CHEMOTHERAPY DRUGS

GENERIC/ DOSAGE/ CLASSIFICATION INDICATION TRADE FREQUENCY NAME Vincristine 1 gram/ml Antineoplastic For acute Sulfate 1.9 ml TIV leukemia (Oncovin) CONTRAINDICATIONS SIDE EFFECTS NURSING RESPONSIBILITIES Monitor blood pressure. Evaluate neurologic status. Know that neurotoxicity is a doselimiting adverse reaction. Monitor CBC with platelet count. Watch for signs and symptoms of blood dyscrasias. Stay alert for signs and symptoms of infection.

Hypersensitivity to drug Intrathecal use Demyelinating form of CharcotMarie-Tooth disease

Peripheral neuropathy Paresthesia Sensory loss Acute uric acid nephropathy Loss of deeptendon reflexes Hypertension Hypotension Nausea Vomiting Constipation Paralytic ileus Myelosuppressio n Leukopenia Gait changes Jaw pain Aspermia Amenorrhea

DOSAGE/ FREQUEN CY Cyclophosphamide 18.75 in (Cytoxan) 250 cc PNSS

GENERIC/ TRADE NAME

CLASSIFICA TION Antineoplastic

INDICATION Hodgkins disease, malignant lymphoma, multiple myeloma, leukemia, advanced mycosis fungoides, neuroblastoma, ovarian cancer, breast cancer, and certain other tumors

CONTRAINDICATI ONS Hypersensiti vity to drug Severe bone marrow depression

SIDE EFFECTS

NURSING RESPONSIBILITIES Assess infusion site for signs of extravasation Monitor hematologic profile to determine degree of hematopoietic suppression. Be aware that leucopenia is an expected drug effect and is used to help determine dosage. Monitor urine regularly for RBCs, which may precede hemorrhagic cystitis.

Nausea Vomiting Loss Of Appetite Or Weight Abdominal Pain Diarrhea Hair Loss Sores On The Mouth Or Tongue Changes In Skin Color Changes In Color Or Growth Of Finger Or Toe Nails

GENERIC/ TRADE NAME Actinomycin-D (Cosmegen)

DOSAGE/ FREQUENCY 0.56 ml in 250cc PNSS

CLASSIFICATION Antineoplastic

INDICATION Wilms' tumor, rhabdomyosarco ma, germ cell tumors, gestational trophoblastic disease, Ewing's sarcoma, testicular cancer, melanoma, choriocarcinoma , neuroblastoma, retinoblastoma, uterine sarcomas, and soft tissue sarcoma.

CONTRAINDICATIONS -

SIDE EFFECTS Hypersensitivity - Low blood count. to any - Hair loss component of this (occurs within product. weeks) It should not be given at or about - Nausea and vomiting the time of (occurs within infection with hours to days) chickenpox or herpes zoster - Mouth sores (occurs within because of the weeks) risk of severe - Diarrhea generalized (occurs within disease which days to weeks) may result in - Skin death. problems (follicular acne, redness, desquammatio n - peeling of skin) - Sensitivity to sunlight.

NURSING RESPONSIBILITIES - Advise patient to avoid exposure to people with infections. Warn patient that alopecia may occur but is usually reversible. Tell patient to report sore throat, fever, or signs of bleeding promptly.