STAT / ME 424, Fall 2013

Instructor Nicholas Keuler 1237 Medical Science Center nskeuler@wisc.edu Oce Hours: Tuesdays 9:45-10:45a, or by appointment Teaching Assistant Name: Han Chen Oce: 1335 Medical Science Center Email: hanchen@stat.wisc.edu Oce Hours: Mondays 2:15-3:15p, Wednesdays 1:30-2:30p Required Textbook Statistics for Experimenters: Design, Innovation, and Discovery, 2nd ed., by Box, Hunter, and Hunter We will use the book extensively, but it will be on reserve at Wendt Library if you do not wish to purchase it. Discussion Sections Disc 311: M 12:05 - 12:55p, in 2307 Chemsitry Disc 312: M 1:20 - 2:10p, in 1327 Sterling Discussion will be a chance to review lecture material, work through examples, and ask questions. Discussions will NOT meet the rst week of class. The rst discussions will be on September 9th. Computing We will be using R for most if not all of the analyses. R is a free, open-source, and extremely exible package, and is available for download online at: www.cran.r-project.org/. No prior experience is expected, but since comfort in R will be necessary for success in this course, there will be a tutorial of common R commands and conventions sometime in the rst few weeks of class. Homework There will be 7-9 homework assignments throughout the semester. Generally, assignments will be posted to Learn on Thursdays, and due to your TAs mailbox by 10:45a the following Thursday. No late work will be accepted for credit, but you get to drop your lowest score. I must ask that you do not collaborate on the homework. Exams There will be two midterm exams, likely at night, tentatively scheduled for the weeks of October 15th and November 26th. There will be no nal exam.

Final Project Instead of a nal exam, there will be a nal project. The project will ask you to: 1. Design an experiment of your choosing with at least 16 runs and at least 4 factors. 2. Perform the experiment to gather the data. 3. Analyze the data appropriately. 4. Write a report explaining your methods and presenting and interpreting your results. I will post some sample projects so you can see what people have done in the past. More details on the project will come later in the semester.

Grading Homework 25%; Each Midterm Exam, 20%; Final Project, 35%.

Tentative Syllabus (with text chapters)

1. Comparing Two Means : Unpaired and paired t-tests, blocking and randomization (Ch. 3) 2. Comparing Many Means : Fully randomized ANOVA, tting and evaluating, multiple comparisons (Ch. 4) 3. Complete Block Designs : Randomized complete blocks (Ch. 4) 4. Incomplete Blocks : Balanced incomplete block designs (Ch. 4) 5. Factorial Designs at Two Levels : Replicated and unreplicated, estimating main eects and interactions, tting and evaluating (Ch. 5) 6. Blocking Factorial Designs : Orthogonal blocks and confounding (Ch. 5) 7. Fractional Factorial Designs : Confounding relations (Ch. 6) 8. Factorial Designs at More Than Two Levels : General multi-way ANOVA (Ch. 8) 9. Time Permitting...: Latin Square Designs, Response Surface Methodology, Linear Regression (Chs. 4, 11)