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* About BMJ <http://resources.bmj.com/bmj/about-bmj> * Explore the BMJ <http://resources.bmj.com/bmj/about-bmj/explore-bmj-microsites> Home </> > Comment </channels/comment.dtl> > BMJ 2001;323(7321):1136 (10 November), doi:10.1136/bmj.323.7321.1136 -----------------------------------------------------------------------/BMJ/ 2001;323:1136 ( 10 November ) Reviews /Press/ Cannabis the *wonder* drug? At a secret location in the home counties of England, 15 000 cannabis plants are being grown quite legally. They are being^ bred from strains whose names---Hindu Kush, Skunk, Northern Lights,^ Gloria---are redolent of the Amsterdam coffee house scene. Their^ psychoactive seed heads, which stand over two metres high, are^ carefully studied---but never smoked. For these plants are being^ cultivated as part of the world's first commercial trial of medicinal^ cannabis. The company behind the trial, GW Pharmaceuticals, based at Porton Down Science Park in Wiltshire, has had a rather good fortnight.^ Firstly, the home secretary, David Blunkett, announced on 23 October^ that the government would liberalise the law concerning possession^ and use of cannabis. He also indicated that he would be ready^ to license cannabis for medicinal use to treat multiple sclerosis^ and other conditions as soon as research trials were completed.^ Most commentators (including, albeit grudgingly, the /Daily Mail/^ leader writers) seemed to approve. On 24 October shares in GW^ Pharmaceuticals jumped from 13p to^ 108p. Secondly, the press this week hailed cannabis as a *wonder* drug and a miracle cure. Under the headline "Cannabis proves a medical^ miracle," the /Observer/, a newspaper not normally known for its^ hype, reported on 4 November that the first clinical trials of^ cannabis were showing that it was "capable of transforming the^ lives of very sick^ people." After decades of cannabis being condemned as one of the scourges of Western society, this all seemed a bit too good to be^ true. Were these claims going too far? What sort of evidence was^ available? The source of the /Observer/'s story was the BBC 1 /Panorama/ documentary "Cannabis from the chemist," broadcast on 4 November.^ The programme looked at two separate trials---a pilot study (n=23)^ in East Anglia of the effects of cannabis on the pain caused by^ nerve damage, and the early stages of a much larger trial in Oxford^ of the effects of cannabis on people with multiple sclerosis.^ The programme did not make clear the total number involved in^ the latter trial---its medical director said in passing that he^ had initially seen 20 patients---and based its conclusions on the^ experiences of Sandra, Tyrone, and Jo (n=3). GW Pharmaceuticals is the only company in the United Kingdom that has been given a licence to grow cannabis for medicinal^ use. /Panorama/'s journalists were the only ones to have access^ to those taking part in

the company's trials. Alex, who had a^ spinal injury, and Sandra, Tyrone, and Jo, who all had multiple^ sclerosis, received daily doses of cannabis sprayed under the^ tongue. They all showed remarkable progress. Although none of^ them had expected to be cured, they all experienced relief from^ pain. Jo, the 58 year old wife of a school chaplain, had struggled^ to lift her legs before the trial but afterwards was able to lift^ them 25 times. She hailed the drug's effects as "miraculous,"^ and her husband said, "It's not a word that either of us would^ use^ lightly." Dr Willy Notcutt of the East Anglian pilot study said, "The results so far have exceeded what I dared hope for . . . we are^ seeing 80% of our patients getting good quality benefit from the^ cannabis." Some were getting almost total pain relief, he said.^ "We have seen their pain scores go down to zero." </cgi/content/full/323/7321/1136/Fu1> *View larger version* (126K): [in this window] </cgi/content/full/323/7321/1136/Fu1> [in a new window] </cgi/content-nw/full/323/7321/1136/Fu1> */Panorama /*reporter Steve Bradshaw amid legally grown cannabis More dramatic claims were made by Professor Lester Grinspoon of Harvard Medical School, one of the world's leading proponents^ of medicinal cannabis. Although not involved in the trials, Grinspoon^ claimed that cannabis would "eventually be used by millions of^ people around the planet." Just as penicillin "was considered^ the *wonder* drug of the 1940s," he said, cannabis "will eventually^ be seen as the *wonder* drug of the 21st^ century." On /Panorama/'s website (www.bbc.co.uk/panorama <http://www.bbc.co.uk/panorama>) the next day, Philip Robson, medical director of the Oxford trials, expressed^ concern about newspaper "*wonder* drug" headlines. He said: "We^ have to keep this in perspective. This seems to be a medicine^ which is incredibly useful for people who haven't had very much^ luck with the standard medicines, and that is really good, but^ I think to talk about *wonder* drugs and miracle cures is way over^ the^ top." But newspaper headline writers can hardly be blamed for their "*wonder* drug" approach to the story. /Panorama /had given them^ plenty to go on, concluding: "We could see the drug in the chemist^ in just two years." Admittedly, Grinspoon's wild optimism was^ balanced with words of caution from, among others, Susan Greenfield,^ professor of pharmacology at Oxford University, who said: "The^ very term *wonder* drug is very frightening." And it would have^ been odd if /Panorama/ had not embraced the opportunity to follow^ this historic experiment. But the result was rather like a commercial^ for GW Pharmaceuticals, even though the company's name was never^ mentioned. Footnotes tjackson@bmj.com <mailto:tjackson@bmj.com> *Trevor Jackson*. /BMJ/ -----------------------------------------------------------------------* BMJ 2001* </misc/terms.shtml>

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