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PSYC 3102: Intro to Behavioral Genetics (Carey !"am 2 Multiple Choice #he $%r$ose o& lin'a(e analyses is to: a )etermine the e"act location o& a (ene * )etermine the a$$ro"imate location o& a mar'er c )etermine the a$$ro"imate location o& a (ene ) )etermine the e"act location o& a mar'er e none o& the a*ove +n ,-.P is: a a ,e$etitive -amily .in'e) Polymor$hism * a ,i*osomal -at .i$oProtein c a ,ecom*ination -re/%ency .in'a(e Pro*e ) a ,estriction -ra(ment .en(th Polymor$hism e a ,e$etitive -re/%ently .in'e) Primer + 'aryoty$e is: a an o*serva*le $henoty$e * an o*serva*le (enoty$e c monosomy o& a chromosome ) a $ict%re o& staine) chromosomes e trisomy o& a chromosome Do0n1s syn)rome is characteri2e) *y: a +l2heimer1s3li'e $atholo(y * a*normal &in(er$rints an) $alm$rints c $rotr%)in( mo%th ) increase) le%'emia ris' e all o& the a*ove + DCG is: a a Disease 0ith CG re$eats * a Disor)er 0ith Chromosomal Ga$s c a Disor)er 0ith Com$le" Genetics ) a Disease that is Com$letely Genetic e none o& the a*ove + ma4or loc%s &or a )isor)er: a )etermines 0hether or not a $erson 0ill (et the )isor)er * ca%ses a $henoco$y _____

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c is a mar'er %se) in lin'a(e analyses ) is a 5en)eli2in( &orm o& the )isor)er e has a relatively lar(e e&&ect on the )isor)er In)ivi)%als 0ith 6illiam1s syn)rome ten) to: a have an el&ish a$$earance * have im$aire) non3ver*al a*ilities c have normal ver*al a*ilities ) have m%sical a*ility e none o& the a*ove 5en)el1s la0 o& se(re(ation states that: a some here)itary &actors )ominate others * each $arent $asses 1 o& 2 here)itary &actors at ran)om to o&&s$rin( c lin'e) loci are transmitte) as a %nit ) here)itary &actors &or one trait are transmitte) in)e$en)ent o& those &or another trait e all o& the a*ove Pra)er36illi syn)rome: a is ca%se) *y the same chromosomal a*normality that ca%ses +n(elman1s Syn)rome * is ca%se) *y inheritance o& a micro)eletion &rom the &ather c is characteri2e) *y o*esity )%e to overeatin( ) is )%e to (enomic im$rintin( e all o& the a*ove + $ro*e: a carries a li(ht *%l* * *in)s 0ith its com$lementary se/%ence c is sin(le3stran)e) ) i)enti&ies a match *et0een the $ro*e an) ,N+ (or DN+ e all o& the a*ove + #%rner1s Syn)rome in)ivi)%al has the 'aryoty$e: a 789YY * 7:9; c 7<99 ) 7899Y e 7:Y; 6hich o& the &ollo0in( is N;# a ty$e o& $olymor$hism= a ,-.P * SNP c varia*le n%m*er o& tan)em re$eats ) insertion e none o& the a*ove _____

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Genetic lin'a(e 0as &irst )escri*e) *y: a 5en)el * 5or(an c Galton ) 6atson e Cric' True/False -amilial +D is associate) 0ith early onset> + man 0ith (enoty$e +; at the +B; loc%s has the *loo) ty$e ($henoty$e +> 99Y males are hy$ermasc%lini2e) an) a((ressive> Pra)er36illi an) +n(elman1s Syn)romes res%lt &rom )eletions o& the same chromosomal se(ment> #he *est $re)ictor o& Do0n1s syn)rome is $aternal a(e> #he &re/%ency o& chromosomal )isor)ers at &ertili2ation is a*o%t 10? 100? o& +D cases are acco%nte) &or *y +PP@ $resenilin 1@ $resenelin 2@ an) +$o!7> +n e"tra or missin( a%tosome is %s%ally o'>

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Fill in the Blank #he techni/%e ____________________ is %se) to am$li&y DN+> I& t0o loci are rarely se$arate) *y recom*ination@ then they are ____________________> #he A(ol) stan)ar)B &or )ia(nosin( +D is i)enti&ication ____________________ an) ____________________> #he 'aryoty$e ____________________ characteri2es a normal male> ____________________ is the ma4or )isa)vanta(e o& $o$%lation3*ase) association st%)ies> ____________________ is the $ro(ressive an) irreversi*le loss o& intellect%al &%nction> #he $rocess o& ma'in( )o%*le3stran)e) DN+ sin(le3stran)e) is calle) ____________________>

CCC I have remove) the ShortD.on( +ns0er $ortion@ in case Dr> Carey )eci)es to %se the same /%estions@ *%t here are the *asics o& those /%estions: Eno0 ho0 to (ive the (enoty$es@ $henoty$es@ an) &re/%encies &or a (iven cross ('no0 ho0 to )o a P%nnett s/%are an) (ive res%lts 6hat is the meanin( o& 1$1:>33= Eno0 0hat PC,@ ,-.P@ an) SNP stan) &or an) 0hat they are an) 0hat their si(ni&icance is Eno0: +l2heimer1s )iseaseF restriction en2ymes an) &%nctionF electro$horesisF an) $olymor$hisms