kirschner, D.A., and Costello, C.E. 2007. Molecular Characterization of myelin protein zero in Xenopus laevis peripheral nerve: equilibrium between non-covalently associated dimer and monomer. Int. J. Mass Spectrom. Ion Processes 268(2-3), 304-315. Luo, X., Inouye, H., Gross A.A.R., Hidalgo, M.M., Sharma, D., Lee, D., Avila, R.L., Salmona, M., and Kirschner, D.A. 2007. Cytoplasmic Domain of Zebrafish Myelin Protein Zero: Adhesive Role Depends on Conformation. Biophys J. 93(10), 3515-3528. Luo X., Sharma, D., Inouye, H., Lee, D., Avila, R.L, Salmona, M., and Kirschner, D.A. 2007. Cytoplasmic domain of human myelin P0 likely folded as a -structure in compact myelin. Biophys J. 92(5), 1585-1597. Xie, B., Luo, X., Kirschner, D.A., and Costello, C.E. 2006. Molecular Basis for Glycoprotein P0 Dimer in Native Membranes of Xenopus laevis Peripheral NerveNon-covalent equilibrium Between Dimer and Monomer. (Poster presentation for 54th ASMS - Glycoproteomics). Xie, B., Luo, X., Kirschner, D.A., and Costello, C.E. 2005. Mass Spectrometry Structural Investigation to Address Stability of Glycoprotein P0 Dimer. (Poster presentation for 2005 Meeting of the Society for Glycobiology).