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FOR IMMEDIATE RELEASE, AUGUST 27 2009 FORWARD INQUIRIES TO: Prof. Chris Frampton Chief Scientific Officer

FOR IMMEDIATE RELEASE, AUGUST 27 2009

FORWARD INQUIRIES TO:

Prof. Chris Frampton Chief Scientific Officer SAFC Pharma Pharmorphix Solid State Services + 44 1223 225383

MEDIA INQUIRIES:

Mark Button Impress Public Relations + 1 503 616 3817 mark@impress-pr.com

SAFC PHARMA® PREMIERES GLOBAL SYMPOSIUM ON ADVANCES IN ORGANIC SOLID STATE CHEMISTRY

St. Louis, MO - August 27, 2009 - SAFC® (www.safcglobal.com), a member of the Sigma- Aldrich® Group (NASDAQ: SIAL), announced today that its SAFC Pharma® business segment will host its first Pharmorphix® Organic Solid State Chemistry Symposium at The Trinity Centre, Cambridge Science Park, UK, from 9:00 a.m. to 4:00 p.m. on September 25, 2009.

Solid-form characterization and research can play an important part in enhancing the understanding of the physical properties of active pharmaceutical ingredients (APIs) and enable important modifications to ensure patient benefit, optimize product development and protect intellectual property.

The complimentary symposium will foster a collaborative forum, with discussions led by industrial and academic global experts in this rapidly expanding field of solid state chemistry, including H. Lundbeck A/S, Pfizer, AstraZeneca, the University of Bradford’s Institute of Pharmaceutical Innovation and SAFC Pharma. With its objective being the exchange of ideas, the symposium will include papers and presentations on current and recently-completed projects.

Following the presentations, delegates will have the opportunity to attend a networking reception and a tour of SAFC Pharma’s state-of-the-art 12,500 sq. ft. Pharmorphix solid state research facility.

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reception and a tour of SAFC Pharma’s state-of-the-art 12,500 sq. ft. Pharmorphix solid state research facility.

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Page 2 SAFC Pharma’s Chief Scientific Officer for Phar morphix Solid State Services, Professor Chris Frampton,

SAFC Pharma’s Chief Scientific Officer for Pharmorphix Solid State Services, Professor Chris Frampton, commented: “We are delighted that such distinguished members of the solid state community have donated their time to this premiere industry event. Solid state chemistry is a rapidly evolving field, as the testing, analysis and optimization of APIs play an increasingly critical role in drug development.”

Delegates are asked to register in advance at www.safcpharma.com/ss-symposium. Talks to be covered during the symposium include:

"Enantiomers, Racemates and Resolutions: examples from Citalopram: Part 1" - Dr. Heidi Lopez de Diego, H. Lundbeck A/S

"Enantiomers, Racemates and Resolutions: examples from Citalopram: Part 2" - Dr. Robert Dancer, H. Lundbeck A/S

"Crystallization from a Molecular Perspective" - Dr. Nick Blagden, Institute of Pharmaceutical Innovation, University of Bradford

"Pharmaceutical Crystallization Processes and their Impact on Particle Properties" - Dr. Gerry Steele - Process Engineering, Process Research and Development, AstraZeneca R&D

"Characterizing Pharmaceutical Solids using Light Microscopy and Scanning Electron Microscopy" - Dr. Gary Nichols, Pfizer Central Research

"Structural Considerations for Cocrystallization" - Prof. Chris Frampton, SAFC Pharma - Pharmorphix Solid State Services

SAFC Pharma’s Pharmorphix Solid State Research technology is well-recognized for its solid form research studies and is used by pharmaceutical customers around the globe to enhance their development programs.

About SAFC: SAFC® is the custom manufacturing and services group within Sigma-Aldrich that focuses on high-purity inorganics for high technology applications, cell culture products and services for biopharmaceutical manufacturing, biochemical production and the manufacturing of complex, multi-step organic synthesis of APIs and key intermediates. SAFC has manufacturing facilities around the world dedicated to providing manufacturing services for companies requiring a reliable partner to produce their custom manufactured materials. SAFC has four focus areas – SAFC Pharma®, SAFC Supply Solutions®, SAFC Biosciences®, and SAFC Hitech® – and had annual sales of over $600 million in 2008. SAFC is one of the world’s 10 largest fine chemical businesses. For more information about SAFC, visit www.safcglobal.com.

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of the world’s 10 largest fine chemical businesses. Fo r more information about SAFC, visit www.safcglobal.com.

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Page 3 About SAFC Pharma®: SAFC Pharma is a complete pipeline partner fo r the development

About SAFC Pharma®: SAFC Pharma is a complete pipeline partner for the development and cGMP custom manufacturing of complex small-molecule APIs and biologic drug products. It combines world-class project management and chemistry support for all stages of the drug discovery and development process from research and discovery, through pre-clinical and clinical development to commercialization, with a focus on reducing the drug development time-line. SAFC has the widest range of raw materials, highly qualified and experienced staff, state-of-the-art facilities and an integrated portfolio of services, including full analytical and regulatory support and is a leader in emerging technologies, including high-potency APIs, solid-state chemistry, viral products and chemical-biologic API conjugates. For more information visit www.safcpharma.com.

About Sigma-Aldrich: Sigma-Aldrich is a leading Life Science and High Technology company. Its biochemical and organic chemical products and kits are used in scientific research, including genomic and proteomic research, biotechnology, pharmaceutical development and as key components in pharmaceutical, diagnostic and other high technology manufacturing. The Company has customers in life science companies, university and government institutions, hospitals, and in industry. Over one million scientists and technologists use its products. Sigma-Aldrich operates in 38 countries and has 7,800 employees providing excellent service worldwide. Sigma-Aldrich is committed to Accelerating Customer Success through Innovation and Leadership in Life Science, High Technology and Service. For more information about Sigma-Aldrich, please visit its award-winning Web site at http://www.sigma-aldrich.com.

SAFC®, SAFC Biosciences®, SAFC Supply Solutions®, SAFC Pharma®, SAFC Hitech®, Pharmorphix® and Sigma-Aldrich® are registered trademarks of Sigma-Aldrich Biotechnology L.P. and Sigma-Aldrich Co.

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and Sigma-Aldrich® are registered trademarks of Sigma-Aldrich Bi otechnology L.P. and Sigma-Aldrich Co. # # #