Code: 9A23701

1
BIOINFORMATICS
(Biotechnology) Max. Marks: 70 Answer any FIVE questions All questions carry equal marks *****

B.Tech IV Year I Semester (R09) Regular & Supplementary Examinations December/January 2013/14

Time: 3 hours

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What is http? Write an essay on role of web servers in bioinformatics. What is the evidence for evolution? Write about homology by Alfred Russel Wallance. Enumerate the steps involved in Sanger DNA sequencing. Write an essay on substitution matrices. Differentiate PAM and BLOSUM. Explain about molecular modeling databases (MMDB). Discuss the importance of NCBI, EMBL and DDBJ. Write an essay on secondary databases. Explain about any two enzyme databases.

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Code: 9A23701

2
BIOINFORMATICS
(Biotechnology) Max. Marks: 70 Answer any FIVE questions All questions carry equal marks *****

B.Tech IV Year I Semester (R09) Regular & Supplementary Examinations December/January 2013/14

Time: 3 hours

1 2

Give a note on elementary commands and protocols in bioinformatics. Differentiate homologous and orthologus. Explain morphological and phylogenetic homology with mention to Willie Henning. Give a brief note on next generation sequencing. Describe the Whole-Genome Shotgun sequencing. Write a short note on: (a) Needleman-Wunsch algorithm (b) Smith-Waterman algorithm Discuss the importance of NCBI, EMBL and DDBJ. Explain about protein information resources. Describe the organization and management of KEGG drug databank. List out the tools used for phylogenetic analysis and explain.

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Code: 9A23701

3
BIOINFORMATICS
(Biotechnology) Max. Marks: 70 Answer any FIVE questions All questions carry equal marks *****

B.Tech IV Year I Semester (R09) Regular & Supplementary Examinations December/January 2013/14

Time: 3 hours

Write a short note on: (a) FTP (b) TELNET Discuss molecular homology according to Richard Owen. Explain the sequence alignment/map in bioinformatics. Give an account on global and local alignments with an example. Elaborate on protein data bank. List out the other protein structure databases. Explain the organization and importance of KEGG. Write an account on EXPASY proteomic tools. What is multiple sequence alignment? Explain their methods.

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Code: 9A23701

4
BIOINFORMATICS
(Biotechnology) Max. Marks: 70 Answer any FIVE questions All questions carry equal marks *****

B.Tech IV Year I Semester (R09) Regular & Supplementary Examinations December/January 2013/14

Time: 3 hours

1 2 3 4 5 6 7 8

Explain the major research areas in bioinformatics. Describe the homology and genetics based on Charles Darwin. What is a Genome? Explain about genome mapping. Explain the methods used for pairwise sequence alignment. Write an account on classification of biodatabases. Enumerate the advantages of Swissprot database. Explain the organization and management of metabolic reconstruction database. Define the following: (a) Cladogram (b) Dendogram (c) Phylogram (d) Chronogram

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